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Identifying Perceptual, Motor, and Cognitive Components Contributing to Slowness of Information Processing in Multiple Sclerosis with and without Depressive Symptoms

Published online by Cambridge University Press:  19 June 2020

Genny Lubrini Open the ORCID record for Genny Lubrini [Opens in a new window] ,
José A. Periáñez ,
Mireya Fernández-Fournier ,
Antonio Tallón Barranco ,
Exuperio Díez-Tejedor ,
Ana Frank García  and
Marcos Ríos-Lago
Genny Lubrini*
Affiliation:
Universidad Complutense (Spain)
José A. Periáñez
Affiliation:
Universidad Complutense (Spain)
Mireya Fernández-Fournier
Affiliation:
Hospital Universitario La Paz (Spain)
Antonio Tallón Barranco
Affiliation:
Hospital Universitario La Paz (Spain)
Exuperio Díez-Tejedor
Affiliation:
Hospital Universitario La Paz (Spain)
Ana Frank García
Affiliation:
Hospital Universitario La Paz (Spain)
Marcos Ríos-Lago
Affiliation:
Universidad Nacional de Educación a Distancia (UNED) (Spain) Hospital Beata María Ana (Spain)
*
Correspondence concerning this article should be addressed to Genny Lubrini. Departamento de Psicología Experimental, Procesos Cognitivos y Logopedia de la Universidad Complutense. Madrid (Spain). E-mail: glubrini@ucm.es
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Abstract

Increasing findings suggest that different components of the stimulus-response pathway (perceptual, motor or cognitive) may account for slowed performance in Multiple Sclerosis (MS). It has also been reported that depressive symptoms (DS) exacerbate slowness in MS. However, no prior studies have explored the independent and joint impact of MS and DS on each of these components in a comprehensive manner. The objective of this work was to identify perceptual, motor, and cognitive components contributing to slowness in MS patients with and without DS. The study includes 33 Relapsing-Remitting MS patients with DS, 33 without DS, and 26 healthy controls. Five information processing components were isolated by means of ANCOVA analyses applied to five Reaction Time tasks. Perceptual, motor, and visual search components were slowed down in MS, as revealed by ANCOVA comparisons between patients without DS, and controls. Moreover, the compounding effect of MS and DS exacerbated deficits in the motor component, and slowed down the decisional component, as revealed by ANCOVA comparisons between patients with and without DS. DS seem to exacerbate slowness caused by MS in specific processing components. Identifying the effects of having MS and of having both MS and DS may have relevant implications when targeting cognitive and mood interventions.

Keywords

depressioninformation processing speedmultiple sclerosisreaction timeslowness
Type
Research Article
Information
The Spanish Journal of Psychology , Volume 23 , 2020 , e21
Copyright
© Universidad Complutense de Madrid and Colegio Oficial de Psicólogos de Madrid 2020

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