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S100A7 in the Fallopian tube: a comparative study

Published online by Cambridge University Press:  23 October 2013

Juan M Teijeiro  and
Patricia E. Marini
Juan M Teijeiro
Affiliation:
Área Biología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 590, Rosario S2002LRK, Argentina.
Patricia E. Marini*
Affiliation:
Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 590, Rosario S2002LRK, Argentina. Instituto de Biología Molecular y Celular de Rosario, IBR-CONICET, Rosario, Argentina.
*
All correspondence to Patricia E. Marini. Área Biología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 590, Rosario S2002LRK, Argentina. Tel: +54 341 4350661. Fax: +54 341 4804601. e-mail: marini@ibr.gov.ar or pmarini@fbioyf.unr.edu.ar
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Summary

The oviduct is a dynamic organ in which final gamete maturation, fertilization and early embryo development take place. It is considered to be a sterile site; however the mechanism for sterility maintenance is still unknown. S100A7 is an anti-microbial peptide that has been reported in human reproductive tissues such as prostate, testicle, ovary, normal cervical epithelium and sperm. The current work reports the presence of S100A7 in the Fallopian tube and its localization at the apical surface of epithelial cells. For comparison, porcine S100A7 was used for antibody development and search for peptide in reproductive tissues. Although present in boar seminal vesicles and seminal plasma, S100A7 was not detected on female porcine organs. Also, in contrast with the human protein, porcine S100A7 did not show anti-microbial activity under the conditions tested. Phylogenetic analyses showed high divergence of porcine S100A7 from human, primate, bovine, ovine and equine sequences, being the murine sequence at a most distant branch. The differences in sequence homology, Escherichia coli-cidal activity, detectable presence and localization of S100A7 from human and pig, suggest that there are possible different functions in each organism.

Keywords

Fallopian tubeOviduct spermS100A7Seminal plasma
Type
Research Article
Information
Zygote , Volume 23 , Issue 2 , April 2015 , pp. 229 - 236
Copyright
Copyright © Cambridge University Press 2013 

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