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Chicken anaemia virus: a short review

Published online by Cambridge University Press:  18 September 2007

A.L. Coombes
Affiliation:
PO Box 588, Biomedical Research Group, School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia
G.R. Crawford
Affiliation:
PO Box 588, Biomedical Research Group, School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia
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Abstract

Chicken anaemia virus (CAV) is a small, naked, icosahedral virus with an SS-DNA genome of 2.3 kb. The virus infects very young chicks (vertically by transovarial transmission) and causes anaemia, immunosuppression and skin lesions (CAV syndrome). The virus also infects older birds (by horizontal transmission) with no apparent signs of infection, although growth may be affected. In Australia the CAV syndrome is currently controlled by exposure of breeding stock to wild-type virus (no attenuated virus is available). The authors are currently investigating CAV-specified proteins and an attenuated virus vaccine and developing an ELISA for antibody detection with the Division of Animal Health, CSIRO.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1996

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References

Brentano, L., Mores, N., Wentz, I., Chandratilleke, D. and Schat, K.A. (1991) Isolation and identification of chicken infectious anaemia virus in Brazil. Avian Diseases 35: 793800CrossRefGoogle ScholarPubMed
Brewer, J., Saunders, J.M. and Chettle, N.J. (1994) The development of an enzyme linked immunosorbent assay to detect antibodies to chicken anaemia virus, and its comparison with the indirect immunofluorescence antibody test. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.408412.Google Scholar
Buchholz, U. and Von Bulow, V. (1994) Characterization of chicken anaemia virus (CAV) proteins. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp. 366375Google Scholar
Chandratilleke, D., O'Connell, P. and Schat, K.A. (1991) Characterisation of proteins of chicken infectious anaemia virus with monoclonal antibodies. Avian Diseases 35: 854862CrossRefGoogle ScholarPubMed
Chettle, N.J., Eddy, R.K., Saunders, J. and Wyeth, P.J. (1991) A comparison of serum neutralisation, immunofluorescence and immunoperoxidase tests for the detection of antibodies to chicken anaemia agent. Veterinary Record 128: 304306CrossRefGoogle ScholarPubMed
Claessens, J.A.J., Schrier, C.C., Mockett, A.P.A., Jagt, E.H.J. and Sandermeijer, P.J.A. (1991) Molecular cloning and sequence analysis of the genome of chicken anaemia agent. Journal of General Virology 72: 20032006CrossRefGoogle ScholarPubMed
Connor, T.J., McNeilly, F., Firth, G.A. and McNulty, M.S. (1991) Biological characterisation of Australian isolates of chicken anaemia agent. Australian Veterinary Journal 68: 199201CrossRefGoogle ScholarPubMed
Douglas, A.J., Phenix, K., Mawhinney, K.A., Todd, D., Mackie, D.P. and Curran, W.L. (1995) Identification of a 24 kDa protein expressed by chicken anaemia virus. Journal of General Virology 74: 15571562CrossRefGoogle Scholar
Dren, Cs. N., Koch, G., Kant, A., Verschueren, C.A.J., van der EB, A.J. and Noteborn, M.H.M. (1994) A hot start PCR for the laboratory diagnosis of CAV. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.413420Google Scholar
Engstrom, B.E., Fossum, O. and Luthman, M. (1988) Blue wing disease of chickens: experimental infection with a Swedish isolate of chicken anaemia agent and an avian reovirus. Avian Pathology 17: 3350CrossRefGoogle Scholar
Fadly, A.M.Motta, J.V., Witter, R.L. and Nordgren, R.M. (1994) Epidemiology of chicken anaemia virus in specific-pathogen-free chicken breeder flocks. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.447455Google Scholar
Goodwin, M.A. and Brown, J. (1992) Inability of so-called chicken anaemia agent (CAA) infections to be diagnosed by anaemia and haematopoietic organ atrophy alone. Avian Diseases 36: 353355CrossRefGoogle ScholarPubMed
Goodwin, M.A., Steffens, W.L., Davis, J.F., Brown, J., Latimer, K.S. and Dickson, T.G. (1991) Diagnoses of infections by the so-called chick anaemia agent: anaemia and direct transmission electron microscopic detection of virus. Avian Diseases 35: 869871CrossRefGoogle ScholarPubMed
Goodwin, M.A., Lamichhane, C.M., Brown, J., Smeltzer, M.A., Miller, S.L., Girschick, T., Synder, D.B. and Dickson, T.G. (1992) Relationship of the enzyme-linked immunosorbent assay to indirect immunofluorescent antibody test for the detection of so-called chicken anaemia agent antibodies in serum from broiler breeders. Avian Diseases 36: 512514CrossRefGoogle ScholarPubMed
Goodwin, M.A., Smeltzer, M.A., Brown, J., Girshik, T., McMurray, B.L. and McCarter, S. (1993) Effect of so-called chicken anaemia agent maternal antibody on chick serologic conversions to viruses in the field. Avian Diseases 37: 542545CrossRefGoogle ScholarPubMed
Goryo, M., Suwa, T., Matsumoto, S., Umemura, T. and Itakura, C. (1987) Serial propagation and purification of chicken anaemia agent in MDCC-MSBI cell line. Avian Pathology 16: 149163CrossRefGoogle Scholar
Jeurissen, S.H.M., Janse, M.E., Van Roozelaar, D.J., Koch, G. and de Boer, G.F. (1992) Susceptibility of thymocytes for infection by chicken anaemia virus is related to pre- and posthatching developments. Developmental Immunology 2: 123129CrossRefGoogle Scholar
Jorgensen, P.H., Otte, L., Nielsen, O.L. and Bisgaard, M. (1994) Investigations on the epidemiology and economical impact of chicken anaemia virus infection in Danish broilers and broiler breeders. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.438446Google Scholar
Kato, A., Fujino, M., Nakamura, T., Ishihama, A. and Otaki, Y. (1995) Gene organization of chicken anaemia virus. Virology 209: 480488CrossRefGoogle Scholar
Koch, G., Van. Roozelaar, D.J., Verschueren, C.A.J., van der EB, A.J. and Noteborn, M.H.M. (1994) The formation of neutralising epitopes of chicken anaemia virus requires the synthesis of its proteins VP1 and VP2 in the same cell. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.498506Google Scholar
Koch, G., Van. Roozelaar, D.J., Verschueren, C.A.J., van der EB, A.J. and Noteborn, M.H.M. (1995) Immunogenic and protective properties of chicken anaemia virus proteins expressed by baculovirus. Vaccine 13: 763770CrossRefGoogle ScholarPubMed
Lamichhane, C.M., Snyder, D.B., Girschick, T., Goodwin, M.A. and Miller, S.L. (1992) Development and comparison of serologic methods for diagnosing chicken anaemia virus infections. Avian Diseases 36: 725729CrossRefGoogle Scholar
McConnell, C.D.G., Adair, B.M. and McNulty, M.S. (1993) Effects of chicken anaemia virus on cell-mediated immune function in chickens exposed to the virus by a natural route. Avian Diseases 37: 366374CrossRefGoogle Scholar
McIlroy, S.G., McNulty, M.S., Bruce, D.W., Smyth, J.A., Goodall, E.A. and Alcorn, M.J. (1992) Economic effects of clinical chicken anaemia agent infection on profitable broiler production. Avian Diseases 36: 566574CrossRefGoogle ScholarPubMed
McNeilly, F., Allan, G.M., Muffett, D.A. and McNulty, M.S. (1991) Detection of chicken anaemia agent in chickens by immunofluorescence and immunoperoxidase staining. Avian Pathology 20: 125132CrossRefGoogle ScholarPubMed
McNulty, M.S. (1991) Chicken anaemia agent: a review. Avian Pathology 20: 187203CrossRefGoogle ScholarPubMed
McNulty, M.S., Connor, T.J., McNeilly, F. and Spackman, D. (1989) Chicken anaemia agent in the United States: isolation of the virus and detection of antibody in broiler breeder flocks. Avian Diseases 33: 691694CrossRefGoogle ScholarPubMed
McNulty, M.S., Connor, T.J., McNeilly, F., McLoughlin, M.F. and Kirkpatrick, K.S. (1990) Preliminary characterisation of isolates of chicken anaemia agent from the United Kingdom. Avian Pathology 19: 6773CrossRefGoogle ScholarPubMed
McNulty, M.S., McIlroy, S.G., Bruce, D.W. and Todd, D. (1991) Economic effects of subclinical chicken anaemia agent infection in broiler chickens. Avian Diseases 35: 263268CrossRefGoogle ScholarPubMed
Meehan, B.M., Todd, D., Creelan, J.L., Earle, J.A.P., Hoey, E.M. and McNulty, M.S. (1992) Characterisation of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments. Archives of Virology 124: 301319CrossRefGoogle ScholarPubMed
Michalski, W.P., O'Rourke, D. and Bagust, T.J. (1996) Chicken anaemia virus antibody ELISA: Problems with non-specific reactions. Avian Pathology 25: 245254CrossRefGoogle ScholarPubMed
Noteborn, M.H.M. and Koch, G. (1995) Chicken anaemia virus infection: molecular basis of pathogenicity. Avian Pathology 24: 1131CrossRefGoogle ScholarPubMed
Noteborn, M.H.M., de Boer, G.F., van Roozelaar, D.J., Karreman, C., Kranenburg, O., Vos, J.G. et al. (1991) Characterisation of cloned chicken anaemia virus DNA that contains all elements for the infectious replication cycle. Journal of Virology 65: 31313139CrossRefGoogle ScholarPubMed
Noteborn, M.H.M., Verschueren, C.A.J., van Roozelaar, D.J., Veldkamp, S., van der EB, A.J. and de Boer, G.F. (1992) Detection of chicken anaemia virus by DNA hybridisation and polymerase chain reaction. Avian Pathology 21: 107118CrossRefGoogle ScholarPubMed
Noteborn, M.H.M., Todd, D., Verschueren, C.A.J., de Gauw, H.W.F.M., Curran, W.L., Veldkamp, S. et al. (1994a) A single chicken anaemia virus protein induces apoptosis. Journal of Virology 68: 346351CrossRefGoogle ScholarPubMed
Noteborn, M.H.M., Koch, G. and van der EB, A.J. (1994b) The molecular biology chicken anaemia virus - an introduction. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.341348Google Scholar
O'Rourke, D., Michalski, W.P. and Bagust, T.J. (1994) Chicken anaemia virus antibody ELISA reactions: practical experiences and problems in high-security SPF poultry flocks. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.456464Google Scholar
Otaki, Y., Saito, K., Tajima, M. and Nomura, Y. (1992) Persistence of maternal antibodies to chicken anaemia agent and its effects on the susceptibility of young chickens. Avian Pathology 21: 147151CrossRefGoogle ScholarPubMed
Pallister, J., Fahey, K.J. and Sheppard, M. (1994) Cloning and sequencing of the chicken anaemia virus (CAV) ORF-3 gene, and the development of an ELISA for the detection of serum antibody to CAV. Veterinary Microbiology 39: 167178CrossRefGoogle ScholarPubMed
Phenix, K.V., Meehan, M., Todd, D. and McNulty, M.S. (1994) Transcriptional analysis and genome expression of chicken anaemia virus. Journal of General Virology 75: 905909CrossRefGoogle ScholarPubMed
Rodenberg, J., De Wannemaeker, C., Heeren, J., Colau, D., Thiry, G. and Nordgren, R. (1994) Comparison of MSBI isolation and polymerase chain reaction to determine the presence of CAV in avian biological products. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.421424Google Scholar
Rosenberger, J.K. and Cloud, S.S. (1989) The effects of age, route of exposure, and coinfection with infectious bursal disease virus on the pathogenicity and transmissibility of chicken anaemia agent (CAA). Avian Diseases 33: 753759CrossRefGoogle Scholar
Soine, C., Watson, S.K., Rybicki, E., Lucio, B., Nordgren, R.M., Parrish, C.R. and Schat, K.A. (1993) Determination of the detection limit of the polymerase chain reaction for chicken anaemia virus. Avian Diseases 37: 467476CrossRefGoogle Scholar
Steenhuisen, W., Jagt, H.J.M. and Schrier, C.C. (1994) The use of a live attenuated CAV vaccine in breeder flocks in the Netherlands: In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.482497Google Scholar
Studdert, M.J. (1993) Circoviridae: new viruses of pigs, parrots and chickens. Australian Veterinary Journal 70: 121CrossRefGoogle ScholarPubMed
Taniguchi, T., Yuasa, N., Maeda, M. and Horiuchi, T. (1982) Haematopathological changes in dead and moribund chicks induced by chicken anaemia agent. National Institute of Animal Health Q (Japan) 22: 6169Google Scholar
Taniguchi, T., Yuasa, N., Maeda, M. and Horiuchi, T. (1983) Chronological observation on haematopathological changes in chicks inoculated with chicken anaemia agent. National Institute of Animal Health Q (Japan) 23: 112Google Scholar
Tham, K.M. and Stanislawek, W.L. (1992) Detection of chicken anaemia DNA sequences by the polymerase chain reaction. Archives of Virology 127: 245255CrossRefGoogle ScholarPubMed
Todd, D., Mackie, D.P., Mawhinney, K.A., Connor, T.J., McNeilly, F. and McNulty, M.S. (1990) Development of an enzyme-linked immunosorbent assay to detect serum antibody to chicken anaemia agent. Avian Diseases 34: 359363CrossRefGoogle Scholar
Todd, D., Creelan, J.L. and McNulty, M.S. (1991) Dot blot hybridisation assay for Chicken Anaemia Agent using a cloned DNA probe. Journal of Clinical Microbiology 29: 933939CrossRefGoogle ScholarPubMed
Todd, D., Mawhinney, K.A. and McNulty, M.S. (1992) Detection and differentiation of chicken anaemia virus isolates by using the polymerase chain reaction. Journal of Clinical Microbiology 30: 16611666CrossRefGoogle ScholarPubMed
Todd, D., Douglas, A.J., Phenix, K.V., Curran, W.L., Mackie, D.P. and McNulty, M.S. (1994) Characterisation of chicken anaemia virus. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June 1994, pp.349363Google Scholar
Vielitz, D. and Voss, M. (1994) Experiences with a commercial CAV-vaccine. In: Proceedings, International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia (Ed. Kaleta, E.F.), Rauischholzhausen, Germany, 21–24 June, pp.465481Google Scholar
Yuasa, N. (1983) Propagation and infectivity titration of the Gifu-1 strain of chicken anaemia agent in a cell line (MDCC-MSB1) derived from Marek's disease lymphoma. National Institute of Animal Health Q (Japan) 23: 1320Google Scholar
Yuasa, N. and Imai, K. (1986) Pathogenicity and antigenicity of eleven isolates of chicken anaemia agent (CAA). Avian Pathology 15: 639645CrossRefGoogle ScholarPubMed
Yuasa, N., Taniguchi, T. and Yoshida, I. (1979) Isolation and some characteristics of an agent inducing anaemia in chicks. Avian Diseases 23: 366385CrossRefGoogle Scholar