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Stereotypy, schizophrenia and dopamine D2 receptor binding in the basal ganglia

Published online by Cambridge University Press:  09 July 2009

B. M. Pedro ,
L. S. Pilowsky ,
D. C. Costa ,
D. R. Hemsley ,
P. J. Ell ,
N. P. L. G. Verhoeff ,
R. W. Kerwin  and
N. S. Gray
B. M. Pedro*
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
L. S. Pilowsky
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
D. C. Costa
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
D. R. Hemsley
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
P. J. Ell
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
N. P. L. G. Verhoeff
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
R. W. Kerwin
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
N. S. Gray
Affiliation:
Departments of Psychology and Psychological Medicine, Institute of Psychiatry, and Institute of Nuclear Medicine and UCSM, Middlesex Hospital, London; Cygne b.v. and Amsterdam Medical Centre, The Netherlands
*
1 Address for correspondence: Dr B. M. Pedro, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
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Synopsis

Animal models suggest a relationship between disturbed striatal dopaminergic function and stereotyped behaviour. Several studies show increased stereotypy in schizophrenic patients compared to normal controls. We investigated the performance of 12 antipsychotic-drug-free schizophrenic patients, and 15 healthy control subjects on a neuropsychological measure of stereotypy – the two-choice guessing task – and correlated this with in vivo striatal dopamine D2 receptor binding, as measured by 123I-iodobenzamide single photon emission tomography. Patients and controls did not differ with respect to the measures of stereotypy derived from the task. However, there was a significant correlation between one of these measures (RR Information) and the degree of striatal D2 receptor binding asymmetry in the patient group only. In view of research connecting striatal and frontal lesions with stereotypy in animals and cognitive inflexibility in humans, these data could suggest a similar disturbance underlying the phenomenon in schizophrenia.

Type
Original Articles
Information
Psychological Medicine , Volume 24 , Issue 2 , May 1994 , pp. 423 - 429
Copyright
Copyright © Cambridge University Press 1994

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