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Neural Mechanisms of Negative Symptoms

Published online by Cambridge University Press:  06 August 2018

Nancy C. Andreasen
Nancy C. Andreasen*
Affiliation:
Department of Psychiatry, University of Iowa College of Medicine, Iowa, USA
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Extract

When Kraepelin originally defined and described dementia praecox, he assumed that it was due to some type of neural mechanism. He hypothesised that abnormalities could occur in a variety of brain regions, including the prefrontal, auditory, and language regions of the cortex. Many members of his department, including Alzheimer and Nissl, were actively involved in the search for the neuropathological lesions that would characterise schizophrenia. Although Kraepelin did not use the term ‘negative symptoms', he describes them comprehensively and states explicitly that he believes the symptoms of schizophrenia can be explained in terms of brain dysfunction:

“If it should be confirmed that the disease attacks by preference the frontal areas of the brain, the central convolutions and central lobes, this distribution would in a certain measure agree with our present views about the site of the psychic mechanisms which are principally injured by the disease. On various grounds, it is easy to believe that the frontal cortex, which is specially well developed in man, stands in closer relation to his higher intellectual abilities, and these are the faculties which in our patients invariably suffer profound loss in contrast to memory and acquired ability.” Kraepelin (1919, p. 219)

Type
Research Article
Information
The British Journal of Psychiatry , Volume 155 , Issue S7: Negative Symptoms in Schizophrenia , November 1989 , pp. 93 - 98
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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References

Andreasen, N.C. (1986) (ed.) Can Schizophrenia be Localized in the Brain? Washington DC: American Psychiatric Press.Google Scholar
Andreasen, N.C., Smith, M.R. & Jacoby, C.G. (1982) Ventricular enlargement in schizophrenia: definition and prevalence. American Journal of Psychiatry, 139, 292–296.Google Scholar
Andreasen, N.C., Nasrallah, H.A., Dunn, V., et al (1986) Structural abnormalities in the frontal system in schizophrenia: a magnetic resonance imaging study. Archives of General Psychiatry, 43, 136–144.Google Scholar
Andreasen, N.C., Ehrhardt, J.C., Yuh, W.T., et al (in press) Magnetic resonance imaging in schizophrenia: an update. In Schizophrenia: Scientific Progress (eds Schulz, S.C. & Tamminga, C.A.) pp. 207–215. New York: Oxford University Press.Google Scholar
Ariel, R.N., Notestine, R., Goldon, C.J., et al (1983) Regional cerebral blood flow in schizophrenia. Archives of General Psychiatry, 40, 258–263.CrossRefGoogle Scholar
Bannon, M.J. & Roth, R.H. (1983) Pharmacology of mesocortical dopamine neurons. Pharmacological Review, 35, 63–68.Google Scholar
Berman, K.F., Zec, R.F. & Wwinberger, D.R. (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: II. Role of neuroleptic treatment, attention and mental effort. Archives of General Psychiatry, 43, 126–135.CrossRefGoogle ScholarPubMed
Berrios, G.E. (1985) Positive and negative symptoms and Jackson: a conceptual history. Archives of General Psychiatry, 42, 95–97.CrossRefGoogle Scholar
Buchsbaum, M.S. & Haier, R.J. (1987) Functional and anatomical brain imaging: impact on schizophrenia research. Schizophrenia Bulletin, 13, 15–132.Google Scholar
Buchsbaum, M.S., Ingvar, D.H., Kessler, R., et al (1982) Cerebral glucography with positron tomography. Archives of General Psychiatry, 39, 251–259.Google Scholar
Buchsbaum, M.S., DeLisi, L.E., Holcomb, H.H., et al (1985) Anterior-posterior gradients in cerebral glucose use in schizophrenia and affective disorder. Archives of General Psychiatry, 136, 722–723.Google Scholar
Creese, I., Burt, D.R. & Snyder, S.H. (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of antipsychotic drugs. Science, 198, 481–483.CrossRefGoogle Scholar
Crow, T.J. (1980) Molecular pathology of schizophrenia: more than one disease process? British Journal of Medicine, 280, 66–68.Google Scholar
Early, T.S., Reiman, E.M., Raichle, M.E., et al (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proceedings of the National Academy of Science, 84, 561–563.Google Scholar
Farde, L., Wiesel, F.A., Hall, H., et al (1987) No D2 receptor increase in PET study of schizophrenia. Archives of General Psychiatry, 44, 671–672.CrossRefGoogle ScholarPubMed
Fuster, J. (1980) The Prefrontal Cortex. New York: Raven Press.Google Scholar
Goldman-Rakic, P. (1984) The frontal lobes: uncharted provinces of the brain. Trends in Neuroscience (special issue) 7, No. 11.CrossRefGoogle Scholar
Gur, R.E., Gur, R.C., Skolnick, B.E., et al (1985) Brain function in psychiatric disorders: III. Regional cerebral blood flow in unmedicated schizophrenics. Archives of General Psychiatry, 42, 329–334.Google Scholar
Gur, R.E., Resnick, S.M., Alavi, A., et al (1987) Brain function in psychiatric disorders: I. A positron emission tomography study. Archives of General Psychiatry, 44, 119–125.CrossRefGoogle Scholar
Hughlings-Jackson, J. (1931) Selected Writings (ed. Taylor, J.). London: Hodder & Stoughton.Google Scholar
Ingvar, D.H. & Franzen, G. (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatrica Scandinavica, 15 425–462.Google Scholar
Jaskiw, G.E., Andreasen, N.C. & Weinberger, D.R. (1987) X-ray computed tomography and magnetic resonance imaging in psychiatry. In American Psychiatric Association Annual Review Vol. 6 (eds Hales, R.E. & Frances, A.J.) pp. 260–299. Washington DC: American Psychiatric Press.Google Scholar
Johnstone, E.C., Crow, T.J., Frith, C.D., et al (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet, ii, 924–926.Google Scholar
Kleinman, J.E., Karoun, S. & Rosenblat, J.E. (1982) Postmortem neurochemical studies in chronic schizophrenia. In Biological Markers in Psychiatry and Neurology (eds Usdin, E. & Hanin, I.). Oxford & New York: Pergamon Press.Google Scholar
Kraepelin, E. (1919) Dementia Praecox and Paraphrenia (Translated by R.M. Barkley). Edinburgh: E. & S. Livingstone.Google Scholar
Lecrubier, Y., Puech, A.J., Simon, P., et al (1980) Schizophrenia: hyper-ou hypofonctionnement de systeme dopaminergique: une hypothese bipolaire. Psychologie Medicale, 12, 2431–2441.Google Scholar
Mackay, A.V.P. (1980) Positive and negative schizophrenic symptoms and the role of dopamine. British Journal of Psychiatry, 137, 279–283.CrossRefGoogle ScholarPubMed
Mathew, R.J., Mayer, H.S., Francis, D.J., et al (1982) Regional cerebral blood flow in schizophrenia. Archives of General Psychiatry, 39, 1121–1124.Google Scholar
Meltzer, H.Y. (1987) Biological studies in schizophrenia. Schizophrenia Bulletin, 13, 77–114.Google Scholar
Nauta, W.J.H. (1971) The problem of the frontal lobe: a reinterpretation. Journal of Psychiatric Research, 8, 167–187.Google Scholar
Owen, F., Cross, A.J., Crow, T.J., Longen, A., Poulter, M. & Riley, G.J. (1978) Increased dopamine receptor sensitivity and monoamine metabolities in schizophrenic patients and healthy volunteers. Lancett, ii, 223–225.Google Scholar
Owens, D.G.C., Johnstone, E.C., Crow, T.J., et al (1985) Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychological Medicine, 15, 43–54.CrossRefGoogle Scholar
Pearlson, G.D., Garbacz, D.J., Breakey, W.R., et al (1984) Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Research, 12, 1–9.Google Scholar
Pearlson, G.D., Garbacz, D.J., Moberg, P.J., et al (1985) Symptomatic, familial, perinatal, and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars. Journal of Nervous and Mental Diseases, 173, 42–50.Google Scholar
Randrup, A. & Munkvad, I. (1965) Special antagonism of amphetamine-induced abnormal behavior: inhibition of stereotyped activity with increase of some normal activity. Psychopharmacologia, 7, 416–422.CrossRefGoogle Scholar
Rieder, R.O., Mann, L.S., Weinberger, D.R., et al (1979) Sulcal prominence in young chronic schizophrenic patients: CT scan findings associated with impairment on neuropsychological tests. Psychiatry Research, 1, 1–8.Google Scholar
Sedvall, G., Farde, L., Persson, A., et al (1986) Imaging of neurotransmitter receptors in the living human brain. Archives of General Psychiatry, 43, 995–1005.1.Google Scholar
Seeman, P., Lee, T., Chang-Wong, M., et al (1976) Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature, 261, 717–719.CrossRefGoogle ScholarPubMed
Seeman, P., Ulpian, C., Bergeron, C., et al (1984) Bimodal distribution of dopamine receptor densities in brains of schizophrenics. Science, 225, 728–768.Google Scholar
Sheppard, G., Gruzelier, J., Manchandra, R., et al (1983) O—15 positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet, ii, 1448–1452.Google Scholar
Snyder, S.H. (1976) The dopamine hypothesis in schizophrenia: focus on the dopamine receptor. American Journal of Psychiatry, 133, 197–202.Google Scholar
Stuss, D.T. & Benson, D.F. (1986) The Frontal Lobes. New York: Raven Press.Google Scholar
Van Kammen, D.P., Mann, L.S., Sternberg, D.E., et al (1983) Dopamine beta-hydroxylase activity and homovanillic acid in spinal fluid of patients with brain atrophy. Science, 220, 974–977.Google Scholar
Weinberger, D.R., Torrey, E.F., Neophytides, A.N., et al (1979a) Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735–739.CrossRefGoogle ScholarPubMed
Weinberger, D.R., Torrey, E.F., Neophytides, A.N., et al (1979b) Structural abnormalities of the cerebral cortex of chronic schizophrenic patients. Archives of General Psychiatry, 36, 935–939.Google Scholar
Weinberger, D.R., Cannon-Spoor, E., Potkin, S.G., et al (1980a) Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. American Journal of Psychiatry, 137, 1410–1423.Google ScholarPubMed
Weinberger, D.R., Bigelow, L.B., Kleinman, J.E., et al (1980b) Cerebral ventricular enlargement in chronic schizophrenia: an association with poor response to therapy. Archives of General Psychiatry, 37, 11–13.CrossRefGoogle Scholar
Weinberger, D.R., Wagner, R.L. & Wyatt, R.J. (1983) Neuropathological studies of schizophrenia: a selective review. Schizophrenia Bulletin, 9, 193–212.Google Scholar
Weinberger, D.R., Berman, K.F. & Zec, R.F. (1986) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow (rCBF) evidence. Archives of General Psychiatry, 43, 114–124.Google Scholar
Widen, L., Blomqvist, G., Greitz, T., et al (1983) PET studies of glucose metabolism in patients with schizophrenia. American Journal of Nuclear Radiology, 4, 550–552.Google Scholar
Wong, D.F., Gjedde, A. & Wagner, H.N. (1986a) Quantification of neuroreceptors in the living human brain: II. Inhabition studies of receptor density and affinity. Journal of Cerebral Blood Flow Metabolism, 6, 137–146.Google Scholar
Wong, D.F., Gjedde, A. & Wagner, H.N., et al (1986b) Quantification of neuroreceptors in the living human brain: II. Inhibition studies of receptor density and affinity. Journal of Cerebral Blood Flow Metabolism, 6, 147–153.CrossRefGoogle ScholarPubMed
Wong, D.F., Wagner, H.N., Tune, L.E., et al (1986c) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science, 234, 1558–1563.Google Scholar
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