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Extrapyramidal Syndromes and New Antipsychotic Drugs: Findings in Patients and Non-human Primate Models

Published online by Cambridge University Press:  06 August 2018

Daniel E. Casey
Daniel E. Casey*
Affiliation:
Oregon Health Sciences University, and Psychiatric Research and Psychopharmacology, Veterans Administration Medical Center, Portland, USA
*
Professor Daniel E. Casey, MD, Psychiatry Service (116A), VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97201, USA
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Extract

Since neuroleptic drugs were introduced in the 1950s they have become the primary mode of therapy for managing both acute and chronic psychoses. Although some antipsychotic drugs are free of disturbing extrapyramidal side-effects (EPS), most have a very narrow therapeutic/toxic index. Clozapine is the best example of an antipsychotic with a wide separation between antipsychotic actions and liability to EPS, but its side-effect profile of sedation, salivation, seizures, and agranulocytosis are factors that limit its use, and clearly indicate the need for further advancement in neuroleptic therapy.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 168 , Issue S29: Current Issues in the Development of Atypical Antipsychotic Drugs , May 1996 , pp. 32 - 39
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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