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Linkage between Glucose-6-Phosphate Dehydrogenase Deficiency and Manic-Depressive Psychosis

Published online by Cambridge University Press:  29 January 2018

J. Mendlewicz ,
P. Linkowski  and
J. Wilmotte
J. Mendlewicz
Affiliation:
Department of Psychiatry, Erasme Hospital, Free University of Brussels, 808 Route de Lennick, 1070 Brussels, Belgium
P. Linkowski
Affiliation:
Department of Psychiatry, Erasme Hospital, Free University of Brussels, 808 Route de Lennick, 1070 Brussels, Belgium
J. Wilmotte
Affiliation:
Department of Psychiatry, Civil Hospital, Charleroi, and University of Brussels, Belgium
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Summary

Heredity has been shown to be an important factor in the aetiology of manic-depressive psychosis. Recent linkage studies with colour blindness have suggested the presence of an X-linked dominant gene in the transmission of manic-depressive psychosis. We report here positive evidence of a linkage between manic-depressive psychosis and glucose-6-phosphate dehydrogenase deficiency in an informative family assorting for both traits. These results strengthen previous linkage studies in affective illness and support the hypothesis of X-linkage in a subgroup of manic-depressive psychosis.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 4 , October 1980 , pp. 337 - 342
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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