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Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

Published online by Cambridge University Press:  21 February 2012

Marian Beekman
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands. M.Beekman@lumc.nl
Bastiaan T. Heijmans
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands.
Nicholas G. Martin
Affiliation:
Queensland Institute for Medical Research, Brisbane, Australia.
John B. Whitfield
Affiliation:
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia.
Nancy L. Pedersen
Affiliation:
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden.
Ulf DeFaire
Affiliation:
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Harold Snieder
Affiliation:
Twin Research & Genetic Epidemiology Unit, St.Thomas' Hospital, London, United Kingdom; Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia,Augusta, United States of America.
Nico Lakenberg
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands.
Peter de Knijff
Affiliation:
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden,The Netherlands.
Rune R. Frants
Affiliation:
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden,The Netherlands.
Gert Jan B. van Ommen
Affiliation:
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden,The Netherlands.
Cornelis Kluft
Affiliation:
Department of Vascular and Connective Tissue Research,TNO Prevention and Health, Leiden,The Netherlands.
George P. Vogler
Affiliation:
Department of Biobehavioral Health, Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania, United States of America.
P. Eline Slagboom
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands.
Dorret I. Boomsma
Affiliation:
Department of Biological Psychology, Free University of Amsterdam,Amsterdam,The Netherlands.
Corresponding
E-mail address:

Abstract

Plasma levels of lipoprotein(a) — Lp(a) — are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

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Copyright © Cambridge University Press 2003
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Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels
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