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Methysergide in mania: a double-blind comparison with thioridazine

Published online by Cambridge University Press:  09 July 2009

H. B. McNamee ,
D. Le Poidevin  and
G. J. Naylor
H. B. McNamee
Affiliation:
Department of Psychiatry, University of Dundee, and Royal Dundee Liff Hospital
D. Le Poidevin
Affiliation:
Department of Psychiatry, University of Dundee, and Royal Dundee Liff Hospital
G. J. Naylor
Affiliation:
Department of Psychiatry, University of Dundee, and Royal Dundee Liff Hospital
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Synopsis

During 20 separate illnesses 17 severely disturbed manic patients were given either methysergide or thioridazine in a 21 day double-blind controlled trial. For most of the trial patients received either 9 mg methysergide or 450 mg thioridazine daily; during one 24-hour period 12 mg methysergide or 600 mg thioridazine was administered. Daily clinical assessments were made. Methysergide proved significantly less effective than the phenothiazine.

Type
Research Article
Information
Psychological Medicine , Volume 2 , Issue 1 , February 1972 , pp. 66 - 69
Copyright
Copyright © Cambridge University Press 1972

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References

REFERENCES

Batchelor, I. R. C. (ed.) (1969). Affective reaction-types. Manic-depressive psychosis. Henderson and Gillespie's Textbook of Psychiatry. 10th Edition. Chapter 10, pp. 210–246. Oxford University Press: London.Google Scholar
Coppen, A., Prange, A. J. Jr, Whybrow, P. C., Noguera, R., and Paez, J. M. (1969). Methysergide in mania. A controlled trial. Lancet, 2, 338–340.Google Scholar
Dewhurst, W. G. (1965). On the chemical basis of mood. Journal of Psychosomatic Research, 9, 115–127.CrossRefGoogle ScholarPubMed
Dewhurst, W. G. (1968). Methysergide in mania. Nature, 219, 506–507.CrossRefGoogle ScholarPubMed
Dewhurst, W. G. (1969a). Methysergide in mania. Lancet, 1, 624–625.CrossRefGoogle ScholarPubMed
Dewhurst, W. G. (1969b). Methysergide in mania. Lancet 2, 490.Google Scholar
Fieve, R. R., Platman, S. R., and Fleiss, J. L. (1969). A clinical trial of methysergide and lithium in mania. Psychopharmacologia, 15, 425–429.CrossRefGoogle ScholarPubMed
Greenspan, K., Schildkraut, J. J., Gordon, E. K., Levy, B., and Durell, J. (1969). Catecholamine metabolism in affective disorders. Archives of General Psychiatry, 21, 710–716.CrossRefGoogle ScholarPubMed
Grof, P., and Foley, P. (1971). The superiority of lithium over methysergide in treating manic patients. American Journal of Psychiatry, 127, 1573–1574.CrossRefGoogle ScholarPubMed
Haškovec, L. (1969). Methysergide in mania. Lancet, 2, 902.Google Scholar
Haškovec, L., and Souček, K. (1969). The action of methysergide in manic states. Psychopharmacologia, 15, 415–424.Google Scholar
McCabe, M. S., Reich, T., and Winokur, G. (1970). Methy-sergide as a treatment for mania. American Journal of Psychiatry, 127, 354–356.CrossRefGoogle Scholar
Serry, D. (1969). Methysergide in mania. Lancet, 1, 417.CrossRefGoogle ScholarPubMed
Verster, J. P. (1963). Preliminary report on the treatment of mentally disordered patients by intrathecally administered phenothiazine drugs and an antiserotonin substance. South African Medical Journal, 37, 1086–89.Google Scholar
Winokur, G., Clayton, P. J., and Reich, T. (1969). Manic Depressive illness, p.63. Mosby: St. Louis.Google Scholar