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Rod bipolar cells in the retina of the capuchin monkey (Cebus apella): Characterization and distribution

Published online by Cambridge University Press:  27 August 2009

SORAIA VALÉRIA O.C. LAMEIRÃO ,
DANIA E. HAMASSAKI ,
ANDERSON R. RODRIGUES ,
SILENE MARIA A. DE LIMA ,
BARBARA L. FINLAY  and
LUIZ CARLOS L. SILVEIRA
SORAIA VALÉRIA O.C. LAMEIRÃO
Affiliation:
Departamento de Fisiologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil
DANIA E. HAMASSAKI
Affiliation:
Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, São Paulo, Brazil
ANDERSON R. RODRIGUES
Affiliation:
Departamento de Fisiologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil
SILENE MARIA A. DE LIMA
Affiliation:
Departamento de Fisiologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil
BARBARA L. FINLAY
Affiliation:
Department of Psychology, Cornell University, Ithaca, New York, U.S.A.
LUIZ CARLOS L. SILVEIRA*
Affiliation:
Departamento de Fisiologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil
*
*Address correspondence and reprint requests to: Dr. Luiz Carlos de Lima Silveira, Núcleo de Medicina Tropical, Universidade Federal do Pará, Av. Generalíssimo Deodoro 92 (Umarizal), 66075-110 Belém, Pará, Brazil. E-mail: luiz@ufpa.br
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Abstract

Rod bipolar cells in Cebus apella monkey retina were identified by an antibody against the alpha isoform of protein kinase C (PKCα), which has been shown to selectively identify rod bipolars in two other primates and various mammals. Vertical sections were used to confirm the identity of these cells by their characteristic morphology of dendrites and axons. Their topographic distribution was assessed in horizontal sections; counts taken along the dorsal, ventral, nasal, and temporal quadrants. The density of rod bipolar cells increased from 500 to 2900 cells/mm2 at 1 mm from the fovea to reach a peak of 10,000–12,000 cells/mm2 at 4 mm, approximately 5 deg of eccentricity, and then gradually decreased toward retinal periphery to values of 5000 cells/mm2 or less. Rod to rod bipolar density ratio remained between 10 and 20 across most of the retinal extension. The number of rod bipolar cells per retina was 6,360,000 ± 387,433 (mean ± s.d., n = 6). The anti-PKCα antibody has shown to be a good marker of rod bipolar cells of Cebus, and the cell distribution is similar to that described for other primates. In spite of the difference in the central retina, the density variation of rod bipolar cells in the Cebus and Macaca as well as the convergence from rod to rod bipolar cells are generally similar, suggesting that both retinae stabilize similar sensitivity (as measured by rod density) and convergence.

Keywords

Rod bipolar cellsCapuchin monkeyPrimatesPKCαImmunocytochemistry
Type
Research Articles
Information
Visual Neuroscience , Volume 26 , Issue 4 , July 2009 , pp. 389 - 396
Copyright
Copyright © Cambridge University Press 2009

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