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Intersection of verbal memory and expressivity on cortical contrast and thickness in first episode psychosis

Published online by Cambridge University Press:  28 August 2019

Carolina Makowski Open the ORCID record for Carolina Makowski [Opens in a new window] ,
John D. Lewis ,
Claude Lepage ,
Ashok K. Malla ,
Ridha Joober ,
Alan C. Evans  and
Martin Lepage
Carolina Makowski
Affiliation:
McGill Centre for Integrative Neuroscience, McGill University, Montreal, Canada McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada Ludmer Centre for Neuroinformatics and Mental Health, Montreal, Canada Department of Psychiatry, McGill University, Verdun, Canada
John D. Lewis
Affiliation:
McGill Centre for Integrative Neuroscience, McGill University, Montreal, Canada McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada Ludmer Centre for Neuroinformatics and Mental Health, Montreal, Canada
Claude Lepage*
Affiliation:
McGill Centre for Integrative Neuroscience, McGill University, Montreal, Canada McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada Ludmer Centre for Neuroinformatics and Mental Health, Montreal, Canada
Ashok K. Malla
Affiliation:
Department of Psychiatry, McGill University, Verdun, Canada Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Verdun, Canada
Ridha Joober
Affiliation:
Department of Psychiatry, McGill University, Verdun, Canada Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Verdun, Canada
Alan C. Evans
Affiliation:
McGill Centre for Integrative Neuroscience, McGill University, Montreal, Canada McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada Ludmer Centre for Neuroinformatics and Mental Health, Montreal, Canada
Martin Lepage*
Affiliation:
Department of Psychiatry, McGill University, Verdun, Canada Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Verdun, Canada
*
Author for correspondence: Martin Lepage, Email: martin.lepage@mcgill.ca
Author for correspondence: Martin Lepage, Email: martin.lepage@mcgill.ca
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Abstract

Background

Longitudinal studies of first episode of psychosis (FEP) patients are critical to understanding the dynamic clinical factors influencing functional outcomes; negative symptoms and verbal memory (VM) deficits are two such factors that remain a therapeutic challenge. This study uses white-gray matter contrast at the inner edge of the cortex, in addition to cortical thickness, to probe changes in microstructure and their relation with negative symptoms and possible intersections with verbal memory.

Methods

T1-weighted images and clinical data were collected longitudinally for patients (N = 88) over a two-year period. Cognitive data were also collected at baseline. Relationships between baseline VM (immediate/delayed recall) and rate of change in two negative symptom dimensions, amotivation and expressivity, were assessed at the behavioral level, as well as at the level of brain structure.

Results

VM, particularly immediate recall, was significantly and positively associated with a steeper rate of expressivity symptom decline (r = 0.32, q = 0.012). Significant interaction effects between baseline delayed recall and change in expressivity were uncovered in somatomotor regions bilaterally for both white-gray matter contrast and cortical thickness. Furthermore, interaction effects between immediate recall and change in expressivity on cortical thickness rates were uncovered across higher-order regions of the language processing network.

Conclusions

This study shows common neural correlates of language-related brain areas underlying expressivity and VM in FEP, suggesting deficits in these domains may be more linked to speech production rather than general cognitive capacity. Together, white-gray matter contrast and cortical thickness may optimally inform clinical investigations aiming to capture peri-cortical microstructural changes.

Keywords

Cortexcortical myelinearly psychosisimmediate recalllanguagenegative symptomsstructural imaging
Type
Original Articles
Information
Psychological Medicine , Volume 50 , Issue 11 , August 2020 , pp. 1923 - 1936
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Copyright
Copyright © Cambridge University Press 2019

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Footnotes

*

Authors share senior authorship.

References

Abramovic, L, Boks, MPM, Vreeker, A, Bouter, DC, Kruiper, C, Verkooijen, S, Van Bergen, AH, Ophoff, RA, Kahn, RS and Van Haren, NEM (2016) The association of antipsychotic medication and lithium with brain measures in patients with bipolar disorder. European Neuropsychopharmacology 26, 1741–1751.CrossRefGoogle ScholarPubMed
Akaike, H (1998) Information theory and an extension of the maximum likelihood principle. In Selected Papers of Hirotugu Akaike, Springer Series in Statistics. New York, NY: Springer New York, pp. 199–213.Google Scholar
Albert, N, Bertelsen, M, Thorup, A, Petersen, L, Jeppesen, P, Le Quack, P, Krarup, G, Jørgensen, P and Nordentoft, M (2011) Predictors of recovery from psychosis: analyses of clinical and social factors associated with recovery among patients with first-episode psychosis after 5 years. Schizophrenia Research 125, 257–266.CrossRefGoogle ScholarPubMed
Alexander, MP, Stuss, DT and Fansabedian, N (2003) California verbal learning test: performance by patients with focal frontal and non-frontal lesions. Brain 126, 1493–1503.CrossRefGoogle ScholarPubMed
Andreasen, N (1984) Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa.Google Scholar
Andreasen, NC, Ehrhardt, JC, Swayze, VW, Tyrrell, G, Cohen, G, Ku, JS and Arndt, S (1991) T1 and T2 relaxation times in schizophrenia as measured with magnetic resonance imaging. Schizophrenia Research 5, 223–232.CrossRefGoogle ScholarPubMed
Andreasen, NC, Nopoulos, P, Magnotta, V, Pierson, R, Ziebell, S and Ho, B-C (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biological Psychiatry 70, 672–679.CrossRefGoogle ScholarPubMed
Andrews, DS, Avino, TA, Gudbrandsen, M, Daly, E, Marquand, A, Murphy, CM, Lai, M-C, Lombardo, M V., Ruigrok, ANV, Williams, SC, Bullmore, ET, The MRC AIMS Consortium TMA, Suckling, J, Baron-Cohen, S, Craig, MC, Murphy, DGM and Ecker, C (2017) In vivo evidence of reduced integrity of the gray–white matter boundary in autism spectrum disorder. Cerebral Cortex 69, 63–70.Google Scholar
Asami, T, Hyuk Lee, S, Bouix, S, Rathi, Y, Whitford, TJ, Niznikiewicz, M, Nestor, P, McCarley, RW, Shenton, ME and Kubicki, M (2014) Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia. Psychiatry Research 222, 52–59.CrossRefGoogle Scholar
Bartzokis, G, Lu, PH, Stewart, SB, Oluwadara, B, Lucas, AJ, Pantages, J, Pratt, E, Sherin, JE, Altshuler, LL, Mintz, J, Gitlin, MJ, Subotnik, KL and Nuechterlein, KH (2009) In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia. Schizophrenia Research 113, 322–331.CrossRefGoogle ScholarPubMed
Benjamini, Y and Hochberg, Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society B 57, 289–300.Google Scholar
Benoit, A, Malla, AK, Iyer, SN, Joober, R, Bherer, L and Lepage, M (2015) Cognitive deficits characterization using the CogState Research Battery in first-episode psychosis patients. Schizophrenia Research: Cognition 2, 140–145.CrossRefGoogle ScholarPubMed
Birur, B, Kraguljac, NV, Shelton, RC and Lahti, AC (2017) Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder-a systematic review of the magnetic resonance neuroimaging literature. NPJ Schizophrenia 3, 15.CrossRefGoogle ScholarPubMed
Blanchard, JJ and Cohen, AS (2006) The structure of negative symptoms within schizophrenia: implications for assessment. Schizophrenia Bulletin 32, 238–245.CrossRefGoogle ScholarPubMed
Boucher, M, Whitesides, S and Evans, A (2009) Depth potential function for folding pattern representation, registration and analysis. Medical Image Analysis 13, 203–214.CrossRefGoogle ScholarPubMed
Cantor-Graae, E, Warkentin, S and Nilsson, A (1995) Neuropsychological assessment of schizophrenic patients during a psychotic episode: persistent cognitive deficit? Acta Psychiatrica Scandinavica 91, 283–288.CrossRefGoogle ScholarPubMed
Carletti, F, Woolley, JB, Bhattacharyya, S, Perez-Iglesias, R, Fusar Poli, P, Valmaggia, L, Broome, MR, Bramon, E, Johns, L, Giampietro, V, Williams, SCR, Barker, GJ and McGuire, PK (2012) Alterations in white matter evident before the onset of psychosis. Schizophrenia Bulletin 38, 1170–1179.CrossRefGoogle Scholar
Carrión, RE, McLaughlin, D, Auther, AM, Olsen, R, Correll, CU and Cornblatt, BA (2015) The impact of psychosis on the course of cognition: a prospective, nested case-control study in individuals at clinical high-risk for psychosis. Psychological Medicine 45, 3341–3354.CrossRefGoogle ScholarPubMed
Charlton, RA, Barrick, TR, Markus, HS and Morris, RG (2013) Verbal working and long-term episodic memory associations with white matter microstructure in normal aging investigated using tract-based spatial statistics. Psychology and Aging 28, 768–777.CrossRefGoogle ScholarPubMed
Cohen, AS and Elvevåg, B (2014) Automated computerized analysis of speech in psychiatric disorders. Current Opinion in Psychiatry 27, 203–209.CrossRefGoogle ScholarPubMed
Cohen, AS, Mitchell, KR and Elvevåg, B (2014) What do we really know about blunted vocal affect and alogia? A meta-analysis of objective assessments. Schizophrenia Research 159, 533–538.CrossRefGoogle ScholarPubMed
Collins, DL, Neelin, P, Peters, TM and Evans, AC (1994) Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. Journal of Computer Assisted Tomography 18, 192–205.CrossRefGoogle ScholarPubMed
Dazzan, P, Arango, C, Fleischacker, W, Galderisi, S, Glenthøj, B, Leucht, S, Meyer-Lindenberg, A, Kahn, R, Rujescu, D, Sommer, I, Winter, I and McGuire, P (2015) Magnetic resonance imaging and the prediction of outcome in first-episode schizophrenia: a review of current evidence and directions for future research. Schizophrenia Bulletin 41, 574–583.CrossRefGoogle ScholarPubMed
Friederici, AD (2011) The brain basis of language processing: from structure to function. Physiological Reviews 91, 1357–1392.CrossRefGoogle ScholarPubMed
Galderisi, S, Merlotti, E and Mucci, A (2015) Neurobiological background of negative symptoms. European Archives of Psychiatry and Clinical Neuroscience 265, 543–558.CrossRefGoogle ScholarPubMed
Ganzetti, M, Wenderoth, N and Mantini, D (2015) Mapping pathological changes in brain structure by combining T1- and T2-weighted MR imaging data. Neuroradiology 57, 917–928.CrossRefGoogle ScholarPubMed
Glasser, MF and Van Essen, DC (2011) Mapping human cortical areas in vivo based on myelin content as revealed by T1- and T2-weighted MRI. The Journal of Neuroscience 31, 11597–11616.CrossRefGoogle ScholarPubMed
Goldberg, TE, Torrey, EF, Gold, JM, Ragland, JD, Bigelow, LB and Weinberger, DR (1993) Learning and memory in monozygotic twins discordant for schizophrenia. Psychological Medicine 23, 71–85.CrossRefGoogle Scholar
Gong, Q, Lui, S and Sweeney, JA (2016) A selective review of cerebral abnormalities in patients with first-episode schizophrenia before and after treatment. American Journal of Psychiatry 173, 232–243.CrossRefGoogle ScholarPubMed
Green, MF and Harvey, PD (2014) Cognition in schizophrenia: past, present, and future. Schizophrenia Research Cognition 1, 1–21.CrossRefGoogle ScholarPubMed
Guimond, S, Chakravarty, MM, Bergeron-Gagnon, L, Patel, R and Lepage, M (2016) Verbal memory impairments in schizophrenia associated with cortical thinning. NeuroImage: Clinical 11, 20–29.CrossRefGoogle ScholarPubMed
Haber, SN (2016) Corticostriatal circuitry. Dialogues in Clinical Neuroscience 18, 7–21.Google ScholarPubMed
Hartmann-Riemer, MN, Hager, OM, Kirschner, M, Bischof, M, Kluge, A, Seifritz, E and Kaiser, S (2015) The association of neurocognitive impairment with diminished expression and apathy in schizophrenia. Schizophrenia Research 169, 427–432.CrossRefGoogle Scholar
Haukvik, UK, Hartberg, CB, Nerland, S, Jørgensen, KN, Lange, EH, Simonsen, C, Nesvåg, R, Dale, AM, Andreassen, OA, Melle, I and Agartz, I (2016) No progressive brain changes during a 1-year follow-up of patients with first-episode psychosis. Psychological Medicine 46, 589–598.CrossRefGoogle ScholarPubMed
Hoff, AL, Sakuma, M, Wieneke, M, Horon, R, Kushner, M and DeLisi, LE (1999) Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. American Journal of Psychiatry 156, 1336–1341.Google ScholarPubMed
Hovington, CL, Bodnar, M, Joober, R, Malla, AK and Lepage, M (2013) Impairment in verbal memory observed in first episode psychosis patients with persistent negative symptoms. Schizophrenia Research 147, 223–229.CrossRefGoogle ScholarPubMed
Insel, T, Cuthbert, B, Garvey, M, Heinssen, R, Pine, DS, Quinn, K, Sanislow, C and Wang, P (2010) Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. American Journal of Psychiatry 167, 748–751.CrossRefGoogle Scholar
Iwatani, J, Ishida, T, Donishi, T, Ukai, S, Shinosaki, K, Terada, M and Kaneoke, Y (2015) Use of T1-weighted/T2-weighted magnetic resonance ratio images to elucidate changes in the schizophrenic brain. Brain and Behavior 5, e00399.CrossRefGoogle ScholarPubMed
Iyer, S, Jordan, G, MacDonald, K, Joober, R and Malla, A (2015) Early intervention for psychosis: a Canadian perspective. The Journal of Nervous and Mental Disease 203, 356–364.CrossRefGoogle ScholarPubMed
Jang, S-K, Choi, H-I, Park, S, Jaekal, E, Lee, G-Y, Cho, Y Il and Choi, K-H (2016) A two-factor model better explains heterogeneity in negative symptoms: evidence from the positive and negative syndrome scale. Frontiers in Psychology 7, 707.CrossRefGoogle ScholarPubMed
Jones, SE, Buchbinder, BR and Aharon, I (2000) Three-dimensional mapping of cortical thickness using Laplace's equation. Human Brain Mapping 11, 12–32.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Jordan, G, Lutgens, D, Joober, R, Lepage, M, Iyer, SN and Malla, A (2014) The relative contribution of cognition and symptomatic remission to functional outcome following treatment of a first episode of psychosis. The Journal of Clinical Psychiatry 75, e566–e572.CrossRefGoogle ScholarPubMed
Jordan, G, Veru, F, Lepage, M, Joober, R, Malla, A and Iyer, SN (2018) Pathways to functional outcomes following a first episode of psychosis: the roles of premorbid adjustment, verbal memory and symptom remission. Australian & New Zealand Journal of Psychiatry 52, 793–803.CrossRefGoogle ScholarPubMed
June, SK, Singh, V, Jun, KL, Lerch, J, Ad-Dab'bagh, Y, MacDonald, D, Jong, ML, Kim, SI and Evans, AC (2005) Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. NeuroImage 27, 210–221.Google Scholar
Kelly, S, Jahanshad, N, Zalesky, A, Kochunov, P, Agartz, I, Alloza, C, Andreassen, OA, Arango, C, Banaj, N, Bouix, S, Bousman, CA, Brouwer, RM, Bruggemann, J, Bustillo, J, Cahn, W, Calhoun, V, Cannon, D, Carr, V, Catts, S, Chen, J, Chen, JX, Chen, X, Chiapponi, C, Cho, KK, Ciullo, V, Corvin, AS, Crespo-Facorro, B, Cropley, V, De Rossi, P, Diaz-Caneja, CM, Dickie, EW, Ehrlich, S, Fan, FM, Faskowitz, J, Fatouros-Bergman, H, Flyckt, L, Ford, JM, Fouche, JP, Fukunaga, M, Gill, M, Glahn, DC, Gollub, R, Goudzwaard, ED, Guo, H, Gur, RE, Gur, RC, Gurholt, TP, Hashimoto, R, Hatton, SN, Henskens, FA, Hibar, DP, Hickie, IB, Hong, LE, Horacek, J, Howells, FM, Hulshoff Pol, HE, Hyde, CL, Isaev, D, Jablensky, A, Jansen, PR, Janssen, J, Jönsson, EG, Jung, LA, Kahn, RS, Kikinis, Z, Liu, K, Klauser, P, Knöchel, C, Kubicki, M, Lagopoulos, J, Langen, C, Lawrie, S, Lenroot, RK, Lim, KO, Lopez-Jaramillo, C, Lyall, A, Magnotta, V, Mandl, RCW, Mathalon, DH, McCarley, RW, McCarthy-Jones, S, McDonald, C, McEwen, S, McIntosh, A, Melicher, T, Mesholam-Gately, RI, Michie, PT, Mowry, B, Mueller, BA, Newell, DT, O'Donnell, P, Oertel-Knöchel, V, Oestreich, L, Paciga, SA, Pantelis, C, Pasternak, O, Pearlson, G, Pellicano, GR, Pereira, A, Pineda Zapata, J, Piras, F, Potkin, SG, Preda, A, Rasser, PE, Roalf, DR, Roiz, R, Roos, A, Rotenberg, D, Satterthwaite, TD, Savadjiev, P, Schall, U, Scott, RJ, Seal, ML, Seidman, LJ, Shannon Weickert, C, Whelan, CD, Shenton, ME, Kwon, JS, Spalletta, G, Spaniel, F, Sprooten, E, Stäblein, M, Stein, DJ, Sundram, S, Tan, Y, Tan, S, Tang, S, Temmingh, HS, Westlye, LT, Tønnesen, S, Tordesillas-Gutierrez, D, Doan, NT, Vaidya, J, van Haren, NEM, Vargas, CD, Vecchio, D, Velakoulis, D, Voineskos, A, Voyvodic, JQ, Wang, Z, Wan, P, Wei, D, Weickert, TW, Whalley, H, White, T, Whitford, TJ, Wojcik, JD, Xiang, H, Xie, Z, Yamamori, H, Yang, F, Yao, N, Zhang, G, Zhao, J, van Erp, TGM, Turner, J, Thompson, PM and Donohoe, G (2018) Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA schizophrenia DTI working group. Molecular Psychiatry 23, 1261–1269.CrossRefGoogle ScholarPubMed
Kim, JS, Singh, V, Lee, JK, Lerch, J, Ad-Dab'bagh, Y, MacDonald, D, Lee, JM, Kim, SI and Evans, AC (2005) Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. NeuroImage 27, 210–221.CrossRefGoogle ScholarPubMed
Kirkpatrick, B, Fenton, WS, Carpenter, WT and Marder, SR (2006) The NIMH-MATRICS consensus statement on negative symptoms. Schizophrenia Bulletin 32, 214–219.CrossRefGoogle ScholarPubMed
Klauser, P, Baker, ST, Cropley, VL, Bousman, C, Fornito, A, Cocchi, L, Fullerton, JM, Rasser, P, Schall, U, Henskens, F, Michie, PT, Loughland, C, Catts, SV, Mowry, B, Weickert, TW, Shannon Weickert, C, Carr, V, Lenroot, R, Pantelis, C and Zalesky, A (2017) White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs. Schizophrenia Bulletin 43, 425–435.Google ScholarPubMed
Kubicki, M, Park, H, Westin, CF, Nestor, PG, Mulkern, RV, Maier, SE, Niznikiewicz, M, Connor, EE, Levitt, JJ, Frumin, M, Kikinis, R, Jolesz, FA, McCarley, RW and Shenton, ME (2005) DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity. NeuroImage 26, 1109–1118.CrossRefGoogle ScholarPubMed
Lake, EMR, Steffler, EA, Rowley, CD, Sehmbi, M, Minuzzi, L, Frey, BN and Bock, NA (2017) Altered intracortical myelin staining in the dorsolateral prefrontal cortex in severe mental illness. European Archives of Psychiatry and Clinical Neuroscience 267, 369–376.CrossRefGoogle ScholarPubMed
Lang, DJM, Yip, E, MacKay, AL, Thornton, AE, Vila-Rodriguez, F, MacEwan, GW, Kopala, LC, Smith, GN, Laule, C, MacRae, CB and Honer, WG (2014) 48 echo T2 myelin imaging of white matter in first-episode schizophrenia: evidence for aberrant myelination. NeuroImage. Clinical 6, 408–414.CrossRefGoogle ScholarPubMed
Lee, S-H, Kubicki, M, Asami, T, Seidman, LJ, Goldstein, JM, Mesholam-Gately, RI, McCarley, RW and Shenton, ME (2013) Extensive white matter abnormalities in patients with first-episode schizophrenia: a Diffusion Tensor Imaging (DTI) study. Schizophrenia Research 143, 231–238.CrossRefGoogle ScholarPubMed
Leeson, VC, Robbins, TW, Franklin, C, Harrison, M, Harrison, I, Ron, MA, Barnes, TRE and Joyce, EM (2009) Dissociation of long-term verbal memory and fronto-executive impairment in first-episode psychosis. Psychological Medicine 39, 1799.CrossRefGoogle ScholarPubMed
Lepage, M, Buchy, L, Bodnar, M, Bertrand, M-C, Joober, R and Malla, A (2008) Cognitive insight and verbal memory in first episode of psychosis. European Psychiatry 23, 368–374.CrossRefGoogle ScholarPubMed
Lepage, M, Bodnar, M and Bowie, CR (2014) Neurocognition: clinical and functional outcomes in schizophrenia. Canadian Journal of Psychiatry 59, 5–12.CrossRefGoogle Scholar
Lerch, JP and Evans, AC (2005) Cortical thickness analysis examined through power analysis and a population simulation. NeuroImage 24, 163–173.CrossRefGoogle Scholar
Lewis, JD, Evans, AC and Tohka, J (2018) T1 white/gray contrast as a predictor of chronological age, and an index of cognitive performance. NeuroImage 173, 341–450.CrossRefGoogle Scholar
Lindgren, M, Manninen, M, Kalska, H, Mustonen, U, Laajasalo, T, Moilanen, K, Huttunen, MO, Cannon, TD, Therman, S and Suvisaari, J (2017) Evaluation of verbal list learning as a predictor of psychosis. Early Intervention in Psychiatry 11, 171–176.CrossRefGoogle Scholar
Lutgens, D, Lepage, M, Iyer, S and Malla, A (2014) Predictors of cognition in first episode psychosis. Schizophrenia Research 152, 164–169.CrossRefGoogle ScholarPubMed
Lutgens, D, Iyer, S, Joober, R, Schmitz, N, Lepage, M, Mustafa, S and Malla, A (2019) Progress of negative symptoms during the critical period of the first five years of a first episode of psychosis. Psychological Medicine 49, 66–74.CrossRefGoogle Scholar
Lysaker, PH, Carcione, A, Dimaggio, G, Johannesen, JK, Nicolo, G, Procacci, M and Semerari, A (2005) Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life. Acta Psychiatrica Scandinavica 112, 64–71.CrossRefGoogle ScholarPubMed
Lyttelton, O, Boucher, M, Robbins, S and Evans, A (2007) An unbiased iterative group registration template for cortical surface analysis. NeuroImage 34, 1535–1544.CrossRefGoogle ScholarPubMed
MacDonald, K, Malla, A, Joober, R, Shah, JL, Goldberg, K, Abadi, S, Doyle, M and Iyer, SN (2018) Description, evaluation and scale-up potential of a model for rapid access to early intervention for psychosis. Early Intervention in Psychiatry 12, 1222–1228.CrossRefGoogle Scholar
Makowski, C, Bodnar, M, Malla, AK, Joober, R and Lepage, M (2016) Age-related cortical thickness trajectories in first episode psychosis patients presenting with early persistent negative symptoms. npj Schizophrenia 2, 16029.CrossRefGoogle ScholarPubMed
Makowski, C, Bodnar, M, Shenker, JJ, Malla, AK, Joober, R, Chakravarty, MM and Lepage, M (2017) Linking persistent negative symptoms to amygdala–hippocampus structure in first-episode psychosis. Translational Psychiatry 7, e1195.CrossRefGoogle ScholarPubMed
Makowski, C, Lewis, JD, Lepage, C, Malla, AK, Joober, R, Lepage, M and Evans, AC (2019) Structural associations in first episode psychosis using cortical contrast and cortical thickness. Cerebral Cortex In Press. doi: 10.1093/cercor/bhz040CrossRefGoogle Scholar
Malla, AK, Takhar, JJ, Norman, RMG, Manchanda, R, Cortese, L, Haricharan, R, Verdi, M and Ahmed, R (2002) Negative symptoms in first episode non-affective psychosis. Acta Psychiatrica Scandinavica 105, 431–439.CrossRefGoogle ScholarPubMed
Marder, SR and Galderisi, S (2017) The current conceptualization of negative symptoms in schizophrenia. World Psychiatry 16, 14–24.CrossRefGoogle Scholar
Messinger, JW, Trémeau, F, Antonius, D, Mendelsohn, E, Prudent, V, Stanford, AD and Malaspina, D (2011) Avolition and expressive deficits capture negative symptom phenomenology: implications for DSM-5 and schizophrenia research. Clinical Psychology Review 31, 161–168.CrossRefGoogle ScholarPubMed
Millan, MJ, Fone, K, Steckler, T and Horan, WP (2014) Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment. European Neuropsychopharmacology 24, 645–692.CrossRefGoogle ScholarPubMed
Mitelman, SA, Shihabuddin, L, Brickman, AM, Hazlett, EA and Buchsbaum, MS (2005) Volume of the cingulate and outcome in schizophrenia. Schizophrenia Research 72, 91–108.CrossRefGoogle Scholar
Mørch-Johnsen, L, Nesvåg, R, Faerden, A, Haukvik, UK, Jørgensen, KN, Lange, EH, Andreassen, OA, Melle, I and Agartz, I (2015) Brain structure abnormalities in first-episode psychosis patients with persistent apathy. Schizophrenia Research 164, 59–64.CrossRefGoogle ScholarPubMed
Mørch-Johnsen, L, Agartz, I and Jensen, J (2018) The neural correlates of negative symptoms in schizophrenia: examples from MRI literature. Clinical EEG and Neuroscience 49, 12–17.CrossRefGoogle ScholarPubMed
Nesvåg, R, Bergmann, Ø, Rimol, LM, Lange, EH, Haukvik, UK, Hartberg, CB, Fagerberg, T, Söderman, E, Jönsson, EG and Agartz, I (2012) A 5-year follow-up study of brain cortical and subcortical abnormalities in a schizophrenia cohort. Schizophrenia Research 142, 209–216.CrossRefGoogle Scholar
Nopoulos, P, Flashman, L, Flaum, M, Arndt, S and Andreasen, N (1994) Stability of cognitive functioning early in the course of schizophrenia. Schizophrenia Research 14, 29–37.CrossRefGoogle ScholarPubMed
Ochoa, S, Usall, J, Cobo, J, Labad, X and Kulkarni, J (2012) Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review. Schizophrenia Research and Treatment 2012, 1–9.Google ScholarPubMed
Ohtani, T, Bouix, S, Hosokawa, T, Saito, Y, Eckbo, R, Ballinger, T, Rausch, A, Melonakos, E and Kubicki, M (2014) Abnormalities in white matter connections between orbitofrontal cortex and anterior cingulate cortex and their associations with negative symptoms in schizophrenia: a DTI study. Schizophrenia Research 157, 190–197.CrossRefGoogle ScholarPubMed
Ohtani, T, Bouix, S, Lyall, AE, Hosokawa, T, Saito, Y, Melonakos, E, Westin, CF, Seidman, LJ, Goldstein, J, Mesholam-Gately, R, Petryshen, T, Wojcik, J and Kubicki, M (2015) Abnormal white matter connections between medial frontal regions predict symptoms in patients with first episode schizophrenia. Cortex 71, 264–276.CrossRefGoogle ScholarPubMed
Owen, M (2018) 9. Does biology read the DSM? Transdiagnostic findings in psychosis and implications for treatment. Schizophrenia Bulletin 44, S12–S13.CrossRefGoogle Scholar
Pietrzak, RH, Olver, J, Norman, T, Piskulic, D, Maruff, P and Snyder, PJ (2009) A comparison of the CogState schizophrenia battery and the measurement and treatment research to improve cognition in schizophrenia (MATRICS) battery in assessing cognitive impairment in chronic schizophrenia. Journal of Clinical and Experimental Neuropsychology 31, 848–859.CrossRefGoogle ScholarPubMed
Radua, J, Borgwardt, S, Crescini, A, Mataix-Cols, D, Meyer-Lindenberg, A, McGuire, PK and Fusar-Poli, P (2012) Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication. Neuroscience & Biobehavioral Reviews 36, 2325–2333.CrossRefGoogle ScholarPubMed
Raznahan, A, Lerch, JP, Lee, N, Greenstein, D, Wallace, GL, Stockman, M, Clasen, L, Shaw, PW and Giedd, JN (2011) Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling. Neuron 72, 873–884.CrossRefGoogle ScholarPubMed
Roiz-Santiáñez, R, Ortiz-García de la Foz, V, Ayesa-Arriola, R, Tordesillas-Gutiérrez, D, Jorge, R, Varela-Gómez, N, Suárez-Pinilla, P, Córdova-Palomera, A, Navasa-Melado, JM and Crespo-Facorro, B (2015) No progression of the alterations in the cortical thickness of individuals with schizophrenia-spectrum disorder: a three-year longitudinal magnetic resonance imaging study of first-episode patients. Psychological Medicine 45, 2861–2871.CrossRefGoogle ScholarPubMed
Salat, DH, Lee, SY, van der Kouwe, AJ, Greve, DN, Fischl, B and Rosas, HD (2009) Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast. NeuroImage 48, 21–28.CrossRefGoogle ScholarPubMed
Saur, D, Kreher, BW, Schnell, S, Kümmerer, D, Kellmeyer, P, Vry, M-S, Umarova, R, Musso, M, Glauche, V, Abel, S, Huber, W, Rijntjes, M, Hennig, J and Weiller, C (2008) Ventral and dorsal pathways for language. Proceedings of the National Academy of Sciences of the United States of America 105, 18035–18040.CrossRefGoogle ScholarPubMed
Sigmundsson, T, Suckling, J, Maier, M, Williams, SCR, Bullmore, ET, Greenwood, KE, Fukuda, R, Ron, MA and Toone, BK (2001) Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. American Journal of Psychiatry 158, 234–243.CrossRefGoogle ScholarPubMed
Sled, JG, Zijdenbos, AP and Evans, AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Transactions on Medical Imaging 17, 87–97.CrossRefGoogle ScholarPubMed
Smith, EE and Jonides, J (1999) Storage and executive processes in the frontal lobes. Science 283, 1657–1661.CrossRefGoogle ScholarPubMed
Smith, DM, Barredo, J and Mizumori, SJY (2012) Complimentary roles of the hippocampus and retrosplenial cortex in behavioral context discrimination. Hippocampus 22, 1121–1133.CrossRefGoogle ScholarPubMed
Smith, DM, Miller, AMP and Vedder, LC (2018) The retrosplenial cortical role in encoding behaviorally significant cues. Behavioral Neuroscience 132, 356–365.CrossRefGoogle ScholarPubMed
Strauss, GP, Nuñez, A, Ahmed, AO, Barchard, KA, Granholm, E, Kirkpatrick, B, Gold, JM and Allen, DN (2018) The latent structure of negative symptoms in schizophrenia. JAMA Psychiatry 75, 1271–1279.CrossRefGoogle Scholar
Szeszko, PR, Robinson, DG, Ikuta, T, Peters, BD, Gallego, JA, Kane, J and Malhotra, AK (2014) White matter changes associated with antipsychotic treatment in first-episode psychosis. Neuropsychopharmacology 39, 1324–1331.CrossRefGoogle ScholarPubMed
Tamnes, CK, Østby, Y, Fjell, AM, Westlye, LT, Due-Tønnessen, P and Walhovd, KB (2010) Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure. Cerebral Cortex 20, 534–548.CrossRefGoogle Scholar
Tohka, J, Zijdenbos, A and Evans, A (2004) Fast and robust parameter estimation for statistical partial volume models in brain MRI. NeuroImage 23, 84–97.CrossRefGoogle ScholarPubMed
Turetsky, B, Cowell, PE, Gur, RC, Grossman, RI, Shtasel, DL and Gur, RE (1995) Frontal and temporal lobe brain volumes in schizophrenia. Archives of General Psychiatry 52, 1061.CrossRefGoogle Scholar
Uranova, NA, Vikhreva, OV, Rachmanova, VI and Orlovskaya, DD (2011) Ultrastructural alterations of myelinated fibers and oligodendrocytes in the prefrontal cortex in schizophrenia: a postmortem morphometric study. Schizophrenia Research and Treatment 2011, 1–13.CrossRefGoogle ScholarPubMed
Vann, SD, Aggleton, JP and Maguire, EA (2009) What does the retrosplenial cortex do? Nature Reviews Neuroscience 10, 792–802.CrossRefGoogle Scholar
Vita, A, De Peri, L, Deste, G and Sacchetti, E (2012) Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies. Translational Psychiatry 2, e190.CrossRefGoogle ScholarPubMed
Wagstyl, K, Ronan, L, Whitaker, KJ, Goodyer, IM, Roberts, N, Crow, TJ and Fletcher, PC (2016) Multiple markers of cortical morphology reveal evidence of supragranular thinning in schizophrenia. Translational Psychiatry 6, e780.CrossRefGoogle Scholar
Walton, E, Hibar, DP, van Erp, TGM, Potkin, SG, Roiz-Santiañez, R, Crespo-Facorro, B, Suarez-Pinilla, P, van Haren, NEM, de Zwarte, SMC, Kahn, RS, Cahn, W, Doan, NT, Jørgensen, KN, Gurholt, TP, Agartz, I, Andreassen, OA, Westlye, LT, Melle, I, Berg, AO, Morch-Johnsen, L, Færden, A, Flyckt, L, Fatouros-Bergman, H, Jönsson, EG, Hashimoto, R, Yamamori, H, Fukunaga, M, Jahanshad, N, De Rossi, P, Piras, F, Banaj, N, Spalletta, G, Gur, RE, Gur, RC, Wolf, DH, Satterthwaite, TD, Beard, LM, Sommer, IE, Koops, S, Gruber, O, Richter, A, Krämer, B, Kelly, S, Donohoe, G, McDonald, C, Cannon, DM, Corvin, A, Gill, M, Di Giorgio, A, Bertolino, A, Lawrie, S, Nickson, T, Whalley, HC, Neilson, E, Calhoun, VD, Thompson, PM, Turner, JA, Ehrlich, S, Ehrlich, S and Karolinska Schizophrenia Project consortium (KaSP) (2017) Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine 48, 82–94.CrossRefGoogle ScholarPubMed
Wechsler, D (1997) Weschler Memory Scale, 3rd Edn. New York: The Psychological Corporation.Google Scholar
Wenger, E, Brozzoli, C, Lindenberger, U and Lövdén, M (2017) Expansion and renormalization of human brain structure during skill acquisition. Trends in Cognitive Sciences 21, 930–939.CrossRefGoogle ScholarPubMed
Westlye, LT, Walhovd, KB, Dale, AM, Espeseth, T, Reinvang, I, Raz, N, Agartz, I, Greve, DN, Fischl, B and Fjell, AM (2009) Increased sensitivity to effects of normal aging and Alzheimer's disease on cortical thickness by adjustment for local variability in gray/white contrast: a multi-sample MRI study. NeuroImage 47, 1545–1557.CrossRefGoogle ScholarPubMed
Whitford, TJ, Grieve, SM, Farrow, TFD, Gomes, L, Brennan, J, Harris, AWF, Gordon, E and Williams, LM (2007) Volumetric white matter abnormalities in first-episode schizophrenia: a longitudinal, tensor-based morphometry study. American Journal of Psychiatry 164, 1082–1089.CrossRefGoogle ScholarPubMed
Whitford, TJ, Ford, JM, Mathalon, DH, Kubicki, M and Shenton, ME (2012) Schizophrenia, myelination, and delayed corollary discharges: a hypothesis. Schizophrenia Bulletin 38, 486–494.CrossRefGoogle ScholarPubMed
Wible, CG, Anderson, J, Shenton, ME, Kricun, A, Hirayasu, Y, Tanaka, S, Levitt, JJ, O'Donnell, BF, Kikinis, R, Jolesz, FA and McCarley, RW (2001) Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study. Psychiatry Research 108, 65–78.CrossRefGoogle ScholarPubMed
Wolfers, T, Doan, NT, Kaufmann, T, Alnæs, D, Moberget, T, Agartz, I, Buitelaar, JK, Ueland, T, Melle, I, Franke, B, Andreassen, OA, Beckmann, CF, Westlye, LT and Marquand, AF (2018) Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models. JAMA Psychiatry 75, 1146–1155.CrossRefGoogle ScholarPubMed
Worsley, KJ, Taylor, JE, Tomaiuolo, F and Lerch, J (2004) Unified univariate and multivariate random field theory. NeuroImage 23, S189–S195.CrossRefGoogle ScholarPubMed
Zijdenbos, AP, Forghani, R and Evans, AC (2002) Automatic ‘pipeline’ analysis of 3-D MRI data for clinical trials: application to multiple sclerosis. IEEE Transactions on Medical Imaging 21, 1280–1291.CrossRefGoogle ScholarPubMed
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