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Need to identify modifiable risk factors of dementia in the older UK African–Caribbean population

Published online by Cambridge University Press:  02 January 2018

Om Prakash*
Affiliation:
Institute of Human Behaviour & Allied Sciences (IHBAS), New Delhi, India. Email: drjhirwalop@yahoo.co.in
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Abstract

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Columns
Copyright
Copyright © Royal College of Psychiatrists, 2011 

The article by Adelman and colleagues Reference Adelman, Blanchard, Rait, Leavey and Livingston1 made an important contribution in exploring dementia in older people of African–Caribbean origin in the UK. This article paves a way for policy makers in assessing the public health implications of this ubiquitous condition in terms of care burden and economic impact. However, this research study raises important issues.

Previous studies Reference Adelman, Blanchard and Livingston2 consistently indicate increased prevalence of dementia in older African–Caribbean people when compared with the indigenous White population in the UK. The magnitude of this difference between these populations is not clear. Hence, there is a definite need for well-planned epidemiological studies to determine the actual burden of disease. Surprisingly, Adelman et al’s study Reference Adelman, Blanchard, Rait, Leavey and Livingston1 presumed that vascular factors such as hypertension and type 2 diabetes are likely to increase the burden of dementia in the African–Caribbean population. However, the possibility of other risk factors such as depression, illiteracy and prevalence of apolipoprotein 4, which, presumably, increase the chances of subsequent dementia, needs more emphasis. Reference Stewart, Russ, Richards, Brayne, Lovestone and Mann3,Reference Kalaria, Maestre, Arizaga, Friedland, Galasko and Hall4 Current data from sub-Saharan Africa and India Reference Kalaria, Maestre, Arizaga, Friedland, Galasko and Hall4 suggest that age-adjusted dementia prevalence estimates in 65-year-olds are low (1–3%) compared with other low- and middle-income countries. It appears that there is a need to identify potentially modifiable environmental/genetic factors to explain the increased prevalence of dementia when this population migrated to the UK. Therefore, future studies are needed to identify these risk factors in this migrant population.

References

1 Adelman, S, Blanchard, M, Rait, G, Leavey, G, Livingston, G. Prevalence of dementia in African–Caribbean compared with UK-born White older people: two-stage cross-sectional study. Br J Psychiatry 2011; Jun 8: doi: 10.1192/bjp.bp.110.086405. Epub ahead of print.Google Scholar
2 Adelman, S, Blanchard, M, Livingston, G. A systematic review of the prevalence and covariates of dementia or relative cognitive impairment in the older African-Caribbean population in Britain. Int J Geriatr Psychiatry 2009; 24: 657–65.Google Scholar
3 Stewart, R, Russ, C, Richards, M, Brayne, C, Lovestone, S, Mann, A. Depression, APOE genotype and subjective memory impairment: a cross-sectional study in an African-Caribbean population. Psychol Med 2001; 31: 431–40.CrossRefGoogle Scholar
4 Kalaria, RN, Maestre, GE, Arizaga, R, Friedland, RP, Galasko, D, Hall, K, et al. Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol 2008; 7: 812–26.CrossRefGoogle ScholarPubMed
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