Hostname: page-component-5c6d5d7d68-7tdvq Total loading time: 0 Render date: 2024-08-07T11:40:26.691Z Has data issue: false hasContentIssue false

Short-Course Diphenoxylate Hydrochloride for Treatment of Methadone Withdrawal Symptoms

Published online by Cambridge University Press:  29 January 2018

T. J. Ives
Affiliation:
Department of Family Medicine, Trailer 15, 269H, University of North Carolina, Chapel Hill, NC 27514
C. C. Stults
Affiliation:
Department of Family Medicine, Trailer 15, 269H, University of North Carolina, Chapel Hill, NC 27514

Summary

The authors conducted a preliminary trial of a 5-day course of diphenoxylate in the treatment of out-patients with methadone withdrawal symptoms. Diphenoxylate provided substantial relief from detoxification symptoms with no drug-associated adverse effects.

Type
Research Article
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anonymous (1982) Top 200 products ranked. Drug Store News, 4, 612 Google Scholar
Glatt, M. M., Lewis, D. M. & Wilson, D. T. (1979) An oral method of the withdrawal treatment of heroin dependence. British Journal of Addiction, 65, 237–43.Google Scholar
Goodman, A. L. (1968) Use of diphenoxylate hydrochloride in the withdrawal period of narcotic addiction. Southern Medical Journal, 61, 313–6.CrossRefGoogle ScholarPubMed
Kleber, H. D. (1977) Detoxification from methadone maintenance: The state of the art. International Journal of Addiction, 12, 807–20.Google Scholar
Kleinman, M. H. & Arnon, D. (1977) Use of diphenoxylate hydrochloride in the management of the minor withdrawal syndrome during methadone detoxification. British Journal of Addiction, 72, 167–9.Google Scholar
Martin, W. R., Jasinski, D. R., Haertzen, C. A. et al (1973) Methadone—A re-evaluation. Archives of General Psychiatry, 28, 286–95.CrossRefGoogle Scholar
Rubenstein, J. S. (1979) Deliberate abuse of diphenoxylate hydrochloride. Western Journal of Medicine, 131, 148–50.Google Scholar
Senay, E. C., Dorus, W., Thornton, W. et al (1977) Withdrawal from methadone maintenance. Archives of General Psychiatry, 34, 361–7.CrossRefGoogle ScholarPubMed
Tennant, F. S., Krantz, K. D. & Dobpin, E. I. (1977) Use of difenoximide for narcotic detoxification. American Journal of Drug and Alcohol Abuse. 4, 123–35.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.