All herbicides were incorporated either as pretransplanting or posttransplanting treatments. Herbicides used were: ethyl N,N–di–n–propylthiolcarbamate (EPTC), propyl N,N–di–n–propylthiolcarbamate (1607), ethyl N,N–ethyl–n–butylthiolcarbamate (2060), propyl N,N–ethyl–n–butylthiolcarbamate (2061), O–(2,4–dichlorophenyl) O–methyl isopropylphosphoramidothioate (DMPA), 2–chloro–4–diethylamino–6–ethylamino–s–triazine (trietazine), and the dimethyl ester of 2,3,5,6–tetrachloroterephthalic acid (DCPA). EPTC, 1607, 2060, and 2061 at 3 lb/A (repeated 3 times), posttransplanting, and DMPA at 20 lb/A, pretransplanting, gave control of the annual weeds present with the exception of annual morningglory, and had no effects on tobacco yield or value. Nicotine, nornicotine, total alkaloids, and reducing sugar content of the cured leaf were not adversely affected by the thiolcarbamates, DMPA, amiben, or DCPA at rates used. Smoke and taste tests of tobacco treated with EPTC, DMPA, amiben, and DCPA revealed no undesirable flavors.