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Serum Immunoglobulins and Cognitive Status in the Elderly: 2. An Immunological-Behavioral Relationship?

Published online by Cambridge University Press:  29 January 2018

Carl Eisdorfer
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA
Donna Cohen
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA


In 42 patients with cognitive dysfunction (senile dementia) significant correlations between immunoglobulins and various tests of intelligence were observed. Serum IgG emerged as the single best predictor of behavioural status. There is need for further research in this field.

Copyright © The Royal College of Psychiatrists 

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Buckley, C. E., Buckley, E. G. & Dorsey, F. C. (1974) Longitudinal changes in serum immunoglobulin levels in older humans. Fed. Proc., 33, 2036–9.Google ScholarPubMed
Buckley, C. E. & Roseman, J. M. (1976) Immunity and survival. J. Am. Ger. Soc., XXIV, 241–8.Google Scholar
Cohen, D. (1977) Sex differences in spatial performance in the elderly: a review of the literature and suggestions for research. Educ. Geront., 2, 5970.CrossRefGoogle Scholar
Cohen, D. & Eisdorfer, C. (1977) Behavioural-immunologic relationships in older men and women. Exp. Ageing Res., 3, 225–9.CrossRefGoogle ScholarPubMed
Cohen, D., Matsuyama, S. & Jarvik, L. F. (1976) Immunoglobulin levels and intellectual functioning in the aged. Exp. Ageing Res., 2, 345–8.CrossRefGoogle ScholarPubMed
Cohen, D. & Wilkie, F. (In press) Sex differences in cognition in the elderly. In Determinants of Sex-related Differences in Cognitive Functioning. (Eds. M. Wittig and A. Peterson). New York: Academic Press.Google Scholar
Eddington, T. S. & Dalessio, D. J. (1970) The assessment of immunofluorescence methods of humoral and antimyelin antibodies in men. J. Immunol., 105, 248–55.Google Scholar
Eisdorfer, C., Cohen, D. & Buckley, C. E. (1978) Behavioural-serum immunoglobulins relationship in the cognitively impaired elderly. In Alzheimer's Disease, Senile Dementia and Related Disorders. (Eds. R. Katzman and R. D. Terry). New York: Raven.Google Scholar
Heath, R. G. & Krupp, I. M. (1967) Schizophrenia as an immunologic disorder. Arch. Gen. Psychiat., 16, 19.CrossRefGoogle ScholarPubMed
Hooper, E. H. (1957) Hooper Visual Organization Test. Los Angeles: Western Psychological Service.Google Scholar
Hushy, G., Rijn, Ive, Zabriskia, J. B., Aldin, Z. H. & Williams, R. C. (1976) Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J. Exp. Med., 144, 1094–110.Google Scholar
Ingram, C. R., Phegan, K. J. & Blumenthal, H. T. (1974) Significance of an ageing-linked neuron-binding gamma-globulin fraction of human sera. J. Geront., 29, 20–7.CrossRefGoogle Scholar
Nandy, K. (1972) Neuronal degreneration in ageing and after experimental injury. Exp. Geront., 7, 303–11.CrossRefGoogle Scholar
Nandy, K. (1972) Brain-reactive antibodies in mouse serum as a function of age. J. Geront., 27, 173–7.CrossRefGoogle ScholarPubMed
Nandy, K. (1978) Brain-reactive antibodies. In Alzheimer's Disease, Senile Dementia and Related Disorders. (Eds. R. Katzman and R. D. Terry). New York: Raven.Google Scholar
Nandy, K. (1972) Brain-reactive antibodies in serum of germ-free mice. Mech. Age Rev., 1, 133–8.Google Scholar
Nandy, K. (1977) Immune reaction in the ageing brain and senile dementia. In The Ageing Brain and Senile Dementia. (Eds. K. Nandy and I. Sherwin). New York: Plenum.CrossRefGoogle Scholar
Nandy, K. (1975) Significance of brain-reactive antibodies in serum of aged mice. J. Geront., 30, 412–16.Google ScholarPubMed
Nandy, K., Fritz, R. B. & Threatt, J. (1975) Specificity of brain-reactive antibodies in serum of old mice. J. Geront., 30, 269–74.Google ScholarPubMed
Roseman, J. M. & Buckley, C. E. (1975) Inverse relationship between serum IgG concentrations and measures of intelligence in elderly persons. Nature, 254, 55–6.CrossRefGoogle ScholarPubMed
Shader, R. J., Harmatz, J. S. & Salzman, C. (1974) A new scale for clinical assessment in geriatric patients: Sandoz clinical assessment-geriatric (SCAG). J. Amer. Ger. Soc., 22, 107–13.CrossRefGoogle Scholar
Solomon, G. F., Amkraut, A. A. & Kasper, D. (1974) Immunity, emotions, and stress. Ann. Clinic. Res., 6, 313–22.Google ScholarPubMed
Strahilevitz, M., Fleischman, J. B., Fischer, G. W., Harris, R. & Norasihchari, N. (1976) Immunoglobulin levels in psychiatric patients. Am. J. Psychiatr., 133, 772–7.Google ScholarPubMed
Stein, M., Schiavi, R. C. & Camerino, M. (1976) Influence of brain and behaviour on the immune system. Science, 191, 435, 440.CrossRefGoogle ScholarPubMed
Wechsler, D. (1945) A standardized memory scale for clinical use. J. Psychol., 19, 8795.Google Scholar
Wechsler, D. (1955) Manual for the Wechsler Adult Intelligence Scale. New York: Psychological Corporation.Google Scholar
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