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Sampling strategy in linkage studies of affective disorders

Published online by Cambridge University Press:  09 July 2009

M. Leboyer ,
M. C. Babron  and
F. Clerget-Darpoux
M. Leboyer*
Affiliation:
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
M. C. Babron
Affiliation:
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
F. Clerget-Darpoux
Affiliation:
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
*
1Address for correspondence: Dr M. Leboyer, INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Château de Longchamp, Bois de Boulogne, Paris 75016, France.
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Synopsis

Evidence of linkage in families of bipolar patients has so far been identified with genetic markers on chromosome X and 11. However, replications of these data have not consistently been reported in either case, which favours the hypothesis of genetic heterogeneity. Therefore, we have tried to outline a sampling strategy for linkage replication in affective disorders. We estimated the average number of nuclear families required to replicate X or 11 linkage as a function of the degree of heterogeneity as well as the number to prove heterogeneity given that linkage exists. The results are presented and discussed.

Type
Original Articles
Information
Psychological Medicine , Volume 20 , Issue 3 , August 1990 , pp. 573 - 579
Copyright
Copyright © Cambridge University Press 1990

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