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Microstructural abnormalities of white matter in the cingulum bundle of adolescents with major depression and non-suicidal self-injury

Published online by Cambridge University Press:  03 November 2023

Changchun Hu ,
Wenhao Jiang ,
Yun Wu ,
Mei Wang ,
Jian Lin ,
Suzhen Chen ,
Yushan Shang ,
Jian Xie ,
Youyong Kong  and
Yonggui Yuan Open the ORCID record for Yonggui Yuan [Opens in a new window]
Changchun Hu
Affiliation:
Department of Psychosomatics and Psychiatry, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, China Department of Clinical Psychology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Wenhao Jiang
Affiliation:
Department of Psychosomatics and Psychiatry, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, China
Yun Wu
Affiliation:
Department of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Mei Wang
Affiliation:
Department of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jian Lin
Affiliation:
Department of Clinical Psychology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Suzhen Chen
Affiliation:
Department of Psychosomatics and Psychiatry, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, China
Yushan Shang
Affiliation:
Department of Clinical Psychology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jian Xie*
Affiliation:
Department of Clinical Psychology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Youyong Kong*
Affiliation:
Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, Jiangsu, China
Yonggui Yuan*
Affiliation:
Department of Psychosomatics and Psychiatry, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, China
*
Corresponding authors: Jian Xie; Email: hccxlyz@163.com; Youyong Kong; Email: kongyouyong@seu.edu.cn; Yonggui Yuan; Email: yygylh2000@sina.com
Corresponding authors: Jian Xie; Email: hccxlyz@163.com; Youyong Kong; Email: kongyouyong@seu.edu.cn; Yonggui Yuan; Email: yygylh2000@sina.com
Corresponding authors: Jian Xie; Email: hccxlyz@163.com; Youyong Kong; Email: kongyouyong@seu.edu.cn; Yonggui Yuan; Email: yygylh2000@sina.com
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Abstract

Background

Non-suicidal self-injury (NSSI) is prevalent in major depressive disorder (MDD) during adolescence, but the underlying neural mechanisms are unclear. This study aimed to investigate microstructural abnormalities in the cingulum bundle associated with NSSI and its clinical characteristics.

Methods

130 individuals completed the study, including 35 healthy controls, 47 MDD patients with NSSI, and 48 MDD patients without NSSI. We used tract-based spatial statistics (TBSS) with a region of interest (ROI) analysis to compare the fractional anisotropy (FA) of the cingulum bundle across the three groups. receiver-operating characteristics (ROC) analysis was employed to evaluate the ability of the difficulties with emotion regulation (DERS) score and mean FA of the cingulum to differentiate between the groups.

Results

MDD patients with NSSI showed reduced cingulum integrity in the left dorsal cingulum compared to MDD patients without NSSI and healthy controls. The severity of NSSI was negatively associated with cingulum integrity (r = −0.344, p = 0.005). Combining cingulum integrity and DERS scores allowed for successful differentiation between MDD patients with and without NSSI, achieving a sensitivity of 70% and specificity of 83%.

Conclusions

Our study highlights the role of the cingulum bundle in the development of NSSI in adolescents with MDD. The findings support a frontolimbic theory of emotion regulation and suggest that cingulum integrity and DERS scores may serve as potential early diagnostic tools for identifying MDD patients with NSSI.

Keywords

cingulum bundledifficulties with emotion regulationdiffusion tensor imagingmajor depressive disordernon-suicidal self-injury (NSSI)
Type
Original Article
Information
Psychological Medicine , Volume 54 , Issue 6 , April 2024 , pp. 1113 - 1121
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

*

These authors are co-first authors of this work.

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