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Electrically gated ionic channels in lipid bilayers

Published online by Cambridge University Press:  17 March 2009

Gerald Ehrenstein  and
Harold Lecar
Gerald Ehrenstein
Affiliation:
Laboratory of Biophysics, IRP, National Institute of Neurological and Communicative Disorders and Stroke, National Institute of Health, Bethesda, Maryland 20014
Harold Lecar
Affiliation:
Laboratory of Biophysics, IRP, National Institute of Neurological and Communicative Disorders and Stroke, National Institute of Health, Bethesda, Maryland 20014
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Extract

The generation of action potentials in nerve and muscle requires cell membranes with steeply voltage-dependent ionic permeabilities. The voltage-dependent, ion-selective pathways responsible for excitation have been characterized for numerous excitable tissues such as nerve axon, muscle, electric organ, algae and epithelia (Aidley, 1971; Hodgkin, 1964; Cole, 1968). The process of activating ionic pathways by some stimulus, such as a change in membrane potential, is called gating.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 10 , Issue 1 , February 1977 , pp. 1 - 34
Copyright
Copyright © Cambridge University Press 1977

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