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D2-dopamine receptor blockade impairs motion detection in goldfish

Published online by Cambridge University Press:  01 March 2000

CARLOS MORA-FERRER
Affiliation:
Institut für Zoologie III, J. Gutenberg-Universität, 55099 Mainz, Germany
VOLKER GANGLUFF
Affiliation:
Institut für Zoologie III, J. Gutenberg-Universität, 55099 Mainz, Germany

Abstract

Under photopic illumination conditions, motion detection in goldfish is dominated by the long-wavelength-sensitive cone type (L-cone), and under scotopic conditions motion it is determined by rods (Schaerer & Neumeyer, 1996). The switch from rod-dominated to cone-dominated motion detection occurs during light adaptation. It has been suggested that dopamine acts as a neuronal light-adaptative signal. It is known that dopamine affects wavelength discrimination through D1-dopamine receptors (Mora-Ferrer & Neumeyer, 1996), and the dorsal light reflex through D1- and D2-dopamine receptors (Lin & Yazulla, 1994a). The purpose of this study was to determine whether dopamine influenced movement detection by goldfish, and if so, which dopamine receptor was involved. The D2-dopamine receptor antagonist sulpiride reduced the animal's sensitivity to the moving stimulus, whereas SCH 23390, a D1-dopamine receptor antagonist, did not have any effect. The effect of sulpiride is discussed in relation to known sulpiride effects on retinal neurons and the retinal pigment epithelium.

Type
Research Article
Copyright
2000 Cambridge University Press

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