Hostname: page-component-848d4c4894-2xdlg Total loading time: 0 Render date: 2024-06-22T14:50:10.207Z Has data issue: false hasContentIssue false
  • English
  • Français

Time-dependent differential effects of cobalt ions on rod- and cone-driven responses in the isolated frog retina

Published online by Cambridge University Press:  02 June 2009

Cun-Jian Dong ,
John S. McReynolds  and
Hao-Hua Qian
Cun-Jian Dong
Affiliation:
Department of Physiology, University of Michigan, Ann Arbor Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
John S. McReynolds
Affiliation:
Department of Physiology, University of Michigan, Ann Arbor
Hao-Hua Qian
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
Get access Rights & Permissions [Opens in a new window]

Abstract

The effects of cobalt ions on 502-nm rod- and 575-nm cone-driven components of the b-wave of the electroretinogram were studied in the isolated frog retina. Addition of 100–150 μM cobalt initially caused a suppression of rod-driven responses and an enhancement of cone-driven responses. In the continued presence of cobalt, however, the rod-driven responses gradually recovered and the cone-driven responses became suppressed. These concentrations of cobalt had no effect on the rod- and cone-driven mass receptor potentials which were isolated in the presence of 4 mM glutamate. At higher concentrations of cobalt (1 mM or greater), both rod- and cone-driven b-wave responses were eliminated and there was no recovery in the continued presence of cobalt. The results suggest that cobalt has markedly different, time-dependent effects on signal transmission from rods and cones to second-order cells.

Keywords

RetinaCobaltSynaptic transmissionFrogRodCone
Type
Research Articles
Information
Visual Neuroscience , Volume 4 , Issue 4 , April 1990 , pp. 359 - 365
Copyright
Copyright © Cambridge University Press 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Attwell, D., Wilson, M. & Wu, S.M. (1984). A quantitative analysis of interactions between photoreceptors in salamander (Ambystoma) retina. Journal of Physiology 352, 703–737.CrossRefGoogle ScholarPubMed
Cervetto, L. & Piccolino, M. (1974). Synaptic transmission between photoreceptors and horizontal cells in the turtle retina. Science 183, 417–419.CrossRefGoogle ScholarPubMed
Dacheux, R.F. & Miller, R.F. (1976). Photoreceptor-bipolar cell transmission in the perfused retina eyecup of the mudpuppy. Science 191, 963–964.CrossRefGoogle ScholarPubMed
Dodt, E. & Jessen, K.H. (1960). Depression of cone sensitivity during dark adaptation. Experientia 16, 205–206.CrossRefGoogle ScholarPubMed
Dong, C.J., Qian, H.H., McReynolds, J.S., Yang, X.L. & Liu, Y.M. (1988). Suppression of cone-driven responses by rods in the isolated frog retina. Visual Neuroscience 1, 331–338.CrossRefGoogle ScholarPubMed
Evans, J.A., Hood, D.C. & Holitzman, E. (1978). Differential effects of cobalt ions on rod and cone synaptic activity in the isolated frog retina. Vision Research 18, 145–151.CrossRefGoogle ScholarPubMed
Fox, D.A. & Sillman, A.J. (1979). Heavy metals affect rod, but not cone, photoreceptors. Science 206, 78–80.CrossRefGoogle Scholar
Frumkes, T.E. & Eysteinsson, T. (1987). Suppressive rod-cone interaction in distal vertebrate retina: intracellular records from Xenopus and Necturus. Journal of Neurophysiology 53, 1361–1382.CrossRefGoogle Scholar
Hood, D.C. (1972). Suppression of the frog's cone system in the dark. Vision Research 12, 889–907.CrossRefGoogle ScholarPubMed
Kaneko, A. & Shimazaki, H. (1975). Synaptic transmission from photoreceptors to bipolar and horizontal cells in the carp retina. Cold Spring Harbor Symposia on Quantitative Biology 40, 537–546.CrossRefGoogle Scholar
Liebman, P.A. (1972). Microspectrophotometry of photoreceptors. In Handbook of Sensory Physiology, Vol. 7, Part 1, ed. Dartnall, H.J.A., pp. 481–528. Berlin: Springer-Verlag.Google Scholar
Liebman, P.A. & Entine, G. (1968). Visual pigments of frog and tadpole (Rana pipiens). Vision Research 8, 761–775.CrossRefGoogle ScholarPubMed
Lipetz, L.E. & Macnichol, E.F. Jr., (1983). Visual pigments of two freshwater turtles. Biophysical Journal 41, 2/2, 26a.Google Scholar
Ohtsuka, T. (1985). Spectral sensitivities of seven morphological types of photoreceptors in the retina of the turtle (Geoclemys reevesii). Journal of Comparative Neurology 237, 145–154.CrossRefGoogle ScholarPubMed
Schwartz, E.A. (1986). Synaptic transmission in amphibian retinae during conditions unfavourable for calcium entry into presynaptic terminals. Journal of Physiology 376, 411–428.CrossRefGoogle ScholarPubMed
Schwartz, E.A. (1987). Depolarization without calcium can release γ-aminobutyric acid from a retinal neuron. Science 238, 350–355.CrossRefGoogle ScholarPubMed
Sieving, P.A., Frishman, L.J. & Steinberg, R.H. (1986). Scotopic threshold response of proximal retina in cat. Journal of Neurophysiology 56, 1049–1061.CrossRefGoogle ScholarPubMed
Sillman, A.J. (1973). Rapid dark adaptation in the frog rod. Vision Research 13, 393–402.CrossRefGoogle ScholarPubMed
Sillman, A.J. (1974). Rapid dark adaptation in the frog cone. Vision Research 14, 1021–1027.CrossRefGoogle ScholarPubMed
Sillman, A.J., Bolnick, D.A., Bosetti, J.B., Haynes, L.W. & Walter, A.E. (1984). The effect of lead on photoreceptor esponse amplitude-inflence of the light stimulus. Experimental Eye Research 39, 183–194.CrossRefGoogle Scholar
Sillman, A.J., Bolnick, D.A., Bosetti, J.B., Haynes, L.W. & Walter, A.E. (1986). The effect of lead on photoreceptor response amplitude–influence of removing external calcium and bleaching rhodopsin. Neurotoxicology 7, 1–8.Google ScholarPubMed
Weakly, J.N. (1973). The action of cobalt ions on neuromuscular transmission in the frog. Journal of Physiology 234, 597–612.CrossRefGoogle ScholarPubMed
Wakabayashi, K., Gieser, J. & Sieving, P.A. (1988). Aspartate separation of the scotopic threshold response (STR) from the photoreceptor a-wave of the cat and monkey ERG. Investigative Ophthalmology and Visual Science 29, 1615–1621.Google Scholar