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Pre-morbid asociality in neuroleptic-resistant and neuroleptic-responsive schizophrenia

Published online by Cambridge University Press:  09 July 2009

R. L. Findling ,
K. Jayathilake  and
H. Y. Meltzer
R. L. Findling
Affiliation:
Department of Psychiatry, Laboratory of Biological Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
K. Jayathilake
Affiliation:
Department of Psychiatry, Laboratory of Biological Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
H. Y. Meltzer*
Affiliation:
Department of Psychiatry, Laboratory of Biological Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
*
1Address for correspondence: Professor Herbert Y. Meltzer Department of PsychiatryUniversity Hospitals of ClevelandHanna PavilionRoom B-6811100 Euclid AvenueClevelandOH 44106–5078USA.
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Synopsis

The purpose of this study was to evaluate whether childhood and adolescent premorbid asociality differed in neuroleptic-responsive and neuroleptic-resistant schizophrenia. Premorbid asociality was assessed with the Pre-morbid Asociality Adjustment Scale in 411 patients meeting DSM-III-R criteria for chronic schizophrenia or schizoaffective disorder categorized as being either neuroleptic-responsive or neuroleptic-resistant. Patterns of childhood and adolescent asociality were found to be different in neuroleptic-resistant and neuroleptic-responsive patients. Pre-morbid asociality during the pre-adult years was not consistently worse in patients with poor response to neuroleptic treatment. Greater impairment in late adolescent psychosexual functioning was predictive of poor outcome with regard to neuroleptic treatment.

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 5 , September 1996 , pp. 1033 - 1041
Copyright
Copyright © Cambridge University Press 1996

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References

Bardenstein, K. K. & McGlashan, T. H. (1990). Gender differences in affective, schizoaffective and schizophrenic disorders: Schizophrenia Research 3, 159–172.CrossRefGoogle ScholarPubMed
Bartkó, G., Frecska, E., Horvath, S., Zador, G. & Arato, M. (1990). Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients. Acta Psychiatrica Scandinavica 82, 408–412.CrossRefGoogle ScholarPubMed
Brenner, H. D., Dencker, S. J., Goldstein, M. J., Hubbard, J. W., Keegen, D. L., Kruger, G., Kulhanek, F., Liberman, R. P., Malm, U. & Midha, K. K. (1990). Defining treatment refractoriness in schizophrenia. Schizophrenia Bulletin 16, 551–562.Google Scholar
Brown, W. A. & Herz, L. R. (1989). Response to neuroleptic drugs as a device for classifying schizophrenia. Schizophrenia Bulletin 25, 123–129.CrossRefGoogle Scholar
Cannon-Spoor, H. E., Potkin, S. G. & Wyatt, R. J. (1982). Measurement of premorbid adjustment in chronic schizophrenia. Schizophrenia Bulletin 8, 470–484.CrossRefGoogle ScholarPubMed
Castle, D. J. & Murray, R. M. (1991). The neurodevelopmental basis of sex differences in schizophrenia. Psychological Medicine 21, 565–575.CrossRefGoogle ScholarPubMed
Castle, D. J., Wessely, S. & Murray, R. M. (1993). Sex and schizophrenia: effects of diagnostic stringency, and associations with premorbid variables. British Journal of Psychiatry 162, 685–664.CrossRefGoogle ScholarPubMed
Crow, T. J. (1980). Molecular pathology of schizophrenia: more than one disease process? British Medical Journal 280, 66–68.Google Scholar
Davis, J. M., Schaffer, C. B., Killian, G. A., Kinard, C. & Chan, C. (1980). Important issues in the drug treatment of schizophrenia. Schizophrenia Bulletin 6, 70–87.Google Scholar
DeLisi, L. E., Dauphinais, I. D. & Hauser, P. (1989). Gender differences in the brain: are they relevant to the pathogenesis in schizophrenia? Comprehensive Psychiatry 30, 207–208.CrossRefGoogle Scholar
Done, D. J., Crow, T. J., Johnstone, E. C. & Sacker, A. (1994). Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. British Medical Journal 309, 699–703.Google Scholar
Endicott, J. & Spitzer, R. L. (1978). A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry 35, 837–844.CrossRefGoogle ScholarPubMed
Findling, R. L., Weishampel, P., Cola, P. A., Jayathilake, K. & Meltzer, H. Y. (1996). Childhood and adolescent psychosocial functioning in neuroleptic-resistant and neuroleptic-responsive adults with schizophrenia. (Submitted.)Google Scholar
Garmezy, M. (1968). Process and reactive schizophrenia: Some conceptions and issues. In The Role and Methodology of Classification in Psychiatry and Psychopathology (ed Katz, M. M., Cole, J. O. and Barton, W. E.) pp. 419–466. Superintendent of Documents. US Government Printing Office: Washington, DC.Google Scholar
Garmezy, N., with the collaboration of Streitman S. (1974). Children at risk: the search for the antecedents of schizophrenia. Part I: Conceptual models and research methods. Schizophrenia Bulletin 1 (Experimental Issue No. 8), 14–90.Google Scholar
Gittleman-Klein, R. & Klein, D. F. (1969). Premorbid asocial adjustment and prognosis in schizophrenia. Journal of Psychiatry Research 7, 35–53.CrossRefGoogle Scholar
Goldstein, J. M. (1988). Gender differences in the course of schizophrenia. American Journal of Psychiatry 145, 684–689.Google ScholarPubMed
Haas, G. & Sweeney, J. (1992). Premorbid and onset features of first episode schizophrenia. Schizophrenia Bulletin 18, 373–386.CrossRefGoogle ScholarPubMed
Häfner, H., Riecher-Rössler, A., An Der Heisen, W., Maurer, K., Fatkenheuer, B. & Loffler, W. (1993). Generating and testing a causal explanation of the gender difference in age at first onset of schizophrenia. Psychological Medicine 23, 925–940.Google Scholar
Isele, R., Merz, J., Malzacher, M. & Angst, J. (1985). Social disability in schizophrenia: the controlled prospective Burghozli study. II. Premorbid living situation and social adjustment-comparison with a normal control sample. European Archives of Psychiatry and Neurological Sciences 234, 348–356.CrossRefGoogle Scholar
Kane, J., Honigfeld, G., Singer, J., Meltzer, H. Y. & the Clozaril Collaborative Study Group (1988). Clozapine for the treatment-resistant schizophrenic. Archives of General Psychiatry 45, 789–796.Google Scholar
Keefe, R. S. E., Mohs, R., Losonczy, M. F., Davidson, M., Silverman, J. M., Horvath, T. & Davis, K. L. (1989). Premorbid sociosexual functioning and long-term outcome in schizophrenia. American Journal of Psychiatry 146, 206–211.Google Scholar
Klein, D. F., Rosen, B. & Oaks, G. (1973). Premorbid asocial adjustment and response to phenothiazine treatment among schizophrenic inpatients. Arch Gen Psychiatry 29, 480–485.Google Scholar
Kolakowska, T., Williams, A. O., Reveley, M. A. & Ardern, M. (1985). Schizophrenia with good and poor outcome I: early clinical features, response to neuroleptics and signs of organic dysfunction. British Journal of Psychiatry 146, 229–246.Google Scholar
Lieberman, J. A. & Koreen, A. F. (1993). Neurochemistry and neuroendocrinology of schizophrenia: a selective review. Schizophrenia Bulletin 19, 371–429.Google Scholar
Meltzer, H. Y. (1991). The mechanism of action of novel antipsychotic drugs. Schizophrenia Bulletin, 17, 263–287.Google Scholar
Meltzer, H. Y., Rabinowitz, J., Lee, M. A., Thompson, P. A., Ranjan, R. & Findling, R. (1996). Age at onset and gender of schizophrenia in relation to neuroleptic-resistance. American Journal of Psychiatry (in the press).Google Scholar
Seeman, M. V. (1986). Current outcome in schizophrenia: women vs. men. Acta Psychiatrica Scandinavica 73, 609–617.Google Scholar
Wolkin, A., Barouche, F., Wolf, A. P., Rotrosen, J., Fowler, J. S., Shiue, C.-Y., Cooper, T. B. & Brodie, J. D. (1989). Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia. American Journal of Psychiatry 146, 905–908.Google Scholar