Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-28T10:59:28.554Z Has data issue: false hasContentIssue false
  • English
  • Français

Cellular dosimetry of strontium-90 using the Monte Carlo code MCNPX, detection and X-ray microanalysis

Published online by Cambridge University Press:  10 January 2014

N. Hocine ,
D. Farlay ,
J.-M. Bertho ,
G. Boivin ,
A. Desbrée ,
D. Franck  and
M. Agarande
N. Hocine*
Affiliation:
IRSN, BP17, 92260 Fontenay-aux-Roses, France
D. Farlay
Affiliation:
INSERM UMR 1033, 69008 Lyon, France Université de Lyon, 69008 Lyon, France
J.-M. Bertho
Affiliation:
IRSN, BP17, 92260 Fontenay-aux-Roses, France
G. Boivin
Affiliation:
INSERM UMR 1033, 69008 Lyon, France Université de Lyon, 69008 Lyon, France
A. Desbrée
Affiliation:
IRSN, BP17, 92260 Fontenay-aux-Roses, France
D. Franck
Affiliation:
IRSN, BP17, 92260 Fontenay-aux-Roses, France
M. Agarande
Affiliation:
IRSN, BP17, 92260 Fontenay-aux-Roses, France
*
a nora.hocine@irsn.fr
Get access

Abstract

The aim of this study is to provide data that increase knowledge about the possible health effects of exposure to 90Sr contaminant in drinking water. 90Sr detection in the mouse bone model plays an important complementary role with computational dosimetry in these investigations. S-value (absorbed dose per unit cumulated activity) calculations using Monte Carlo (MC) simulations, 90Sr detection by liquid scintillation β counting in the femur bone and X-ray microanalysis were carried out. The present work is focused on using MCNPX and its validation at a cellular level. The cytoplasm (Cy), nucleus (N) and 90Sr radiation source were simulated with the MC code MCNPX. Cells are assumed to be spherical, with the radii of the cell and cell nucleus ranging from 2 to 10 μm. The S-value (in Gy/Bq.s) calculations were provided for a 90Sr source distributed uniformly in the cell nucleus or cytoplasm and for two source-target combinations (t←s). A comparison between the calculated MC results and the MIRD values agreed very well since the relative deviations are less than 4%. The earliest results of X-ray microanalysis indicated that the 90Sr was below the detection limit (<0.1%) in the bone tissue. However, the measurements by liquid scintillation showed the presence of 90Sr in the femur bone.

Keywords

cellular dosimetryMonte Carlo codeMCNPX90SrX-ray microanalysis
Type
Article
Information
Radioprotection , Volume 49 , Issue 2 , April 2014 , pp. 101 - 105
Copyright
© EDP Sciences, 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boivin, G., Farlay, D., Khebbab, M.T., Jaurand, X., Delmas, P.D., Meunier, P.J. (2010) In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization, Osteoporosis Int. 21, 667-677. Google ScholarPubMed
Cooper, E.L., Zeiller, E., Ghods-Esphahani, A., Makarewicz, M., Schelenz, R., Frindik, O., Heilgeist, M., Kalus, W. (1992) Radioactivity in food and total diet samples collected in selected settlements in the USSR, J. Environ. Radioact. 17 (2-3), 147-157. Google Scholar
Cullen D.E., Hubbell J.H., Kissel L.D. (1997) EPDL97: the evaluated photon data library, 97 version. Report UCRL-50400, 6, Rev. 5. Lawrence Livermore National Laboratory.
Doublier, A., Farlay, D., Khebbab, M.T., Jaurand, X., Meunier, P.J., Boivin, G. (2011) Distribution of strontium and mineralization in iliac bone biopsies from osteoporotic women treated long-term with strontium ranelate, Eur. J. Endocrinol. 165 (3), 469-476. Google ScholarPubMed
Goddu S.M., Howell R.G., Bouchet L.G., Bolch W.E., Rao D.V. (1997) MIRD Cellular S Values (Reston, VA: Society of Nuclear Medicine).
ICRP (1993) Age-dependent doses to members of the public from intake of radionuclides: part 2. Ingestion dose coefficients. A report of a task group of committee 2 of the international commission on radiological protection, Ann. ICRP 23 (3-4), 1-167.
Pelowitz D.B. (Ed.) (2005) MCNPX User’s Manual, Version 2.5.0. Los Alamos National Laboratory report LA-CP-05-0369 (April 2005).
Synhaeve, N., Stefani, J., Tourlonias, E., Dublineau, I., Bertho, J.M. (2011) Biokinetics of 90Sr after chronic ingestion in a juvenile and adult mouse model, Radiat. Environ. Biophys. 50, 501-511. Google Scholar
UNSCEAR (2011) Annex D: health effects due to radiation from the Chernobyl accident. Sources and effects of ionizing radiation. United Nations, New-York.
Weber D.A., Eckerman K.F., Dillman T., Ryman J.C. (1989) MIRD: radionuclide data and decay schemes. New York: Society of Nuclear Medicine.