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Childhood/early adolescence-onsetand adult-onset schizophrenia

Heterogeneity at the dopamine D3 receptor gene

Published online by Cambridge University Press:  02 January 2018

Michel Maziade ,
Maria Martinez ,
Caroline Rodrigue ,
Benoît Gauthier ,
Guy Tremblay ,
Christiane Fournier ,
Luc Bissonnette ,
Carl Simard ,
Marc-André Roy  and
Eric Rouillard
...Show all authors
Michel Maziade*
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada
Maria Martinez
Affiliation:
Centre de recherche Université Laval Robert-Giflard, Beauport, Québec, Canada and Epidémiologie génétique INSERM 358, Paris, France
Caroline Rodrigue
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada
Benoît Gauthier
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada and Hôtel-Dieu du Sacré-Coeur, Québec, Québec, Canada
Guy Tremblay
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada and Hôtel-Dieu du Sacré-Coeur, Québec, Québec, Canada
Christiane Fournier
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada and Hôtel-Dieu du Sacré-Coeur, Québec, Québec, Canada
Luc Bissonnette
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada
Carl Simard
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada
Marc-André Roy
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada
Eric Rouillard
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada
Chantal Mérette
Affiliation:
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada
*
Dr Michel Maziade, Centre de recherche Université Laval Robert-Giffard, 2601, de la Canardiere, Beauport, Québec, Canada GIJ2G3
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Abstract

Background

The dopamine D3 receptor gene (DRD3) is a meaningful candidate gene because it unifies the dopamine and the limbic hypotheses for schizophrenia. We tested for an allelic association between schizophrenia and the DRD3 Mscl alleles, hypothesising heterogeneity between childhood/early adolescence-onset schizophrenia (CO-SZ) and adult-onset schizophrenia (A-SZ).

Method

The frequencies of the DRD3 alleles were compared between 70 DSM-III-R schizophrenics (35 CO-SZ and 35 A-SZ) and 79 controls.

Results

Compared with the controls, the subsample of A-SZ, but not CO-SZ, showed an over-proportion (P = 0.025) of allele 1. The association was not found in the total sample, combining the two subsamples.

Conclusions

Consistently with former studies, our data suggest an aetiological heterogeneity between CO-SZ and A-SZ and a possible specificity of the excess of allele 1 to the familial form of schizophrenia and to schizophrenia with a better outcome.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 1 , January 1997 , pp. 27 - 30
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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