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The monoclonal antibody H386F labels microglia in the retinal nerve fiber layer of several mammals

Published online by Cambridge University Press:  02 June 2009

Nina Tumosa  and
James R. Baker
Nina Tumosa
Affiliation:
School of Optometry, University of Missouri, St. Louis
James R. Baker
Affiliation:
School of Optometry, University of Missouri, St. Louis
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Abstract

The antibody H386F revealed microglia in the retinae of several species: owl monkey, slow loris, galago, ferret, raccoon, and tree shrew. The shape, size, and density of labeled microglia were identical to those labeled by OX-42 and OX-41, two antibodies specific for microglia, in both galago and owl monkey. The labeled microglia varied little in retinal location. There was remarkably little variability in density, shape, number, and size of the abeled microglia between species. All labeled microglia were evenly distributed across, but restricted to, the nerve liber layer. Possible reasons for this restriction in location are discussed.

Keywords

MicrogliaImmunohistochemistryRetinaPrimatesCarnivores
Type
Research Articles
Information
Visual Neuroscience , Volume 14 , Issue 4 , July 1997 , pp. 663 - 669
Copyright
Copyright © Cambridge University Press 1997

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