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Comparative study between SpermSlow™ hyaluronan and traditional sperm selection in ICSI outcome

Published online by Cambridge University Press:  23 January 2023

Ahmed Abd Elraouf ,
Sayed Bakry ,
Ahmed Kadry ,
Othman F. Abdelzaher  and
Mohammed Adel Open the ORCID record for Mohammed Adel [Opens in a new window]
Ahmed Abd Elraouf
Affiliation:
International Islamic Center for Population Studies and Research, Al-Azhar University, Darassa, Cairo, Egypt
Sayed Bakry
Affiliation:
Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Ahmed Kadry
Affiliation:
International Islamic Center for Population Studies and Research, Al-Azhar University, Darassa, Cairo, Egypt
Othman F. Abdelzaher
Affiliation:
Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Mohammed Adel*
Affiliation:
Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
*
Author for correspondence: Mohammed Adel. Laboratory of Embryology, Department of Zoology, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt. E-mail: dr.m.adel2016@gmail.com
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Summary

The role of hyaluronic acid (HA) as a ‘physiologic selector’ is also well recognized in vitro: it has been demonstrated that spermatozoa that bind to immobilized HA in vitro are those having completed their plasma membrane remodelling, and cytoplasmic and meiotic maturation. Sperm selection using HA has been expected to increase the implantation rate in intracytoplasmic sperm injection (ICSI) cycles. This work was designed to evaluate an alternative product for slowing sperm motility that contains HA and measures its outcomes: fertilization rate, embryo quality, and implantation and pregnancy rates. The present study found a positive drift in embryo quality that was statistically significant in the study group (SpermSlow™-ICSI) with teratozoospermia compared with PVP-ICSI in the same group. There were differences in the pregnancy rate (statistically insignificant in normozoospermia, asthenozoospermia, oligozoospermia, and teratozoospermia) in the SpermSlow-ICSI group compared with PVP-ICSI. The HA-ICSI technique in assisted reproduction technology (ART) is an important way to improve fertilization rate, embryo quality, and pregnancy rate.

Keywords

Embryo qualityHA-ICSIICSIMale infertilityPVP-ICSI
Type
Research Article
Information
Zygote , Volume 31 , Issue 2 , April 2023 , pp. 180 - 187
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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