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The transmethylation and one-carbon cycle hypotheses of schizophrenia1

Published online by Cambridge University Press:  09 July 2009

J. R. Smythies
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Abstract

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Type
Editorial
Information
Psychological Medicine , Volume 13 , Issue 4 , November 1983 , pp. 711 - 714
Copyright
Copyright © Cambridge University Press 1983

References

Antun, F., Burnett, G. B., Cooper, A. J., Daly, R. J., Smythies, J. R. & Zeally, A. K. (1971 a). The effects of l-methionine (without MAOI) in schizophrenia. Journal of Psychiatric Research 8, 63–71.Google Scholar
Antun, F., Eccleston, D. & Smythies, J. R. (1971 b). Transmethylation processes in schizophrenia. In Brain Chemistry and Mental Disease (ed. Ho, B. T. and McIsaac, W. M.), pp. 61–71. Plenum: New York.CrossRefGoogle Scholar
Baldessarini, R. J., Stramentinoli, G. & Lipikski, J. F. (1979). Methylation hypothesis. Archives of General Psychiatry 36, 303–307.CrossRefGoogle ScholarPubMed
Baudry, M., Chast, F. & Schwartz, J. C. (1973). Studies on S-adenosyl-homocysteine inhibition of histamine transmethylation in brain. Journal of Neurochemistry 20, 13–21.Google Scholar
Beaton, J. & Morris, P. E. (1982). Developmental changes in the levels of N, N-dimethyltryptamine and related indolealkylamines in rat brain. Abstract, Society of Neuroscience.Google Scholar
Carl, G. F., Crews, E. L., Carmichael, S. M., Benesh, F. L. & Smythies, J. R. (1978). Four enzymes of one-carbon metabolism in blood cells of schizophrenics. Biological Psychiatry 13, 773–776.Google ScholarPubMed
Cato, A. C. B. & Burdon, R. H. (1979). Mammalian DNA methylation and a nuclear S-adenosyl L-methionine-dependent nuclease activity. Federation of European Biochemical Societies Letters 99, 33–38.Google Scholar
Checkley, S. A., Oon, M. C. H., Rodnight, R., Murphy, M. P., Williams, R. S. & Birley, J. L. T. (1979). Urinary excretion of dimethyltryptamine in liver disease. American Journal of Psychiatry 136, 439–441.CrossRefGoogle ScholarPubMed
Cohen, S., Nichols, A. & Wyatt, R. (1974). The administration of methionine to chronic schizophrenic patients: a review of ten studies. Biological Psychiatry 8, 109–221.Google ScholarPubMed
Doerfler, W. (1981). DNA methylation – a regulatory signal in eukarytic gene expression. Journal of General Virology 57, 1–20.Google Scholar
Furgeson, M. D., Dill, R. E. & Dorris, R. L. (1976). Importance of O-methylation in dopamine-induced motor and behavioural phenomena. Brain Research 105, 163–167.CrossRefGoogle Scholar
Gillin, J. C., Kaplan, J., Stillman, R. & Wyatt, R. J. (1976). The psychedelic model of schizophrenia: the case of N, N-dimethyltryptamine. American Journal of Psychiatry 133, 203–298.Google ScholarPubMed
Harrison, R. (1982). Stress elevation of brain and adrenal levels of non-polar tryptophan metabolites. Ph.D. Thesis: University of Alabama.Google Scholar
Ismail, L., Sargent, T. III, Dobson, E. L. & Pollycove, M. (1978). Altered metabolism of the methionine methyl group in the leukocytes of patients with schizophrenia. Biological Psychiatry 13, 649–660.Google Scholar
Kelsoe, J. R. JrTolbert, L. C., Crews, E. L. & Smythies, J. R. (1982). Kinetic evidence for decreased methionine adenosyltransferase activity in erythrocytes from schizophrenics. Journalof Neuroscience Research 8, 99–103.Google Scholar
Kety, S. S. (1959). Biochemical theories of schizophrenia. Science 129, 1528–1532, 1590–1596.Google Scholar
Kleene, S. J., Hobson, C. & Adler, J. (1979). Attractants and repellants influence methylation and demethylation of methyl-accepting chemotaxis proteins in an extract of Escherichia coil. Proceedings of the National Academy of Sciences, USA 76, 6309–6313.Google Scholar
Le Fur, G., Phau, T., Canton, T., Tur, C. & Uzar, A. (1981). Evidence for a coupling between dopaminergic receptors and phospholipid methylation in mouse B. lymphocytes. Life Sciences 29, 2737–2749.CrossRefGoogle ScholarPubMed
Schatz, R. A., Wilens, T. E. & Sellinger, O. Z. (1981). Decreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-L-homocysteine. Journal of Neurochemistry 36, 1739–1748.CrossRefGoogle ScholarPubMed
Smythies, J. R. (1960). Recent advances in the biochemistry of psychosis. Lancet ii, 1287–1289.Google Scholar
Smythies, J. R. (1966). Recent advances in the biochemistry of schizophrenia. Guy's Gazette 05 14, 2–7.Google Scholar
Smythies, J. R. (1967). Biochemical abnormalities associated with schizophrenia. Hospital Medicine 04, 573–577.Google Scholar
Smythies, J. R. (1969). Neurochemical aspects of information processing in the brain. Communications in Behavioral Biology 3, 241–256.Google Scholar
Smythies, J. R. (1980). Brain protein carboxyrnethylases and schizophrenia. Psychoneuroendocrinology 5, 177–178.Google Scholar
Smythies, J. R., Morin, R. D. & Brown, G. B. (1979). Identification of dimethyltryptamine and O-methylbufotenin in human cerebrospinal fluid by combined gas chromatography/mass spectrometry. Biological Psychiatry 14, 549–556.Google ScholarPubMed
Sprince, H., Parker, C. M., Jameson, D. & Josephs, J. A. Jr (1965). Effect of methionine on nicotinic acid and indoleacetic acid pathways of tryptophan metabolism in vivo. Proceedings of the Society for Experimental Biology and Medicine 119, 942–946.CrossRefGoogle ScholarPubMed
Springer, M. S., Goy, M. F. & Adler, J. (1979). Protein methylation in behavioral control mechanisms and in signal transduction. Nature 180, 279–284.CrossRefGoogle Scholar
Stramentinoli, G. & Baldessarini, R. J. (1978). Lack of enhancement of dimethyltryptamine formation in rat brain and rabbit lung in vivo by methionine or S-adenosylmethionine. Journal of Neurochemistry 31, 1015–1020.CrossRefGoogle ScholarPubMed
Strittmatter, W. J., Hirata, F. & Axelrod, J. (1979). Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Science 204, 1205–1207.Google Scholar
Toews, M. L., Goy, M. F., Springer, M. S. & Adler, J. (1979). Attractants and repellants control demethylation of methylated chemotaxis proteins in Escherichia coil. Proceedings of the National Academy of Sciences, USA 76, 5544–5548.CrossRefGoogle Scholar
Tolbert, L., Monti, J., O'Shields, H., Walter-Ryan, W., Meadows, D. & Smythies, J. R. (1983). Defective transmethylation and membrane lipids in schizophrenia. Psychopharmacology Bulletin (in the press).Google Scholar