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CSF Neuropeptides in Euthymic Bipolar Patients and Controls

Published online by Cambridge University Press:  02 January 2018

Wade H. Berrettini*
Intramural Research Program
John I. Nurnberger Jr.
Intramural Research Program
Robert L. Zerbe
Lilly Research Centre, Ltd, Surrey, UK
Philip W. Gold
IRP NIMH, National Institute of Health, Bethesda
George P. Chrousos
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda
Thomas Tomai
IRP NIMH, National Institute of Health, Bethesda
National Institute of Mental Health, Bethesda, Maryland 20205, USA


Levels of vasopressin, somatostatin, neurotensin, vasoactive intestinal peptide, corticotrophin-releasing factor and adrenocorticotrophin in CSF were determined in lithium-treated and unmedicated euthymic bipolar patients and controls, in a search for a trait marker in affective disorder. No group differences in levels of these peptides were found. Highly significant positive correlations were found among these peptides (with the exception of neurotensin), suggesting that their presence in CSF is functionally significant, as opposed to the result of random diffusion from the interstitial space of the brain.

Research Article
Copyright © 1987 The Royal College of Psychiatrists 

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