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Lineages, quantal cell cycles, and the generation of cell diversity

Published online by Cambridge University Press:  17 March 2009

H. Holtzer ,
N. Rubinstein ,
S. Fellini ,
G. Yeoh ,
J. Chi ,
J. Birnbaum  and
M. Okayama
H. Holtzer
Affiliation:
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19174
N. Rubinstein
Affiliation:
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19174
S. Fellini
Affiliation:
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19174
G. Yeoh
Affiliation:
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19174
J. Chi
Affiliation:
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19174
J. Birnbaum
Affiliation:
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19174
M. Okayama
Affiliation:
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia, Pa. 19174
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Abstract

Most theories of determination or differentiation assume that embryonic cells differ from mature cells. Embryonic cells are thought to have metastable control mechanisms. These labile controls are believed to become progressively more stabilized as the cells differentiate. Zygote, blastula, neural plate, limb bud, somite, or ‘stem’ cells are conceived of as undifferentiated, totipotent, or multipotential cells. As such, these cells supposedly have available for activation a larger repertoire of phenotypic programmes than their progeny. A necessary corollary to this view is that the activation of one particular phenotypic programme out of the many available is a function of instructive exogenous inducing molecules.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 8 , Issue 4 , November 1975 , pp. 523 - 557
Copyright
Copyright © Cambridge University Press 1975

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