Hostname: page-component-77c89778f8-gq7q9 Total loading time: 0 Render date: 2024-07-19T10:04:11.027Z Has data issue: false hasContentIssue false

A systematic review and meta-analysis of the evidence on inflammation in depressive illness and symptoms in chronic and end-stage kidney disease

Published online by Cambridge University Press:  18 October 2022

Simone Jayakumar*
Affiliation:
Center for Psychiatry and Mental Health, Wolfson Institute of Population Health, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK Department of Clinical Pharmacology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK
Stacey Jennings
Affiliation:
Center for Psychiatry and Mental Health, Wolfson Institute of Population Health, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK
Kristoffer Halvorsrud
Affiliation:
Department of Applied Health Research, University College London, London, UK
Christophe Clesse
Affiliation:
Center for Psychiatry and Mental Health, Wolfson Institute of Population Health, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK Department of Clinical Pharmacology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK
Muhammad Magdi Yaqoob
Affiliation:
Translational Medicine and Therapeutics, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK
Livia A. Carvalho
Affiliation:
Department of Clinical Pharmacology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK
Kamaldeep Bhui
Affiliation:
Center for Psychiatry and Mental Health, Wolfson Institute of Population Health, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK East London NHS Foundation Trust and Oxford Health NHS Foundation Trust, London, UK
*
Author for correspondence: Simone Jayakumar, E-mail: simone.jayakumar@qmul.ac.uk

Abstract

Background

Depression affects approximately 27% of adults with chronic kidney disease (CKD) and end-stage kidney failure (ESKF). Depression in this population is associated with impaired quality of life and increased mortality. The extent of inflammation and the impact on depression in CKD/ESKF is yet to be established. Through a systematic literature review and meta-analysis, we aim to understand the relationship between depression and inflammation in CKD/ESKF patients.

Methods

We searched nine electronic databases for published studies until January 2022. Titles and abstracts were screened against inclusion and exclusion criteria. Data extraction and study quality assessment was carried out independently by two reviewers. A meta-analysis was carried out where appropriate; otherwise a narrative review of studies was completed.

Results

Sixty studies met our inclusion criteria and entered the review (9481 patients included in meta-analysis). Meta-analysis of cross-sectional associations revealed significantly higher levels of pro-inflammatory biomarkers; C-reactive protein; Interleukin 6 (IL-6) and tumour necrosis factor-alpha in patients with depressive symptoms (DS) compared to patients without DS. Significantly lower levels of anti-inflammatory cytokine IL-10 were found in patients with DS compared to patients without DS. Considerable heterogeneity was detected in the analysis for most inflammatory markers.

Conclusion

We found evidence for an association of higher levels of pro-inflammatory and lower anti-inflammatory cytokines and DS in patients with CKD/ESKF. Clinical trials are needed to investigate whether anti-inflammatory therapies will be effective in the prevention and treatment of DS in these patients with multiple comorbidities.

Type
Original Article
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

*

L.A. Carvalho and Kamaldeep Bhui share senior co-authorship.

References

Alshogran, O. Y., Khalil, A. A., Oweis, A. O., Altawalbeh, S. M., & Alqudah, M. A. Y. (2018). Association of brain-derived neurotrophic factor and interleukin-6 serum levels with depressive and anxiety symptoms in hemodialysis patients. General Hospital Psychiatry, 53, 2531. doi:10.1016/j.genhosppsych.2018.04.003CrossRefGoogle ScholarPubMed
Armaly, Z., Farah, J., Jabbour, A., Bisharat, B., Qader, A. A., Saba, S., … Bowirrat, A. (2012). Major depressive disorders in chronic hemodialysis patients in Nazareth: Identification and assessment. Neuropsychiatric Disease and Treatment, 8, 329338. doi:10.2147/ndt.S31903Google ScholarPubMed
Atalay, H., Solak, Y., Biyik, M., Biyik, Z., Yeksan, M., Uguz, F., … Turk, S. (2010). Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients. International Urology and Nephrology, 42, 527536. doi:10.1007/s11255-009-9686-yCrossRefGoogle ScholarPubMed
Barros, A., Costa, B. E., Mottin, C. C., & D'Avila, D. O. (2016). Depression, quality of life, and body composition in patients with end-stage renal disease: A cohort study. Brazilian Journal of Psychiatry, 38, 301306. doi:10.1590/1516-4446-2015-1681CrossRefGoogle ScholarPubMed
Bell, J. A., Kivimaki, M., Bullmore, E. T., Steptoe, A., Consortium, M. R. C. I., & Carvalho, L. A. (2017). Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults. Translational Psychiatry, 7, e1208. doi:10.1038/tp.2017.155CrossRefGoogle ScholarPubMed
Bikbov, B., Purcell, C. A., Levey, A. S., Smith, M., Abdoli, A., Abebe, M., … Murray, C. J. L. (2020). Global, regional, and national burden of chronic kidney disease, 1990–2017: A systematic analysis for the global burden of disease study 2017. The Lancet, 395, 709733. doi:10.1016/S0140-6736(20)30045-3CrossRefGoogle Scholar
Borenstein, M., Hedges, L., Higgins, J., & Rothstein, H. (2009). Comprehensive meta-analysis (version 2) [Computer program]. Retrieved from https://www.metaanalysis.com/index.php?cart=BQYJ7015021.Google Scholar
Bornivelli, C., Aperis, G., Giannikouris, I., Paliouras, C., & Alivanis, P. (2012). Relationship between depression, clinical and biochemical parameters in patients undergoing haemodialysis. Journal of Renal Care, 38, 9397. doi:https://doi.org/10.1111/j.1755-6686.2012.00259.x.CrossRefGoogle ScholarPubMed
Bossola, M., Ciciarelli, C., Di Stasio, E., Conte, G. L., Antocicco, M., Rosa, F., & Tazza, L. (2012). Symptoms of depression and anxiety over time in chronic hemodialysis patients. Journal of Nephrology, 25, 689698. doi:10.5301/jn.5000042CrossRefGoogle ScholarPubMed
Bossola, M., Ciciarelli, C., Di Stasio, E., Conte, G. L., Vulpio, C., Luciani, G., & Tazza, L. (2010). Correlates of symptoms of depression and anxiety in chronic hemodialysis patients. General Hospital Psychiatry, 32, 125131. doi:10.1016/j.genhosppsych.2009.10.009CrossRefGoogle ScholarPubMed
Bossola, M., Di Stasio, E., Giungi, S., Rosa, F., & Tazza, L. (2015). Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. Journal of Pain and Symptom Management, 49, 578585. doi:10.1016/j.jpainsymman.2014.07.009CrossRefGoogle ScholarPubMed
Boulware, L. E., Liu, Y., Fink, N. E., Coresh, J., Ford, D. E., Klag, M. J., & Powe, N. R. (2006). Temporal relation among depression symptoms, cardiovascular disease events, and mortality in end-stage renal disease: Contribution of reverse causality. Clinical Journal of the American Society of Nephrology, 1, 496504. doi:10.2215/cjn.00030505CrossRefGoogle ScholarPubMed
Bramer, W. M., Rethlefsen, M. L., Kleijnen, J., & Franco, O. H. (2017). Optimal database combinations for literature searches in systematic reviews: A prospective exploratory study. Systematic Reviews, 6, 245. doi:10.1186/s13643-017-0644-yCrossRefGoogle ScholarPubMed
Brys, A. D. H., Di Stasio, E., Lenaert, B., Sanguinetti, M., Picca, A., Calvani, R., … Bossola, M. (2020). Serum interleukin-6 and endotoxin levels and their relationship with fatigue and depressive symptoms in patients on chronic haemodialysis. Cytokine, 125, 154823. doi:https://doi.org/10.1016/j.cyto.2019.154823.CrossRefGoogle ScholarPubMed
Chilcot, J., Friedli, K., Guirguis, A., Wellsted, D., Farrington, K., & Davenport, A. (2017). C reactive protein and depressive symptoms in hemodialysis patients: A questionable association. Hemodialysis International, 21, 542548. doi:https://doi.org/10.1111/hdi.12500.CrossRefGoogle ScholarPubMed
Choi, M. J., Seo, J. W., Yoon, J. W., Lee, S. K., Kim, S. J., Lee, Y. K., … Koo, J. R. (2013). The malnutrition-inflammation-depression-arteriosclerosis complex is associated with an increased risk of cardiovascular disease and all-cause death in chronic hemodialysis patients. Nephron – Clinical Practice, 122, 4452.CrossRefGoogle Scholar
Cilan, H., Oguzhan, N., Unal, A., Turan, T., Koc, A. N., Sipahioglu, M. H., … Oymak, O. (2012). Relationship between depression and proinflammatory cytokine levels in hemodialysis patients. Renal Failure, 34, 275278. doi:10.3109/0886022x.2011.647292CrossRefGoogle ScholarPubMed
Cilan, H., Sipahioglu, M. H., Oguzhan, N., Unal, A., Turan, T., Koc, A. N., … Oymak, O. (2013). Association between depression, nutritional status, and inflammatory markers in peritoneal dialysis patients. Renal Failure, 35, 1722. doi: 10.3109/0886022X.2012.741643.CrossRefGoogle ScholarPubMed
Cobo, G., Lindholm, B., & Stenvinkel, P. (2018). Chronic inflammation in end-stage renal disease and dialysis. Nephrology Dialysis Transplantation, 33, 3540. doi:10.1093/ndt/gfy175CrossRefGoogle ScholarPubMed
Damayanti, I., Nasution, H. H., & Lubis, W. H. (2018). Correlation of depression symptoms and interleukin-6 in chronic renal disease with regular hemodialysis patients. Sumatera Medical Journal, 1, 1926. doi:10.32734/sumej.v1i1.442CrossRefGoogle Scholar
Dervisoglu, E., Kir, H. M., Kalender, B., Eraldemir, C., & Caglayan, C. (2008). Depressive symptoms and proinflammatory cytokine levels in chronic renal failure patients. Nephron – Clinical Practice, 108, 272277. doi:10.1159/000126907CrossRefGoogle ScholarPubMed
Dogan, E., Erkoc, R., Eryonucu, B., Sayarlioglu, H., & Agargun, M. Y. (2005). Relation between depression, some laboratory parameters, and quality of life in hemodialysis patients. Renal Failure, 27, 695699. doi:10.1080/08860220500242728CrossRefGoogle ScholarPubMed
Dong, J., Pi, H.-C., Xiong, Z.-Y., Liao, J.-L., Hao, L., Liu, G.-L., … Zheng, Z.-X. (2016). Depression and cognitive impairment in peritoneal dialysis: A multicenter cross-sectional study. American Journal of Kidney Diseases, 67(1), 111118. doi:10.1053/j.ajkd.2015.06.025CrossRefGoogle ScholarPubMed
Downes, M. J., Brennan, M. L., Williams, H. C., & Dean, R. S. (2016). Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS). British Medical Journal Open, 6, e011458. doi:10.1136/bmjopen-2016-011458Google ScholarPubMed
Ekrikpo, U. E., Kengne, A. P., Bello, A. K., Effa, E. E., Noubiap, J. J., Salako, B. L., … Okpechi, I. G. (2018). Chronic kidney disease in the global adult HIV-infected population: A systematic review and meta-analysis. PLoS ONE, 13, e0195443. doi:10.1371/journal.pone.0195443CrossRefGoogle ScholarPubMed
Fan, L., Sarnak, M. J., Tighiouart, H., Drew, D. A., Kantor, A. L., Lou, K. V., … Weiner, D. E. (2014). Depression and all-cause mortality in hemodialysis patients. American Journal of Nephrology, 40, 1218. doi:10.1159/000363539CrossRefGoogle ScholarPubMed
Farrokhi, F., Abedi, N., Beyene, J., Kurdyak, P., & Jassal, S. V. (2014). Association between depression and mortality in patients receiving long-term dialysis: A systematic review and meta-analysis. American Journal of Kidney Diseases, 63, 623635. doi:10.1053/j.ajkd.2013.08.024CrossRefGoogle ScholarPubMed
Fernandez-Rodriguez, C., Gonzalez-Fernandez, S., Coto-Lesmes, R., & Pedrosa, I. (2020). Behavioral activation and acceptance and commitment therapy in the treatment of anxiety and depression in cancer survivors: A randomized clinical trial. Behaviour Modification, 45, 822859. doi:10.1177/0145445520916441CrossRefGoogle ScholarPubMed
Foreman, K. J., Marquez, N., Dolgert, A., Fukutaki, K., Fullman, N., McGaughey, M., … Murray, C. J. L. (2018). Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: Reference and alternative scenarios for 2016–40 for 195 countries and territories. Lancet, 392, 20522090. doi:10.1016/s0140-6736(18)31694-5CrossRefGoogle ScholarPubMed
Gregg, L. P., Carmody, T., Le, D., Martins, G., Trivedi, M., & Hedayati, S. S. (2020). A systematic review and meta-analysis of depression and protein–energy wasting in kidney disease. Kidney International Reports, 5, 318330. doi:10.1016/j.ekir.2019.12.009CrossRefGoogle ScholarPubMed
Guenzani, D., Buoli, M., Caldiroli, L., Carnevali, G. S., Serati, M., Vezza, C., … Vettoretti, S. (2019). Malnutrition and inflammation are associated with severity of depressive and cognitive symptoms of old patients affected by chronic kidney disease. Journal of Psychosomatic Research, 124, 109783. doi:10.1016/j.jpsychores.2019.109783CrossRefGoogle ScholarPubMed
Guirguis, A., Chilcot, J., Almond, M., Davenport, A., Wellsted, D., & Farrington, K. (2020). Antidepressant usage in haemodialysis patients: Evidence of sub-optimal practice patterns. Journal of Renal Care, 46, 124132. doi:10.1111/jorc.12320CrossRefGoogle ScholarPubMed
Güney, İ., Biyik, M., Yeksan, M., Biyik, Z., Atalay, H., Solak, Y., … Türk, S. (2008). Sleep quality and depression in peritoneal dialysis patients. Renal Failure, 30, 10171022. doi:10.1080/08860220802406419CrossRefGoogle ScholarPubMed
Gyamlani, G., Basu, A., Geraci, S., Lee, F., Moxey, M., Clark, M., & Dubbert, P. M. (2011). Depression, screening and quality of life in chronic kidney disease. American Journal of the Medical Sciences, 342, 186191. doi:10.1097/MAJ.0b013e3182113d9eCrossRefGoogle ScholarPubMed
Harris, D. C. H., Davies, S. J., Finkelstein, F. O., Jha, V., Donner, J. A., Abraham, G., … Zuniga, C. (2019). Increasing access to integrated ESKD care as part of universal health coverage. Kidney International, 95, S1S33. doi:10.1016/j.kint.2018.12.005CrossRefGoogle Scholar
Haverkamp, G. L., Loosman, W. L., Schouten, R. W., Franssen, C. F., Kema, I. P., van Diepen, M., … Honig, A. (2018). Differences in the association of inflammation and tryptophan with depressive symptoms between white and non-white chronic dialysis patients. General Hospital Psychiatry, 50, 7682. doi:10.1016/j.genhosppsych.2017.10.003CrossRefGoogle Scholar
Haverkamp, G. L. G., Loosman, W. L., Schouten, R. W., Franssen, C. F. M., Kema, I. P., van Diepen, M., … Siegert, C. E. (2019). Longitudinal associations between inflammation and depressive symptoms in chronic dialysis patients. Psychosomatic Medicine, 81, 7480. doi:10.1097/psy.0000000000000649CrossRefGoogle ScholarPubMed
Hedayati, S. S., Gregg, L. P., Carmody, T., Jain, N., Toups, M., Rush, A. J., … Trivedi, M. H. (2017). Effect of sertraline on depressive symptoms in patients with chronic kidney disease without dialysis dependence: The CAST randomized clinical trial. Journal of the American Medical Association, 318, 18761890. doi:10.1001/jama.2017.17131CrossRefGoogle ScholarPubMed
Higgins, J. P., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (2019). Cochrane handbook for systematic reviews of interventions (2nd ed.). UK: John Wiley & Sons.CrossRefGoogle Scholar
Hsu, H. J., Chen, C. K., Hsiao, C. C., Wu, I. W., Sun, C. Y., Chou, C. C., … Wu, M. S. (2009a). Lack of association between plasma dehydroepiandrosterone sulfate (DHEA-S) levels and depression in hemodialysis patients: A cross-sectional study. Experimental Gerontology, 44, 733739. doi:10.1016/j.exger.2009.08.009CrossRefGoogle ScholarPubMed
Hsu, H. J., Chen, C. K., & Wu, M. S. (2009b). Lower prevalence of depression in hemodialysis patients who use polysulfone dialyzers. American Journal of Nephrology, 29, 592597. doi:10.1159/000193144CrossRefGoogle ScholarPubMed
Hung, K. C., Wu, C. C., Chen, H. S., Ma, W. Y., Tseng, C. F., Yang, L. K., … Lu, K. C. (2011). Serum IL-6, albumin and co-morbidities are closely correlated with symptoms of depression in patients on maintenance haemodialysis. Nephrology Dialysis Transplantation, 26, 658664. doi:10.1093/ndt/gfq411CrossRefGoogle ScholarPubMed
Iida, H., Fujimoto, S., Wakita, T., Yanagi, M., Suzuki, T., Koitabashi, K., … Kurita, N. (2020). Psychological flexibility and depression in advanced CKD and dialysis. Kidney Medicine, 2, 684691 e681. doi:10.1016/j.xkme.2020.07.004CrossRefGoogle ScholarPubMed
Jong, I.-C., Tsai, H.-B., Lin, C.-H., Ma, T.-L., Guo, H.-R., Hung, P.-H., & Hung, K.-Y. (2017). Close correlation between the ankle-brachial index and symptoms of depression in hemodialysis patients. International Urology and Nephrology, 49, 14631470. doi:10.1007/s11255-017-1598-7CrossRefGoogle ScholarPubMed
Kalender, B., Dervisoglu, E., Sengul, E., Ozdemir, A. C., Akhan, S. C., Yalug, I., & Uzun, H. (2007). Depression, nutritional status, and serum cytokines in peritoneal dialysis patients: Is there a relationship? Peritoneal Dialysis International, 27, 593595. Retrieved from https://pubmed.ncbi.nlm.nih.gov/17704454/.CrossRefGoogle ScholarPubMed
Kalender, B., Ozdemir, A. C., & Koroglu, G. (2006). Association of depression with markers of nutrition and inflammation in chronic kidney disease and end-stage renal disease. Nephron – Clinical Practice, 102, 115121. doi:10.1159/000089669CrossRefGoogle ScholarPubMed
Khandaker, G. M., Zuber, V., Rees, J. M. B., Carvalho, L., Mason, A. M., Foley, C. N., … Burgess, S. (2019). Shared mechanisms between coronary heart disease and depression: Findings from a large UK general population-based cohort. Molecular Psychiatry, 25, 14771486. doi:10.1038/s41380-019-0395-3CrossRefGoogle ScholarPubMed
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015). Inflammation: Depression fans the flames and feasts on the heat. American Journal of Psychiatry, 172, 10751091. doi:10.1176/appi.ajp.2015.15020152CrossRefGoogle ScholarPubMed
Kim, J. K., Kim, S. G., Kim, H. J., & Song, Y. R. (2012). Serum S100B protein is associated with depressive symptoms in patients with end-stage renal disease. Clinical Biochemistry, 45, 15731577. doi:10.1016/j.clinbiochem.2012.08.014CrossRefGoogle ScholarPubMed
Knuth, B., Radtke, V., Rocha, P., da Silva, K. S., Dalsóglio, F., Gazal, M., … Oses, J. P. (2014). Prevalence of depression symptoms and serum levels of interleukin-6 in hemodialysis patients. Psychiatry and Clinical Neurosciences, 68, 275282. doi:10.1111/pcn.12130CrossRefGoogle ScholarPubMed
Ko, G. J., Kim, M. G., Yu, Y. M., Jo, S. K., Cho, W. Y., & Kim, H. K. (2010). Association between depression symptoms with inflammation and cardiovascular risk factors in patients undergoing peritoneal dialysis. Nephron – Clinical Practice, 116, c29c35. doi:10.1159/000314548CrossRefGoogle ScholarPubMed
Kusztal, M., Trafidło, E., Madziarska, K., Augustyniak-Bartosik, H., Karczewski, M., Weyde, W., … Klinger, M. (2018). Depressive symptoms but not chronic pain have an impact on the survival of patients undergoing maintenance hemodialysis. Archives of Medical Science, 14, 265275. doi:10.5114/aoms.2016.59765CrossRefGoogle Scholar
Lee, S., Lee, K. H., Park, K. M., Park, S. J., Kim, W. J., Lee, J., … Fusar-Poli, P. (2021). Impact of data extraction errors in meta-analyses on the association between depression and peripheral inflammatory biomarkers: An umbrella review. Psychological Medicine, 9, 114. doi:10.1017/S0033291721003767.Google Scholar
Levey, A. S., Eckardt, K. U., Dorman, N. M., Christiansen, S. L., Hoorn, E. J., Ingelfinger, J. R., … Winkelmayer, W. C. (2020). Nomenclature for kidney function and disease: Report of a kidney disease: Improving global outcomes (KDIGO) consensus conference. Kidney International, 97, 11171129. doi:10.1016/j.kint.2020.02.010CrossRefGoogle ScholarPubMed
Li, Z. J., An, X., Mao, H. P., Wei, X., Chen, J. H., Yang, X., … Yu, X. Q. (2011). Association between depression and malnutrition-inflammation complex syndrome in patients with continuous ambulatory peritoneal dialysis. International Urology and Nephrology, 43, 875882. doi:10.1007/s11255-011-9917-xCrossRefGoogle ScholarPubMed
Liyanage, T., Ninomiya, T., Jha, V., Neal, B., Patrice, H. M., Okpechi, I., … Perkovic, V. (2015). Worldwide access to treatment for end-stage kidney disease: A systematic review. Lancet, 385, 19751982. doi:10.1016/s0140-6736(14)61601-9CrossRefGoogle ScholarPubMed
Lunyera, J., Mohottige, D., Von Isenburg, M., Jeuland, M., Patel, U. D., & Stanifer, J. W. (2016). CKD Of uncertain etiology: A systematic review. Clinical Journal of the American Society of Nephrology, 11, 379385. doi:10.2215/cjn.07500715CrossRefGoogle ScholarPubMed
Malhotra, R., Persic, V., Zhang, W., Brown, J., Tao, X., Rosales, L., … Kotanko, P. (2017). Tryptophan and kynurenine levels and its association with sleep, nonphysical fatigue, and depression in chronic hemodialysis patients. Journal of Renal Nutrition, 27, 260266. doi:10.1053/j.jrn.2017.01.024CrossRefGoogle ScholarPubMed
Micozkadioglu, H., Micozkadioglu, I., Zumrutdal, A., Erdem, A., Ozdemir, F. N., Sezer, S., & Haberal, M. (2006). Relationship between depressive affect and malnutrition-inflammation complex syndrome in haemodialysis patients. Nephrology, 11, 502505. doi:10.1111/j.1440-1797.2006.00664.xCrossRefGoogle ScholarPubMed
Miller, A. H., & Raison, C. L. (2016). The role of inflammation in depression: From evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16, 2234. doi:10.1038/nri.2015.5CrossRefGoogle Scholar
Mok, M. M. Y., Liu, C. K. M., Lam, M. F., Kwan, L. P. Y., Chan, G. C. W., Ma, M. K. M., … Chan, T. M. (2019). A longitudinal study on the prevalence and risk factors for depression and anxiety, quality of life, and clinical outcomes in incident peritoneal dialysis patients. Peritoneal Dialysis International, 39, 7482. doi:10.3747/pdi.2017.00168CrossRefGoogle ScholarPubMed
Morgan, R. L., Whaley, P., Thayer, K. A., & Schünemann, H. J. (2018). Identifying the PECO: A framework for formulating good questions to explore the association of environmental and other exposures with health outcomes. Environment International, 121, 10271031. doi:10.1016/j.envint.2018.07.015CrossRefGoogle Scholar
Mosleh, H., Alenezi, M., Al Johani, S., Alsani, A., Fairaq, G., & Bedaiwi, R. (2020). Prevalence and factors of anxiety and depression in chronic kidney disease patients undergoing hemodialysis: A cross-sectional single-center study in Saudi Arabia. Cureus Journal of Medical Science, 12, e6668. doi:10.7759/cureus.6668Google ScholarPubMed
Nie, X. D., Wang, Q., Zhang, Y. H., Xiong, Z. Y., Liao, J. L., Hao, L., … Dong, J. (2019). Depression at baseline is an independent risk factor for cognitive decline in patients on peritoneal dialysis: A multicenter prospective cohort study. Peritoneal Dialysis International, 39, 465471. doi:10.3747/pdi.2018.00239CrossRefGoogle ScholarPubMed
Nikkheslat, N., Zunszain, P. A., Horowitz, M. A., Barbosa, I. G., Parker, J. A., Myint, A. M., … Pariante, C. M. (2015). Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Brain, Behavior, and Immunity, 48, 818. doi:10.1016/j.bbi.2015.02.002CrossRefGoogle ScholarPubMed
Nowak, Ł., Adamczak, M., & Więcek, A. (2013). Is inflammation a new risk factor of depression in haemodialysis patients? International Urology and Nephrology, 45, 11211128. doi:10.1007/s11255-012-0269-yCrossRefGoogle ScholarPubMed
Oguz, E. G., Akoglu, H., Ulusal Okyay, G., Yayar, O., Karaveli Gursoy, G., Buyukbakkal, M., … Ayli, M. D. (2016). Serum apelin is associated with affective disorders in peritoneal dialysis patients. Renal Failure, 38, 10591066. doi:10.1080/0886022x.2016.1193873CrossRefGoogle Scholar
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan – A web and mobile app for systematic reviews. Systematic Reviews, 5, 210. doi:10.1186/s13643-016-0384-4CrossRefGoogle Scholar
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Systematic Reviews, 10, 89. doi:10.1186/s13643-021-01626-4CrossRefGoogle ScholarPubMed
Palmer, S. C., Vecchio, M., Craig, J. C., Tonelli, M., Johnson, D. W., Nicolucci, A., … Strippoli, G. F. (2013). Association between depression and death in people with CKD: A meta-analysis of cohort studies. American Journal of Kidney Diseases, 62, 493505. doi:10.1053/j.ajkd.2013.02.369CrossRefGoogle ScholarPubMed
Park, H. C., Lee, H., Lee, J. P., Kim, D. K., Oh, K. H., Joo, K. W., … Oh, Y. K. (2012). Lower residual renal function is a risk factor for depression and impaired health-related quality of life in Korean peritoneal dialysis patients. Journal of Korean Medical Science, 27, 6471. doi:10.3346/jkms.2012.27.1.64CrossRefGoogle ScholarPubMed
Park, H. C., Yoon, H. B., Son, M. J., Jung, E. S., Joo, K. W., Chin, H. J., … Oh, Y. K. (2010). Depression and health-related quality of life in maintenance hemodialysis patients. Clinical Nephrology, 73, 374380. doi:10.5414/cnp73374CrossRefGoogle ScholarPubMed
Rapa, S. F., Di Iorio, B. R., Campiglia, P., Heidland, A., & Marzocco, S. (2019). Inflammation and oxidative stress in chronic kidney disease-potential therapeutic role of minerals, vitamins and plant-derived metabolites. International Journal of Molecular Sciences, 21, 263. doi:10.3390/ijms21010263CrossRefGoogle ScholarPubMed
Rosenthal Asher, D., Ver Halen, N., & Cukor, D. (2012). Depression and nonadherence predict mortality in hemodialysis treated end-stage renal disease patients. Hemodialysis International, 16, 387393. doi:10.1111/j.1542-4758.2012.00688.xCrossRefGoogle ScholarPubMed
Ryan, R. (2016). Cochrane consumers and communication group: Meta-analysis. Retrieved from http://cccrg.cochrane.org.Google Scholar
Salazar, J. J., Ennis, W. J., & Koh, T. J. (2016). Diabetes medications: Impact on inflammation and wound healing. Journal of Diabetes and its Complications, 30, 746752. doi:10.1016/j.jdiacomp.2015.12.017CrossRefGoogle ScholarPubMed
Schricker, S., Heider, T., Schanz, M., Dippon, J., Alscher, M. D., Weiss, H., … Kimmel, M. (2019). Strong associations between inflammation, pruritus and mental health in dialysis patients. Acta Dermato-Venereologica, 99, 524529. doi:10.2340/00015555-3128CrossRefGoogle ScholarPubMed
Silva, I. V., de Figueiredo, R. C., & Rios, D. R. (2019). Effect of different classes of antihypertensive drugs on endothelial function and inflammation. International Journal of Molecular Sciences, 20(14), 3458. doi:10.3390/ijms20143458.CrossRefGoogle ScholarPubMed
Simic Ogrizovic, S., Jovanovic, D., Dopsaj, V., Radovic, M., Sumarac, Z., Bogavac, S. N., … Nesic, V. (2009). Could depression be a new branch of MIA syndrome? Clinical Nephrology, 71, 164172. doi:10.5414/cnp71164CrossRefGoogle ScholarPubMed
Simone Jayakumar, K. B., Bhui, K., Schofield, J., Ronaldson, A., Yaqoob, M., & Carvalho, L. (2019). The association between depression and inflammation in patients with chronic kidney disease (CKD) or end stage renal disease (ESRD): a systematic review of the literature. Retrieved from https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019141305.Google Scholar
Sonikian, M., Metaxaki, P., Papavasileiou, D., Boufidou, F., Nikolaou, C., Vlassopoulos, D., & Vlahakos, D. V. (2010). Effects of interleukin-6 on depression risk in dialysis patients. American Journal of Nephrology, 31, 303308. doi:10.1159/000285110CrossRefGoogle ScholarPubMed
Sterne, J. A., Hernán, M. A., Reeves, B. C., Savović, J., Berkman, N. D., Viswanathan, M., … Higgins, J. P. (2016). ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. British Medical Journal, 355, i4919. doi:10.1136/bmj.i4919CrossRefGoogle ScholarPubMed
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., … Higgins, J. P. T. (2019). RoB 2: A revised tool for assessing risk of bias in randomised trials. British Medical Journal, 366, l4898. doi:10.1136/bmj.l4898CrossRefGoogle ScholarPubMed
Su, S. F., Ng, H. Y., Huang, T. L., Chi, P. J., Lee, Y. T., Lai, C. R., … Lee, C. T. (2012). Survey of depression by Beck Depression Inventory in uremic patients undergoing hemodialysis and hemodiafiltration. Therapeutic Apheresis and Dialysis, 16, 573579. doi:10.1111/j.1744-9987.2012.01094.xCrossRefGoogle ScholarPubMed
Taraz, M., Khatami, M. R., Dashti-Khavidaki, S., Akhonzadeh, S., Noorbala, A. A., Ghaeli, P., & Taraz, S. (2013). Sertraline decreases serum level of interleukin-6 (IL-6) in hemodialysis patients with depression: Results of a randomized double-blind, placebo-controlled clinical trial. International Immunopharmacology, 17, 917923. doi:10.1016/j.intimp.2013.09.020CrossRefGoogle ScholarPubMed
Taraz, M., Khatami, M. R., Gharekhani, A., Abdollahi, A., Khalili, H., & Dashti-Khavidaki, S. (2012). Relationship between a pro- and anti-inflammatory cytokine imbalance and depression in haemodialysis patients. European Cytokine Network, 23, 179186. doi:10.1684/ecn.2013.0326Google ScholarPubMed
Tufan, F., Yıldız, A., Dogan, I., Yıldız, D., & Sevinir, Ş. (2015). Urea to creatinine ratio: A forgotten marker of poor nutritional state in patients undergoing hemodialysis treatment. The Aging Male, 18, 4953. doi:10.3109/13685538.2014.908281CrossRefGoogle ScholarPubMed
Uglešić, B., Ljutić, D., Lasić, D., Jeličić, I., Višić, V., Glavina, T., … Meter, A. (2015). Depression and serum interleukin-6 levels in patients on dialysis. Psychiatria Danubina, 27, 168173.Google ScholarPubMed
Wan, X., Wang, W., Liu, J., & Tong, T. (2014). Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. British Medical Council Medical Research Methodology, 14, 135. doi:10.1186/1471-2288-14-135Google ScholarPubMed
Wang, L. J., Wu, M. S., Hsu, H. J., Wu, I. W., Sun, C. Y., Chou, C. C., … Chen, C. K. (2012). The relationship between psychological factors, inflammation, and nutrition in patients with chronic renal failure undergoing hemodialysis. The International Journal of Psychiatry in Medicine, 44, 105118. doi:10.2190/PM.44.2.bCrossRefGoogle ScholarPubMed
Wang, Y., Liu, Y., Lian, Y., Li, N., Liu, H., & Li, G. (2016). Efficacy of high-dose supplementation with oral vitamin D3 on depressive symptoms in dialysis patients with vitamin D3 insufficiency: A prospective, randomized, double-blind study. Journal of Clinical Psychopharmacology, 36, 229235. doi:10.1097/jcp.0000000000000486CrossRefGoogle ScholarPubMed
Webster, A. C., Nagler, E. V., Morton, R. L., & Masson, P. (2017). Chronic kidney disease. Lancet (London, England), 389, 12381252. doi:10.1016/s0140-6736(16)32064-5CrossRefGoogle ScholarPubMed
Wells, G., Shea, B., O Connell, D. L., Peterson, J., Welch, V., Losos, M., … Petersen, J. (2014). The Newcastle–Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Retrieved from https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.Google Scholar
Wilson, D. B. (2001). Practical meta-analysis effect size calculator. Retrieved from https://campbellcollaboration.org/escalc/html/EffectSizeCalculator-Home.php.Google Scholar
Yavuz, R., Yavuz, D., Altunoglu, A., Canoz, M. B., Sezer, S., Yalcin, B. M., & Demirag, M. D. (2015). Depression, inflammation, and social support in hemodialysis patients. Journal of Clinical and Analytical Medicine, 6, 801805. doi:10.4328/JCAM.3679Google Scholar
Zalli, A., Jovanova, O., Hoogendijk, W. J., Tiemeier, H., & Carvalho, L. A. (2016). Low-grade inflammation predicts persistence of depressive symptoms. Psychopharmacology, 233, 16691678. doi:10.1007/s00213-015-3919-9CrossRefGoogle ScholarPubMed
Zhang, J., Zhang, P., Ni, X., Bao, B., Huang, C., Wu, Y., … Chen, J. (2014). Vitamin D status in chronic dialysis patients with depression: A prospective study. British Medical Council Psychiatry, 14, 125. doi:10.1186/1471-244X-14-125Google ScholarPubMed
Zhao, C., Ma, H., Yang, L., & Xiao, Y. (2017). Long-term bicycle riding ameliorates the depression of the patients undergoing hemodialysis by affecting the levels of interleukin-6 and interleukin-18. Neuropsychiatric Disease and Treatment, 13, 91100. doi:10.2147/ndt.S124630CrossRefGoogle Scholar
Supplementary material: File

Jayakumar et al. supplementary material

Jayakumar et al. supplementary material

Download Jayakumar et al. supplementary material(File)
File 110.3 KB