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Low-level processing deficits underlying poor contrast sensitivity for moving plaids in anisometropic amblyopia

Published online by Cambridge University Press:  12 November 2012

YONG TANG ,
LINYI CHEN ,
ZHONGJIAN LIU ,
CAIYUAN LIU  and
YIFENG ZHOU
YONG TANG
Affiliation:
CAS Key Laboratory of Brain Function and Diseases and School of Life Sciences, University of Science and Technology of China, Hefei, People’s Republic of China
LINYI CHEN
Affiliation:
Research and Treatment Center of Amblyopia and Strabismus, University of Science and Technology of China, Hefei, People’s Republic of China Mingren Ophthalmology Hospital, Hefei, People’s Republic of China
ZHONGJIAN LIU
Affiliation:
Research and Treatment Center of Amblyopia and Strabismus, University of Science and Technology of China, Hefei, People’s Republic of China
CAIYUAN LIU
Affiliation:
Research and Treatment Center of Amblyopia and Strabismus, University of Science and Technology of China, Hefei, People’s Republic of China
YIFENG ZHOU*
Affiliation:
CAS Key Laboratory of Brain Function and Diseases and School of Life Sciences, University of Science and Technology of China, Hefei, People’s Republic of China Research and Treatment Center of Amblyopia and Strabismus, University of Science and Technology of China, Hefei, People’s Republic of China State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing, People’s Republic of China
*
†Address correspondence and reprint requests to: Yifeng Zhou, CAS Key Laboratory of Brain Function and Diseases and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People’s Republic of China. E-mail: zhouy@ustc.edu.cn.
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Abstract

Many studies using random dot kinematograms have indicated a global motion processing deficit originated from extrastriate cortex, specifically middle temporal area (MT) and media superior temporal area (MST), in patients with amblyopia. However, the nature of this deficit remains unclear. To explore whether the ability of motion integration is impaired in amblyopia, contrast sensitivity for moving plaids and their corresponding component gratings were measured over a range of stimulus durations and spatial and temporal frequencies in 10 control subjects and 13 anisometropic amblyopes by using a motion direction discrimination task. The results indicated a significant loss of contrast sensitivity for moving plaids as well as for moving gratings at intermediate and high spatial frequencies in amblyopic eyes (AEs). Additionally, we found that the loss of contrast sensitivity for moving plaids was statistically equivalent to that for moving component gratings in AEs, that is, the former could be almost completely accounted for by the latter. These results suggest that the integration of motion information conveyed by component gratings of moving plaids may be intact in anisometropic amblyopia, and that the apparent deficits in contrast sensitivity for moving plaids in anisometropic amblyopia can be almost completely attributed to those for gratings, that is, low-level processing deficits.

Keywords

Pattern motionGlobal processingMotion integrationMiddle temporal area (MT)
Type
Review Articles
Information
Visual Neuroscience , Volume 29 , Issue 6 , November 2012 , pp. 315 - 323
Copyright
Copyright © Cambridge University Press 2012

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