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5-Alfa reductase type 2 (SRD5A2) gene rs523349 polymorphism is not associated with non-obstructive azoospermia in Turkish patients

Published online by Cambridge University Press:  14 October 2020

Munevver Serdarogullari Open the ORCID record for Munevver Serdarogullari [Opens in a new window] ,
Onder Coban Open the ORCID record for Onder Coban [Opens in a new window] ,
Zalihe Yarkiner ,
Seda Gulec Yilmaz ,
Tuba Akdeniz  and
Turgay Isbir
Munevver Serdarogullari*
Affiliation:
British Cyprus IVF Hospital, Embryology, Nicosia, Cyprus Cyprus International University, Faculty of Medicine, Northern Cyprus via Mersin 10, Turkey
Onder Coban
Affiliation:
British Cyprus IVF Hospital, Embryology, Nicosia, Cyprus
Zalihe Yarkiner
Affiliation:
Cyprus Science University, Software Engineering, Kyrenia, Cyprus
Seda Gulec Yilmaz
Affiliation:
Yeditepe University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
Tuba Akdeniz
Affiliation:
Yeditepe University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
Turgay Isbir
Affiliation:
Yeditepe University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey
*
Author for correspondence: Munevver Serdarogullari. British Cyprus IVF Hospital, Embryology, Nicosia, Cyprus. E-mail: munevver.coban@gmail.com
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Summary

Spermatogenesis is an androgen-dependent event, and testosterone is the major androgen source. The enzyme 5-alpha reductase converts testosterone to dihydrotestosterone (DHT) in testicular and peripheral tissues. Polymorphisms in genes encoding 5-alpha reductase may be associated with impaired male fertility. The present study aimed to investigate the relationship between 5-alpha reductase type 2 (SRD5A2) gene rs523349 polymorphism and non-obstructive azoospermia (NOA) in Turkish patients. The study included 75 NOA patients and 43 fertile men from Turkey. No significant relationship was found between SRD5A2 gene rs523349 polymorphism and male infertility (P = 0.071). There was a statistically significant difference in total testosterone level and total testis volume between NOA patients and the control groups, however there was no significant difference between serum follicle-stimulating hormone and luteinizing hormone levels. Our results showed that SRD5A2 gene rs523349 polymorphism was not associated with NOA in Turkish patients.

Keywords

5-Alfa reductase type 2AzoospermiaMale infertilityNon-obstructive azoospermia
Type
Research Article
Information
Zygote , Volume 29 , Issue 2 , April 2021 , pp. 118 - 121
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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