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Real-time image and time-lapse technology to select the single blastocyst to transfer in assisted reproductive cycles

Published online by Cambridge University Press:  11 April 2023

Romualdo Sciorio Open the ORCID record for Romualdo Sciorio [Opens in a new window] ,
Gerard Campos ,
Simone Palini ,
Domenico Baldini  and
Ronny Janssens
Romualdo Sciorio*
Affiliation:
Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, Scotland, EH16 4SA, UK
Gerard Campos
Affiliation:
Girexx Fertility Clinics, 17004, Girona, Spain
Simone Palini
Affiliation:
Physiopathology of Reproduction Unit, Cervesi Hospital, Via Ludwig Van Beethoven 1, Cattolica, Italy
Domenico Baldini
Affiliation:
IVF Center MomòFertilife Clinic, Bisceglie, Italy
Ronny Janssens
Affiliation:
BE-ART IVF, Kloosterstraat 76, 2880 Bornem, Belgium
*
Author for correspondence: Romualdo Sciorio. Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, Scotland, EH16 4SA, UK. E-mail: sciorioromualdo@hotmail.com
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Abstract

The success of an assisted reproduction cycle should be the achievement of a healthy singleton live birth following the replacement of one embryo. Therefore, one of the most critical points for embryologists has been the selection criteria and how to choose the best embryo to transfer with high implantation potential. In this vein, morphological evaluation has been historically the method applied. However, this practice relies on a limited number of single observations and is associated with high operator variability. Recently, a major innovation in embryo culture has been the introduction of a new type of incubator with integrated time-lapse monitoring, which enables the embryologist to analyze the dynamic events of embryo development, from fertilization to blastocyst formation. This novel practice is quickly growing and has been implemented in many IVF clinics worldwide. Therefore, the main aim of this review is to illustrate the benefits of time-lapse technology in a modern embryology laboratory. In particular, we discuss the blastocyst collapse(s) event and morphometric blastocyst assessment and analyse their association with embryo viability and implantation potential.

Keywords

Blastocyst collapseEmbryo cultureMorphometric blastocyst assessmentPregnancy outcomeSingle-blastocyst transferTime-lapse technology
Type
Review Article
Information
Zygote , Volume 31 , Issue 3 , June 2023 , pp. 207 - 216
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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