Malaria remains one of the indelible hallmarks of the postcolonial world. It is also a trope through which various communities identify themselves. Today, malaria continues to dominate agendas of the World Health Organization, multinational philanthropy, research in tropical medicine, electoral politics, medical journalism and governance. In recent decades, novelists have appropriated malaria as a central problematic of anti-realist fictionFootnote ¹ or have mentioned the presence of anti-malarial drugs in the traveller's kit as an indicator of persisting western psychoses about erstwhile British colonies.Footnote ² Malaria is also considered to be a signifier of the limits of postcolonial modernity, development and democracy. This is most evident in contemporary India, where reports have described malaria as an endemic agent, shaping the encounters between Maoist insurgents and state-endorsed paramilitary forces in the interiors.Footnote ³

In recent years, malaria has been acknowledged to be a globally relevant disease, which shaped the patterns of a variety of world historical processes: human settlements in Ancient Rome, the European colonisation of the ‘New World’, the demography of agrarian England, nationalist reconstructions and ethnic conflicts in the twentieth century, and the Cold War. Many historians have engaged with contemporary medical science to explain malarial outbreaks in the wider non-European world in the nineteenth and twentieth centuries in terms of social inequalities, racial degenerations, poverty, hunger, water stagnation and ill-conceived and carelessly implemented government projects.Footnote ⁴ Twentieth-century (or even more recent) scientific understandings of malaria have been invoked to diagnose mortalities and to analyse events in earlier centuries.Footnote ⁵ Other kinds of scholarship have situated efforts to eradicate malaria within the social histories of newly consolidated nation-states, as well as global geopolitics.Footnote ⁶

Rather than taking scientific medicine as an explanatory frame, this book aims to explain the processes through which scientific medical knowledge about malaria itself was put together. It extends the premise that medical or scientific knowledge has been a product of contingent historical processes.Footnote ⁷ To understand the widespread significance of malaria in the contemporary world, many recent books have examined the history of malaria in the twentieth century.Footnote ⁸ Instead, I focus on the long nineteenth century, and explore the intellectual, cultural and political histories of the ways in which the category was reconsolidated and sustained as an object of natural knowledge and social control. The nineteenth century deserves more scholarly attention, in its own right, as a significant phase in the history of malaria, rather than being treated as a period characterised by flawed archaic understandings about the disease, which would be rectified eventually in course of the next century.Footnote ⁹ Embarking on this project, I soon realised that malaria was perceived as amongst the most active and commodious disease-causing entities during much of the century. It was associated with a variety of debilities far beyond fevers, ranging from idiocy to impotence. Malaria was not a self-contained category. Rather, malaria was co-constituted with political discourses and practices relating to a network of plants, events, places, drugs and insects. Nor were narratives about malaria confined within nationally bounded geographies or the territorial units reified by area studies. British India, the focus of this book, was an integral part of an interconnected world in which malaria, cinchona plants, the drug quinine (extracted from cinchona barks) and subsequently mosquitoes were co-constituted.

In exploring the makings and persistence of malaria as an enduring diagnostic category, I have drawn upon particular strands within constructivist histories of science and medicine, and historical epistemology, more generally.Footnote ¹⁰ Invoking the vocabulary common to these overlapping genres of scholarship, this book analyses how malaria, cinchonas, quinine and mosquitoes were co-produced, maintained and repaired as prepackaged, self-evident, ready-made and black-boxed categories in British India.Footnote ¹¹ But such an analysis needs to be combined with a historiography that has exposed the overlapping trajectories of modernity and empire.Footnote ¹² Indeed, the entrenchment of integrated regimes of modernity and empire since the late eighteenth century necessitated the proliferation of categories of rule and knowledge. Such categories have over time appeared legitimate, commonsense, credible, foundational and even universal across the expanses of the colonial world and beyond. The stories explaining the making and naturalisation of these categories, it has been suggested, might reveal ‘the ambivalences, the contradictions, the use of force, and the tragedies and the ironies’ that have attended the histories of modern empires.Footnote ¹³ An eclectic range of such categories, from the economicFootnote ¹⁴ to the primitives,Footnote ¹⁵ or indeed population,Footnote ¹⁶ were historically produced or remade in a variety of conjunctures engendered by modern empires and their legacies both within Europe and its colonies. Like many of these categories and processes, the circulation of words like malaria, quinine and cinchona was augmented in post-Enlightenment Europe and Victorian and Edwardian England. In the course of the nineteenth century, these were reconfigured as natural, inevitable and relevant in distant corners of the British Empire. The predicaments of the wider colonial world in turn reshaped and sustained them, while also redefining the ways in which these were understood in Europe itself.

Malaria established itself as a recurrent category amongst government officials in British India and other parts of the colonial world by the third quarter of the century. Its status as a valid and credible category was seldom in doubt within the bureaucracy even as its meanings and physical characteristics were upheld as imprecise, fluid and contentious. Various commentators considered malaria simultaneously as familiar and enchanting, hackneyed and enigmatic, quotidian and dreadful.Footnote ¹⁷ Despite or perhaps because of this, malaria continued to be imagined as the most flexible, elusive and yet ubiquitous disease-causing entity through much of the century. The effects of malaria were reported to have been encountered in diverse and disparate geographical terrains across the colonial world and beyond: from inhospitable military trenches to long-distance sea voyages, from monotonous plains to eventful frontiers, from sun-baked deserts to impenetrable ravines and jungles. Both as a material and a metaphor, it was invoked consistently in narratives about travels and settlements. Malaria found itself entangled with the diagnoses of an exhaustive range of everyday and spectacular illnesses; the management of individual and collective bodies; the prejudices of smell, colour and class; efforts to make sense of lands, landscapes and objects; and debates about agricultural improvement, land revenue as well as urban and sanitary governance. A few decades later in 1923 when Rabindranath Tagore, by then a Nobel laureate and later apotheosised as the national poet of India, called for a ‘war with malaria’, the category had already acquired newer connotations, often in consonance with shifting patterns in late-imperial politics.Footnote ¹⁸ At the same time, it continued to occupy the centre stage in vernacular imagination as a crucial node of anti-colonial resistance and nationalist reconstruction, percolating into the arena of provincial print cultures.

In situating the different understandings and practices relating to malaria within various layers of imperial history, this book provides an occasion for extending the conversations between the histories of science and medicine on the one hand and scholarship on empire and postcolonial studies on the other. It speaks to the concerns opened up by an interrelated field of scholarship, which over the past two decades has been described variously as histories of colonial medicine, histories of science and empire, global and postcolonial histories of science.Footnote ¹⁹ These multi-sited histories have revised in many ways the received imperial and nationalist geographies of scientific and medical knowledge formation.Footnote ²⁰ Apart from exposing patterns of connections and correspondence between colonies held by various European imperial states, these histories have discarded narcissistic and Eurocentric narratives of triumphalism, progress and unilateral diffusion of scientific knowledge from Europe to the rest of the world. The increasing emphasis on a variety of non-European actors and sources have not only added multiple accents to the histories of early-modern and modern sciences but have also diversified our insights into their textures, vocabularies and dictions.Footnote ²¹ Themes such as translation, exchange, circulation, racism and violence have now emerged as crucial in understanding the making of modern science and medicine.

Despite methodological admonishments implicit in these works, various existing histories have continued to focus exclusively on colonial administrative policies, and have often tended to reify at face value the official categories of scientific and medical governance. Similarly, single-minded emphases on vernacular processes of translation and cultural difference have not done enough to question the façade of an originally unbiased domain of colonial-state-endorsed metropolitan scientific knowledge. There has been a growing awareness of the need then to go beyond scholarly models that either internalise the epistemological foundations of the colonial state or continue to romanticise an autonomous, exotic and incommensurable indigenous sphere.Footnote ²² The case of malaria inspires historians to contest long-held distinctions between an objective as well as sacrosanct world where knowledge is produced and a messy outside world where knowledge is consumed, resisted and displaced.Footnote ²³ Thus here I return to the mainstream category of public health and to factories, laboratories, plantations and government files to interrogate the surviving myths of stability and autonomy prevalent about some of the most celebrated and apparently insulated sites of modern science and medicine.

Rather than focusing only on official policy makers, I propose to locate (wherever feasible) the European, colonial and vernacular sources in a single analytic fieldFootnote ²⁴ to examine not only predictable differences, but also revealing overlaps between them. As the story of how the histories of cinchonas, malaria, quinine and eventually mosquitoes and the intimacies between them were shaped unfolds, in the following chapters, it will be clear that the concerns of a range of institutions, groups and individuals were enmeshed. I explore the interplay between a variety of sources: bureaucratic records relating to the medical and sanitary departments of the colonial state; correspondence involving the office of the Secretary of State for India; private papers of London-based drug-manufacturing families; annual reports of dispersed cinchona plantations and quinine factories; widely circulating medical journals and military manuals; Bengali vernacular literature and advertisements; and reports and memoirs written by peripatetic physicians, phyto-chemists, geographical explorers, entomologists, botanists, geologists and chemical examiners within British India and beyond. Bengal, from where most of my non-English examples are drawn, was home to one of the earliest cinchona plantations and quinine factories to have been established in the colonial world, even as it continued being recounted in various sources as amongst the more intensely malarial provinces of the British Empire. Witness to one of the most enduring encounters with colonial rule in modern history, Bengal provides various examples not only of how practices and knowledge relating to malaria were circulated, translated, appropriated and contested across linguistic contexts, but also of the ways in which colonial modernity, medical conceptions about the body and provincial print markets interacted to shape vernacular public culture.

Malarial Subjects covers the period 1820 to 1909: from the discovery of quinine in Paris to the organisation of the Imperial Malaria Conference in the British Indian summer capital at Simla. As I have hinted already, this period witnessed gradual shifts in the ways malaria was perceived: from being an elusive and generic cause of many diseases to its reconfiguration as the name of a mosquito-borne parasitic fever disease; from being an essential theme in asserting colonial difference and governance to emerging as an agenda in nationalist reconstruction and development. Over this period, various plants including eucalyptus, sunflower and opiumFootnote ²⁵ were attributed with properties to cure diseases associated with malaria. However, despite changes in the epistemological and political meanings of malaria, quinine (extracted from cinchona barks) continued to figure throughout the period, as its most enduring and quintessential remedy. These two categories were projected as invariably connected.

The structure of this book reflects how, during the period of around ninety years covered here, the figure of quinine informed understandings about the disease/disease-causing entity it was supposed to remedy. Taken together, Chapters 1 and 2 show that the establishment of cinchona plantations in colonial Dutch Java, French Algeria and British India in the 1850s coincided with considerable redefinition of malaria as a colonial disease. Besides, while the word malaria was certainly not absent in sources available in English in the eighteenth century, an unprecedented circulation of the category across the British Empire followed the discovery of quinine in 1820. John MacCulloch's treatise published in 1827, seven years after quinine was discovered, was widely recognised as the first book-length English work on malaria. Moreover, while examining the making of Burdwan fever, an epidemic attributed to malaria in the Bengal presidency in British India in the 1860s and 1870s, Chapter 3 indicates that quinine often functioned as a quick-fix diagnostic agent to determine the malarial identity of enigmatic maladies. A patient could be retrospectively diagnosed as malarial if s/he had recuperated after consuming quinine. Chapter 4 argues that quinine itself was not a homogenous, stable or inflexible entity. But rather, as hinted in the final chapter, quinine was adaptive instead to the shifts within imperial rule and to the changing meanings of malaria. The Imperial Malaria Conference of 1909, an important event towards the end of the period covered by the book, was organised in Simla in the wider context in which the therapeutic properties attributed to quinine were questioned, and reasserted in the wake of significant readjustments in the aetiology of malaria.

Malarial Subjects therefore questions the predictable teleological sequences of scientific knowledge production, which various histories of colonial science and medicine often take for granted. In such a schema, problems inevitably precede the solutions they tend to necessitate; an answer is possible only after a question has been posed; cures are responses to well-defined maladies, which have already revealed themselves. This book, in contrast, presents an overlapping history of quinine and malaria to expose various ways in which cures and their diseases, solutions and their problems could sustain and shape one another.Footnote ²⁶

At the same time, each chapter focuses on individual scientific and medical categories to examine how British imperial rule in India reconsolidated or engendered them: a plant (cinchonas), a diagnostic category (malaria), an epidemic (Burdwan fever) and a drug (quinine). The final chapter reveals the imperial networks through which the histories of a group of insects (mosquitoes) and malaria were entangled in the 1900s, and how these entanglements in turn affected the social and political meanings of quinine. This book joins existing efforts to critique colonial rule by exposing how certain aspects of the ‘taken for granted intellectual framework’ of British colonialism were consolidated.Footnote ²⁷ Such an exercise also enables me to extend the prevailing insights into the links between Empire and the production of natural knowledge.Footnote ²⁸ Indeed, the production of social and scientific perceptions about the constellation of natural artifacts explored here, as well as the establishment of interrelationships between them were enabled considerably by various kinds of connections held together by the British Empire. This history reconfirms how Empire occasioned not only the imbrications of the apparently unconnected worlds of colonial governance, vernacular cultures, medical knowledge and pharmaceutical commerce, but also structured the ways in which British India was linked to events, sites and processes in South America, Dutch Java, Ceylon, Burma, Mauritius, German and British Africa, and Trinidad.

The arrival of cinchonas to be planted in British India in the late 1850s coincided with the end of the Sepoy mutiny, and the transfer of the political authority to govern significant parts of the subcontinent from the East India Company to the British Crown. This book ends around 1909; the year when the first Imperial Malaria Conference was organised as well as the Morley Minto Reforms were enacted, a few years before the onset of the World War I. The decades in between witnessed a particular phase of imperial rule, which was marked by an unprecedented convergence of regimes of knowledge, biopolitics and political economy in British India.Footnote ²⁹ This was reflected in the interconnected network of conversations about agricultural improvement, class, colours, credibility, diseases, distance, drugs, expertise, factories, field-works, governance, insects, labour recruitments, laboratories, legitimacies, markets, places, plants, plantations, purities and races about to be explored in this book. This phase, which Stoler and Cooper have described as the ‘embourgeoisement of imperialism’, was also characterised by the emergence of a newer commitment to govern the moralities, productivities and individual conducts of imperial subjects on either side of the colonial divide.Footnote ³⁰ Unsurprisingly, these concerns fed into ensuing conceptions about colonial bodies, health, diseases and their cures. During these decades, exigencies and apparatuses of Empire reshaped not only the meanings and contours of individual categories, such as cinchonas, quinine, malaria and mosquitoes, but also engendered the terms of intimate interactions between them.

However, imperial constructs such as cinchonas, quinine, malarial objects or mosquitoes were enabling artifacts rather than passive, inert or vacuous (non)entities. The predominant anthropocentrism in conventional political histories of empire has begun to be contested by historians who have commented variously on the multiple careers of animals, materials and plants in British imperial history.Footnote ³¹ I build upon and extend further the possibilities inherent in these works to argue that Empire itself was reconsolidated while shaping the histories of nonhumans such as cinchona plants, objects considered as malarial, the drug quinine, mosquitoes and even parasites. Therefore, the word nonhumans used in this book does not refer to animals alone. But rather, it explores the symbiotic dynamics between the British Empire, on the one hand, and a spectrum of other-than-humans (including materials and organisms), on the other.

The British Empire was clearly not a monolithic, unchanging, omnipotent agent or a ‘totalising efficacy’.Footnote ³² Rather than homogenizing it as a coherent point of origin or a preordained institutional framework, or a distant overarching entity, Empire can be interpreted more incisively as a constellation of processes, which was coming into being along with the script that it was putting together.Footnote ³³ There has been an increasing awareness of the ways in which the dominant themes in mainstream political and cultural history – capital, democracy, enlightenment, the everyday, modernity, romanticism – did not only engender but were in turn permeated and delimited by nonhumans such as animals, oil, automata, technology, metals, machines and alike.Footnote ³⁴ Similarly, I uncover how imperial artifacts such as cinchonas, malarial objects, quinine and mosquitoes, in turn, deepened the structural, ideological, prejudicial, biopolitical, as well as physical foundations of Empire itself. Nonhuman objects and organisms (like cinchonas, quinine, mosquitoes, malarial objects), medical knowledge about them and Empire were not only entangled, but to quote Donna Haraway, were also ‘becoming with’ one another.Footnote ³⁵ The history of malaria therefore provides an occasion to probe the constitutive intersections amongst the nineteenth-century worlds of medicine, nonhumans and empire.

Recent histories on a diverse range of topics have shown renewed interest in undertaking the bold challenge to narrate the materiality of nonhuman objects and organisms by transgressing the conventional confines of discourse analysis and the history of ideas.Footnote ³⁶ In the process, significant histories of medicine and the environment have drawn upon the sciences almost immediately.Footnote ³⁷ There is a need to go beyond descriptions of straightforward materiality or uncontaminated nonhuman agency often revealed in scientifically informed histories. Therefore I am inspired by Timothy Mitchell's pioneering first chapter in Rule of Experts, which evokes the figure of mosquitoes in mid-twentieth-century Egyptian history, to interrogate straightforward notions of agency prevalent in social theory. Yet, Mitchell does not open up for analysis the contingent histories of medical entomology through which mosquitoes were labeled as vectors of malaria earlier in the century.Footnote ³⁸ In this book I explore ways to trace the inscriptions of materials and objects while examining the links between the production of scientific knowledge and Empire.Footnote ³⁹ Therefore I examine the empowering properties acquired by cinchona plants, malarial objects, mosquitoes and different forms of quinine, while social perceptions and scientific knowledge about them was being produced by imperial assemblages and associations.Footnote ⁴⁰ These categories and entities under construction were not passive, impotent, inflexible, unresponsive or insignificant. I analyse the extent to which these, whether as categories undergoing constitution or as deployed metaphors, or as objects of knowledge, governance and production were, as Bruno Latour suggests, ‘modifying a state of affairs by making a difference’.Footnote ⁴¹ Quinine, mosquitoes, cinchonas and other nonhumans could make variously their presence felt while being constituted by discourses and practices enabled by Empire. Thus it might be simplistic to conceive of them as willful, full-fledged, autonomous, preordained and straightforward actors wholly independent of the political circumstances they found themselves in.

Therefore, this book reasserts the need for political histories of British Empire to be more attentive to the lessons of science studies, an interdisciplinary field that takes the agency and existence of nonhuman objects and creatures as a central point of inquiry.Footnote ⁴² Science studies scholars have suggested that the imbrication of nonhumans in various actions can be shown to be both simultaneously constructed and real.Footnote ⁴³ They have undertaken the challenge to narrate the capabilities of nonhuman objects and organisms while resisting the temptations of scientific reductionism and biological determinism. In their theoretically more ambitious moments, science studies scholars have contested essentialist and straightforward notions of agency itself. They have argued that agency (and even existence) should be considered the exclusive monopoly of neither autonomous humans nor nonhumans. Instead, they point out that these are properties of collectives or assemblages of humans and nonhumans, subjects and objects.Footnote ⁴⁴

While drawing upon some of these insights, this book also hopes to demonstrate how scholarship about empire might, in turn, situate these lessons of science studies within enduring historical contexts, by revealing the ways in which nonhumans (or indeed collectives of humans and nonhumans) were implicated within histories of violence, expansion and intercultural exchange. Attention to the history of British Empire in South Asia will uncover not just how cinchonas, malarial objects, quinine and mosquitoes were reshaped in the long nineteenth century. Focus on colonial South Asia will further show that these plants, materials and insects did not constitute a self-sufficient and autonomous world of nonhumans. But rather, specific socio-material assemblages that proliferated in the British imperial context sustained them. I also suggest that imperial biopolitics in British India were founded on the simultaneous processes of anthropomorphism, animalisation and dehumanisation, which, on occasions, blurred the distinctions between humans and nonhumans/subjects and objects.Footnote ⁴⁵ Attribution of lifelike properties (if not human characteristics) to cinchonas, quinine, malarial objects and mosquitoes converged with and stoked exclusionary narratives about race, place, colour, purity, primitives, class and labour.

The title of this book Malarial Subjects simultaneously draws on different uses of the word subjects. In a public lecture delivered in London in March 1882, the British Indian bureaucrat Joseph Fayrer deployed the expression ‘malarial subjects’ to refer to patients suffering from ‘various symptoms of the malarial poison’ ranging from remittent fever to ‘a variety of indefinite complaints’.Footnote ⁴⁶ Going beyond the overt medical connotation of the original expression, the title of this book signals at the imperial context in which the lecture was delivered. Malaria had emerged by then as an extensively deployed trope to describe colonial lands, landscapes and people. Besides, Fayrer's status as an authority on malaria was connected to his long career as a bureaucrat in British India. His examples of native people, who figured in his narrative as either vulnerable to or immune from malaria, were drawn from various parts of the colonial world including Algeria, Burma, India, Guinea or the West Indies.Footnote ⁴⁷ Malarial Subjects therefore indicates that various medical and colonial identities were bound by nineteenth-century histories of the category malaria. The title of the book also acknowledges that malaria attracted the attention of a variety of intellectual persuasions. The medical history of malaria was shaped by contributions from geologists, geographers, meteorologists, chemists, economic-botanists, engineers, natural historians and entomologists. In a more methodological sense malaria provides opportunity for deeper conversation between the apparently disparate historiographies of empire, medicine and nonhumans. Finally, the history of malaria can also provide the occasion to complicate the received distinctions between the subject and the object. In history writing, the word subject is variously understood to mean the subjugated, or an acting agent, or a product of relationships of power. I ask in this book if these different conceptualisations of the subject can be extended to incorporate the nonhuman. In the process, I also urge that the binary of human and nonhuman itself needs to be historicised.