Skip to main content Accessibility help
×
Home
Hostname: page-component-79b67bcb76-c2bf7 Total loading time: 0.258 Render date: 2021-05-14T13:00:45.202Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Dementia Praecox Revisited

Age Disorientation, Mental Status, and Ventricular Enlargement

Published online by Cambridge University Press:  02 January 2018

Terry E. Goldberg
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Neurosciences Research Center at St Elizabeths, 2700 Martin Luther King Avenue, Washington DC 20032, USA
Joel E. Kleinman
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Neurosciences Research Center at St Elizabeths, 2700 Martin Luther King Avenue, Washington DC 20032, USA
David G. Daniel
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Neurosciences Research Center at St Elizabeths, 2700 Martin Luther King Avenue, Washington DC 20032, USA
Michael S. Myslobodsky
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Neurosciences Research Center at St Elizabeths, 2700 Martin Luther King Avenue, Washington DC 20032, USA
John D. Ragland
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Neurosciences Research Center at St Elizabeths, 2700 Martin Luther King Avenue, Washington DC 20032, USA
Daniel R. Weinberger
Affiliation:
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Neurosciences Research Center at St Elizabeths, 2700 Martin Luther King Avenue, Washington DC 20032, USA

Abstract

Thirty-nine patients with DSM–III diagnoses of schizophrenia were examined for age disorientation, an inability to produce one's correct chronological age upon request. Six patients were age-disoriented and demented (as defined by Mini-Mental State evaluation), while two patients had delusions concerning their age, but were not demented. Age-disoriented, demented patients had very large cerebral ventricles and very low Mini-Mental State scores. This group differed on the cognitive and neuroanatomic variables from other demented, but not age-disoriented, patients, as well as from non-demented patients who were age-oriented. The age-disoriented patients appeared to be at an extreme end of the dementia spectrum in schizophrenia.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1988 

Access options

Get access to the full version of this content by using one of the access options below.

References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google ScholarPubMed
Crow, T. J. & Mitchell, W. S. (1975) Subjective age in chronic schizophrenia: evidence for a subgroup of patients with defective learning. British Journal of Psychiatry, 126, 360363.CrossRefGoogle Scholar
Donnelly, E. F., Weinberger, D. R., Waldman, I. N. & Wyatt, R. J. (1980) Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients. Journal of Nervous and Mental Disease, 168, 305308.CrossRefGoogle ScholarPubMed
Folstein, M. F., Folstein, S. E. & McHugh, P. (1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.CrossRefGoogle ScholarPubMed
Fox, J. H., Kaszniak, A. W. & Huckman, M. (1979) Computerized tomographic scanning not very helpful in dementia. New England Journal of Medicine, 300, 437.Google ScholarPubMed
Golden, C. J., Moses, J. A., Zelazowski, R., Graber, B., Zatz, L. M., Horvath, T. V. & Berger, P. A. (1980) Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: measurement by the standardized Luria–Nebraska Neuropsychological Battery. Archives of General Psychiatry, 37, 619623.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J. & Kreel, L. (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. The Lancet, ii, 924926.CrossRefGoogle Scholar
Johnstone, E. C., Crow, T. J., Frith, C. D., et al (1978) The dementia of dementia praecox. Acta Psychiatrica Scandinavica, 57, 305324.CrossRefGoogle ScholarPubMed
Liddle, P. F. & Crow, T. J. (1984) Age disorientation in chronic schizophrenia is associated with global intellectual impairment. British Journal of Psychiatry, 144, 193199.CrossRefGoogle ScholarPubMed
Shallice, T. & Evans, M. E. (1978) The involvement of the frontal lobes in cognitive estimation. Cortex, 14, 294303.CrossRefGoogle ScholarPubMed
Shelton, R. C., Karson, C. N., Doran, A. R., Pickar, D., Bigelow, L. B. & Weinberger, D. R. (1988) Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical deficit in schizophrenia. American Journal of Psychiatry, 145, 154163.Google Scholar
Stevens, M., Crow, T. J., Bowman, M. J. & Coles, E. C. (1978) Age disorientation in schizophrenia: a constant prevalence of about 25% in a chronic mental hospital population? British Journal of Psychiatry, 133, 130136.CrossRefGoogle Scholar
Synek, V. M. & Reuben, J. R. (1976). The ventricular–brain ratio using planimetric measurements of EMI scans. British Journal of Radiology, 49, 233237.CrossRefGoogle ScholarPubMed
Weinberger, D. R., Torrey, E. F. & Neophytides, A. N. (1979) Lateral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735739.CrossRefGoogle ScholarPubMed
Wyatt, R. J. (1976) Biochemistry and schizophrenia (part iv). The neuroleptics – their mechanism of action: a review of the biochemical literature. Psychopharmacology Bulletin, 12, 550.Google ScholarPubMed
Zatz, L. M., Jernigan, T. C. & Ahumada, A. J. Jr (1982) Changes on computed tomography with aging: intracranial fluid volume. American Journal of Neuroradiology, 3, 111.Google ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Dementia Praecox Revisited
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Dementia Praecox Revisited
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Dementia Praecox Revisited
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *