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Impact of the number of retrieved oocytes on IVF outcomes: oocyte maturation, fertilization, embryo quality and implantation rate

Published online by Cambridge University Press:  19 December 2022

M. Jamil Open the ORCID record for M. Jamil [Opens in a new window] ,
H. Debbarh ,
A. Kabit ,
M. Ennaji ,
M. Zarqaoui ,
W. R. Senhaji ,
M. Hissane ,
B. Saadani ,
N. Louanjli  and
R. Cadi
M. Jamil*
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
H. Debbarh
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco
A. Kabit
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
M. Ennaji
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
M. Zarqaoui
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
W. R. Senhaji
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
M. Hissane
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
B. Saadani
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
N. Louanjli
Affiliation:
IVF Center IRIFIV, Iris Clinic, Casablanca, Morocco
R. Cadi
Affiliation:
Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco
*
Author for correspondence: M. Jamil. Laboratory of Molecular Genetic Physiopathology and Biotechnology. Department of Biology, Ain Chock Faculty of Sciences, HASSAN II University, Casablanca, Morocco. E-mail: malakjamil93@gmail.com
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Summary

The process of oocyte retrieval represents a key phase during the cycles of in vitro fertilization (IVF). It involves controlled ovarian stimulation to retrieve the highest number of oocytes possible. According to many previous studies, the higher the number of oocytes the higher the chances of obtaining embryos for multiple transfers. In this study, in total, 1987 patients were retrospectively reviewed to investigate the correlations between the number of retrieved oocytes and the subsequent IVF outcomes. Patients were divided into three groups according to the number of retrieved oocytes (Group 1: ≤5 oocytes; Group 2: 6–15 oocytes; Group 3: ≥15 oocytes). The results showed a significant negative correlation between oocyte number and maturation rate as well as fertilization rate. However, a significant positive correlation was found between oocyte number and the blastulation rate. The implantation rate after fresh embryo transfers was higher in group 2 (6–15 oocytes) compared with group 1 (≤5 oocytes). According to our findings, we conclude that oocyte numbers between 6 and 15 oocytes can result in the highest chances of positive IVF outcomes in terms of embryo quality and fresh embryo transfers with lower risks of ovarian hyperstimulation.

Keywords

BlastulationEmbryo qualityImplantationIn vitro fertilizationOocyte retrieval
Type
Research Article
Information
Zygote , Volume 31 , Issue 1 , February 2023 , pp. 91 - 96
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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