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The Effects of Clozapine on Tardive Dyskinesia

Published online by Cambridge University Press:  03 January 2018

Jeffrey A. Lieberman*
Hillside Hospital, Glen Oaks, New York, and Associate Professor of Psychiatry, Albert Einstein School of Medicine, New York
Bruce L. Saltz
Hillside Hospital, New York, and Associate Professor of Psychiatry, Albert Einstein College of Medicine, New York
Celeste A. Johns
Hillside Hospital, New York
Simcha Pollack
Hillside Hospital, New York, and Associate Professor of Statistics, St John's University, Jamaica, New York
Michael Borenstein
Hillside Hospital, New York
John Kane
Department of Psychiatry, Hillside Hospital, New York, and Professor of Psychiatry, Albert Einstein School of Medicine, New York, USA
Hillside Hospital, Division of Long Island Jewish Medical Center, PO Box 38, Glen Oaks, New York, USA


This article reviews eight published studies that describe clozapine's effects on TD and examines the outcome of 30 patients with TD treated with clozapine for up to 36 months. These data indicate that TD response to clozapine is variable but that approximately 43% of cases, particularly those with dystonic features, improved after clozapine treatment. Methodological limitations of the studies described, however, preclude definitive conclusions, which must await appropriately controlled trials.

Research Article
Copyright © Royal College of Psychiatrists, 1991 

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