Hostname: page-component-848d4c4894-8kt4b Total loading time: 0 Render date: 2024-06-24T22:37:55.032Z Has data issue: false hasContentIssue false
  • English
  • Français

The Abrupt Withdrawal of Antiparkinsonian Drugs in Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

H. A. McClelland ,
G. Blessed ,
N. Ali ,
S. Bhate  and
P. A. Clarke
H. A. McClelland
Affiliation:
Newcastle upon Tyne University Hospitals Group
G. Blessed
Affiliation:
Newcastle upon Tyne University Hospitals Group
N. Ali
Affiliation:
Newcastle upon Tyne University Hospitals Group
S. Bhate
Affiliation:
Newcastle upon Tyne University Hospitals Group
P. A. Clarke
Affiliation:
Newcastle Regional Hospital Board St. Nicholas, Gosforth, Newcastle upon Tyne, NE3 3XT
Get access Rights & Permissions [Opens in a new window]

Extract

Phenothiazines and other neuroleptic drugs are known to cause extrapyramidal side-effects. Consequently antiparkinsonian (AP) drugs are commonly prescribed at the same time as antipsychotic medication in order to prevent these complications. Once this medication has been started it may be continued for prolonged periods.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 124 , Issue 579 , February 1974 , pp. 151 - 159
Copyright
Copyright © Royal College of Psychiatrists, 1974 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ananth, J. V., Horodesky, J., Lechman, H. E., and Bon, T. A. (1970). ‘Effect of withdrawal on chronically hospitalized psychiatric patients.’ Laval méd., 41, 934–8.Google ScholarPubMed
Ayd, F. J. (1961). ‘A survey of drug-induced extrapyramidal reactions.’ J. Amer. med. Ass., 175, 1054–60.CrossRefGoogle ScholarPubMed
Cahan, R. B., and Parrish, D. D. (1960). ‘Reversibility of drug-induced parkinsonism.’ Amer. J. Psychiat., 116, 1022–3.CrossRefGoogle ScholarPubMed
DiMascio, A., and Demirgian, E. (1970). ‘Antiparkinson drug overuse.’ Psychosomatics, 11, 596–601.CrossRefGoogle ScholarPubMed
Ekdawi, M. Y., and Fowke, R. (1966). ‘A controlled trial of antiparkinson drugs in drug-induced parkinsonism.’ Brit. J. Psychiat., 112, 633–6.CrossRefGoogle ScholarPubMed
Kennedy, P. F., Hershon, H. I., and McGuire, R. S. (1971). ‘Extrapyramidal disorders after prolonged phenothiazine therapy.’ Brit. J. Psychiat., 118, 509–18.CrossRefGoogle ScholarPubMed
Klett, G. J., and Caffey, E. (1972). ‘Evaluating the long-term need for antiparkinson drugs by chronic schizophrenics.’ Arch. gen. Psychiat., 26, 374–9.CrossRefGoogle ScholarPubMed
Mandel, W., Claffey, B., and Margolis, L. H. (1961). ‘Recurrent thioperazine-induced extrapyramidal reaction following placebo substitution for maintenance antiparkinson drug.’ Amer. J. Psychiat., 118, 351–2.Google ScholarPubMed
Mandel, W., and Oliver, W. A. (1961). ‘Withdrawal of maintenance antiparkinson drug in the phenothiazine induced extrapyramidal reaction.’ Amer. J. Psychiat., 118, 350–1.Google ScholarPubMed
National Institute of Mental Health (1964). ‘Psychopharmacology Service Centre Collaborative Study Group.’ Arch. gen. Psychiat., 10, 246.Google Scholar
Orlov, P., Kasporian, G., DiMascio, A., and Cole, N. O. (1971). ‘Withdrawal of antiparkinson drugs.’ Arch. gen. Psychiat., 25, 410–2.CrossRefGoogle ScholarPubMed
St. Jean, A., Donald, M., and Bann, T. A. (1961). ‘A survey of drug-induced extrapyramidal reactions.’ J. Amer. med. Ass., 175, 102–8.Google Scholar
St. Jean, A., Donald, M., and Bann, T. A. (1984). ‘Interchangeability of antiparkinson medication.’ Amer. J. Psychiat., 120, 1189–90.Google Scholar
Shepherd, M., Lader, M., and Rodnioht, R. (1968). Clinical Psychopharmacology. London: English Universities Press.Google Scholar
Stephens, D. A. (1967). ‘Psychotoxic effects of benzhexol hydrochloride (Artane).’ Brit. J. Psychiat., 113, 213–8.CrossRefGoogle ScholarPubMed
Stratas, N. E., Phillips, R. D., Walker, P. A., and Sandifer, M. G. (1963). ‘A study of drug-induced parkinsonism.’ Dis. nerv. Syst., 24, 180.Google ScholarPubMed
Wing, J. K. (1961). ‘A simple and reliable subclassification of chronic schizophrenia.’ J. ment. Sci., 107, 862–6.CrossRefGoogle ScholarPubMed
Wing, J. K. and Brown, G. W. (1970). Institutionalism and Schizophrenia. Cambridge University Press.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.