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Associations between fatty acid consumption and vascular health: evidence from the Caerphilly cohort

Published online by Cambridge University Press:  19 October 2012

K. M. Livingstone ,
J. A. Lovegrove  and
D. I. Givens
K. M. Livingstone
Affiliation:
Food Production and Quality Research Division, Faculty of Life Sciences, University of Reading, RG6 6AR
J. A. Lovegrove
Affiliation:
Department of Food and Nutritional Sciences and Institute for Cardiovascular and Metabolic Research, Faculty of Life Sciences, University of Reading, RG6 6AR, UK
D. I. Givens
Affiliation:
Food Production and Quality Research Division, Faculty of Life Sciences, University of Reading, RG6 6AR
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Abstract

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Information
Proceedings of the Nutrition Society , Volume 71 , Issue OCE2: Summer Meeting hosted by the Irish Section, 16–19 July 2012, Translational nutrition: integrating research, practice and policy , 2012 , E47
Copyright
Copyright © The Authors 2012

Although research has indicated that the replacement of dietary saturated fatty acids (SFA) with mono- or poly-unsaturated fatty acids (MUFA or PUFA) may reduce the risk of cardiovascular disease (CVD) via effects on lipids, blood pressure and endothelial function( Reference Vafeiadou, Weech and Sharma 1 – Reference Hooper, Summerbell and Thompson 2 ), evidence from long-term prospective studies on the effect of fatty acid consumption on vascular health is insufficient and inconsistent( Reference Siri-Tarino, Sun and Hu 3 ).

The present analysis aimed to investigate the relationship between total fat, SFA, PUFA and an estimated MUFA intake (eMUFA) with systolic and diastolic blood pressure (SBP and DBP), pulse wave velocity (PWV), plasma insulin, glucose, triacylglycerol (TAG) and fibrinogen concentrations using data from the Caerphilly cohort. Included in this cohort were 2,512 men, aged 45–59 years at phase (P) 2, who were followed up at 5 year intervals (P 2–3 for total fat, P 2–3 for SFA, eMUFA and PUFA and P 1–2 for insulin, P 1–3 and 5 for SBP, DBP, TAG, glucose and fibrinogen and P 5 for PWV). Multiple linear regression analysis was used to investigate cross-sectional and longitudinal relationships, with adjustments for dietary and lifestyle variables.

PWV, pulse wave velocity; SBP; systolic blood pressure; DBP, diastolic blood pressure; 1, association between dietary intake at P 2 with blood pressure at P 2; 2, association between dietary intake at P 2 with PWV at P 5; coefficients were significantly different at

* P<0.05,

** P<0.01,

*** P<0.001.

At P 2, increasing SFA consumption was associated with higher P 2 SBP (P=0.043), DBP (P=0.002) and glucose concentrations (P=0.001) and higher PWV in P V (P=0.049). Also at P 2, increasing PUFA consumption was associated with a lower P 2 SBP (P=0.022) and P 5 PWV (P=0.009). This led to a lower P 2 SBP (P=0.017), DBP (P=0.016), glucose (P=0.025) and P 5 PWV (P=0.006) with an increasing dietary P:S (PUFA:SFA) ratio. The present results suggest that consumption of SFA is associated with CVD risk, while PUFA may be related to cardio-protective markers. Importantly, as indicated by PWV, consumption of SFA and PUFA may predict future risk of CVD.

This work was supported by the Barham Benevolent Trust and the University of Reading. The authors gratefully acknowledge the Department of Social Medicine in Bristol for access to the Caerphilly archive and valuable support from Professor Peter Elwood and Janet Pickering.

References

1. Vafeiadou, K, Weech, M, Sharma, V et al. (2012) Brit J Nutr 107, 303–24.CrossRefGoogle Scholar
2. Hooper, L, Summerbell, CD, Thompson, RL et al. (2011) Proc Nutr Soc 70, E222.CrossRefGoogle Scholar
3. Siri-Tarino, PW, Sun, Q, Hu, FB et al. (2010) Am J Clin Nutr 91, 535–46.CrossRefGoogle Scholar
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