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L-Deprenil, A Selective Monoamine Oxidase Type B Inhibitor, in the Treatment of Depression: A Double Blind Evaluation

Published online by Cambridge University Press:  29 January 2018

J. Mendlewicz  and
M. B. H. Youdim
J. Mendlewicz
Affiliation:
Erasme Hospital, Free University of Brussels, 808 Route de Lennik, B–1070 Brussels, Belgium
M. B. H. Youdim
Affiliation:
The Aba Khouchy School of Medicine, University of Haifa, Bat-Galim, Haifa, Israel
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Summary

In a double blind controlled study, 14 affectively ill patients (2 bipolars, 12 unipolars) were randomly allocated to L-Deprenil treatment (an irreversible selective MAO-B inhibitor without “cheese effect”) and 13 patients (3 bipolars, 10 unipolars) to placebo only. Patients on L-Deprenil showed a significantly greater clinical improvement than placebo patients. A positive relationship was found between clinical improvement and degree of platelet MAO inhibition in patients treated with L-Deprenil.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 142 , Issue 5 , May 1983 , pp. 508 - 511
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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