Skip to main content Accessibility help
Hostname: page-component-568f69f84b-klmjj Total loading time: 0.406 Render date: 2021-09-18T14:58:14.850Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Motor neurone disease

Published online by Cambridge University Press:  17 November 2008

Hardev S Pall*
University of Birmingham. Birmingham, UK
Hardev S Pall University Department of Clinical Neuroscience and Regional Centre for Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.


Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Clinical geriatrics
Copyright © Cambridge University Press 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)


1Hudson, AJ. Amyotrophic lateral sclerosis and its association with dementia, parkinsonism and other neurological disorders: a review. Brain 1981; 104: 217–47.CrossRefGoogle ScholarPubMed
2Salazar, AM, Masters, CL, Gajdusek, DC, Gibbs, CJ. Syndromes of amyotrophic lateral sclerosis and dementia: relation to transmissible Creutzfeldt–Jakob disease. Ann Neurol 1983; 14: 1726.CrossRefGoogle ScholarPubMed
3Hayashi, H, Kato, S, Kawada, T, Tsubaki, T. Amyotrophic lateral sclerosis: oculomotor function in patients on respirators. Neurology 1987; 37: 1431–32.CrossRefGoogle ScholarPubMed
4Swash, M, Leigh, N. Criteria for diagnosis of familial amyotrophic lateral sclerosis (workshop report of the European FALS Collaborative Group). Neuromuscul Disord 1992; 2: 79.CrossRefGoogle Scholar
5La Spada, AR, Wilson, EM, Lubahn, DB et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991; 352: 7779.CrossRefGoogle ScholarPubMed
6Thomas, PK, Young, E, King, RHM. Sandhoff disease mimicking adult onset bulbospinal neuronopathy. J Neurol Neurosurg Psychiatry 1989; 52: 1103–106.CrossRefGoogle ScholarPubMed
7Sumner, AJ. Separating motor neurone diseases from pure motor neuropathies: multifocal motor neuropathy with persistent conduction block. Adv Neural 1991 56: 399403.Google ScholarPubMed
8Pall, HS. Metals and free radicals. In: Williams, AC ed. Motor neurone disease. London: Chapman nd Hall, 1994: 497534.Google Scholar
9Olivares, L, Esteban, ES, Alter, M. Mexican resistance to amyotrophic lateral sclerosis. Arch Neural 1972; 27: 397402.CrossRefGoogle ScholarPubMed
10Gunnarsson, LG, Palm, R. Motor neurone disease and heavy manual labour: an epidemiologie survey of Varmland County, Sweden. Neuroepidemiology 1984; 3: 195206.CrossRefGoogle Scholar
11Patten, BM, Zito, G, Harati, Y. Histological findings in motor neurone disease. Relation to clinically determined activity, duration and severity of disease. Arch Neural 1979; 36: 560564.CrossRefGoogle Scholar
12Leigh, PN, Whitwell, H, Garofalo, Q et al. Ubiquitin immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis: morphology, distribution and specificity. Brain 1991; 114: 775–88.CrossRefGoogle ScholarPubMed
13Heafield, MTE, Fearn, S, Steventon, GB et al. Plasma cysteine and sulphate levels in motor neurone, Parkinson's and Alzheimer's disease. Neurosci Lett 1990; 110: 216–20.CrossRefGoogle ScholarPubMed
14Perl, TM, Bedard, L, Kosatsky, T et al. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. New Engl J Med 1990; 322: 1775–80.CrossRefGoogle ScholarPubMed
15Jubelt, B. Viruses and motor neurone diseases. Adv Neurol 1991; 56: 463–72.Google Scholar
16Appel, SH, Stockton-Appel, V, Stewart, SS et al. Amyotrophic lateral sclerosis: associated clinical disorders and immunologic evaluations. Arch Neural 1986; 43: 234–38.CrossRefGoogle Scholar
17Appel, SH, Engelhardt, JI, Garcia, J et al. Immunoglobulins from animal models of motor neurone disease and from human amyotrophic lateral sclerosis patients passively transfer physiological abnormalities to the neuromuscular junction. Proc Natl Acad Sci USA 1991; 88: 647–51.CrossRefGoogle ScholarPubMed
18Rosen, DR, Siddique, T, Patterson, D et al. Mutations in Cu Zn Superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993; 362: 5962.CrossRefGoogle ScholarPubMed
19Pall, HS, Williams, AC, Chirico, S et al. Concentrations of reduced and oxidised forms of ascorbic acid in serum and cerebrospinal fluid from patients with motor neurone disease. Neurology 1990; 40 (suppl 1): 317.Google Scholar
20Rothstein, JD, Kuncl, RW, Chaudhry, V et al. Excitatory amino acids in amyotrophic lateral sclerosis: an update. Ann Neural 1991; 30: 224–25.CrossRefGoogle ScholarPubMed
21Sobue, G, Sahashi, K, Takahashi, A et al. Degenerating compartment and functioning compartment of motor neurones in ALS: possible process of motor neurone loss. Neurology 1983; 33: 654–57.CrossRefGoogle Scholar
22Brooks, BR, Lewis, D, Rawling, J et al. The natural history of amyotrophic lateral sclerosis. In: Williams, AC ed. Motor neurone disease London: Chapman and Hall, 1994: 131–69.Google Scholar
23Bensimon, G, Lacomblez, L, Meininger, V et al. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med 1994; 330: 585–91.CrossRefGoogle ScholarPubMed
24Brewin, TB. Three ways of giving bad news. Lancet 1991; 337: 1207–209.CrossRefGoogle ScholarPubMed
25Jowett, S, Armitage, S. Hospital and community liaison links in nursing: the role of the liaison nurse. J Adv Nurs 1988; 13: 579–87.CrossRefGoogle ScholarPubMed
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Motor neurone disease
Available formats

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Motor neurone disease
Available formats

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Motor neurone disease
Available formats

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *