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Immunological variability associated with experimentally-induced positive and negative affective states

Published online by Cambridge University Press:  09 July 2009

Ann D. Futterman ,
Margaret E. Kemeny ,
David Shapiro ,
William Polonsky  and
John L. Fahey
Ann D. Futterman*
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
Margaret E. Kemeny
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
David Shapiro
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
William Polonsky
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
John L. Fahey
Affiliation:
Departments of Psychology, Microbiology and Immunology, Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Los Angeles, California; Joslin Diabetes Center, Harvard School of Medicine, Boston, Massachusetts, USA
*
1 Address for correspondence: Dr Ann D. Futterman, Department of Rehabilitation Medicine, University of Colorado Health Sciences Center, Campus Box E243, 4701 East Ninth Avenue, Denver, Colorado 80262, USA.
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Synopsis

Functional and phenotypic immunological parameters were examined immediately before, after, and 30 minutes after experimentally-induced short-term positive (happiness) and negative (anxiety, depression) affective states and a neutral state, in five healthy subjects. Results indicated that all affective states induced more immune fluctuations (regardless of the direction) than the neutral state. Furthermore, among the affective states, anxiety induced the most immunological variability and depression the least.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 22 , Issue 1 , February 1992 , pp. 231 - 238
Copyright
Copyright © Cambridge University Press 1992

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References

Referemces

Albrecht, J., Helderman, J. H., Schlesser, M. A. & Rush, A. J. (1985). A controlled study of cellular immune function in affective disorders before and during somatic therapy. Psychiatry Research 15, 185–193.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1987). Diagnostic and Statistical Manual-III-Revised (DSM-III-R) (3rd edn, revised). American Psychiatric Association: Washington, DC.Google Scholar
Bulloch, K. (1985). Neuroanatomy of lymphoid tissue. In Neural Modulation of Immunity (ed. Guillemin, R., Cohen, M. and Melnechuk, T.), pp. 111–141. Raven Press: New York.Google Scholar
Calabrese, J., Skwerer, R., Barna, B., Gulledge, A., Valenzuela, R., Butkus, A., Subichin, S. & Krupp, N. E. (1986). Depression, immunocompetence, and prostaglandins of the E series. Psychiatry Research 17, 41–47.CrossRefGoogle ScholarPubMed
Darko, D. F., Rose, J., Gillin, J. C., Golshan, S. & Baird, S. M (1988). Neutrophilia and lymphopenia in major depressive disorders. Psychiatry Research 25, 2443–2451.CrossRefGoogle Scholar
Ekman, P., Levenson, R. W. & Friesen, W. V. (1983). Autonomic nervous system activity distinguishes among emotions. Science 221, 1208–1210.CrossRefGoogle ScholarPubMed
Felten, D., Felten, S., Bellinger, D., Carlson, S., Ackerman, K., Madden, K., Olschowki, J. & Livnat, S. (1987). Noradrenergic sympathetic neural innervation and the immune system: structure and function. Immunology Review 100, 225–260.CrossRefGoogle ScholarPubMed
Fridlund, A. J., Schwartz, G. E. & Fowler, A. C. (1984). Pattern recognition of self-reported states from multiple site facial EMG activity during imagery. Psychophysiology 21, 622–638.CrossRefGoogle ScholarPubMed
Greene, W., Betts, R., Ochitill, H., Iker, H. & Douglas, R. (1978). Psychosocial factors and immunity: preliminary report. Psychosomatic Medicine 16, 87.Google Scholar
Irwin, M., Daniels, M., Bloom, E., Smith, T. L. & Weiner, H. (1987). Life events, depressive symptoms, and immune function. American Journal of Psychiatry 144, 437–441.Google ScholarPubMed
Izard, C. E. (1972). Patterns of Emotions. Academic Press: New York.Google Scholar
Kemeny, M. E., Cohen, F., Zegans, L. S. & Conant, M. A. (1989). Psychological and immunological predictors of genital herpes recurrence. Psychosomatic Medicine 51, 195–208.CrossRefGoogle ScholarPubMed
Kronfol, Z. & House, J. (1984). Depression, cortisol, and immune function. Lancet i, 1026–1027.CrossRefGoogle Scholar
Kronfol, Z., Silva, J., Greden, J., Dembinski, S., Gardner, R. & Carroll, B. (1983). Impaired lymphocyte function in depressive illness. Life Sciences 33, 241–247.CrossRefGoogle ScholarPubMed
Kronfol, Z., House, J. D., Silva, J., Greden, J. & Carroll, B. J. (1986). Depression, urinary free cortisol excretion and lymphocyte function. British Journal of Psychiatry 48, 70–73.CrossRefGoogle Scholar
Linn, B. S., Linn, M. W. & Jensen, J. (1981). Anxiety and immune responsiveness. Psychological Reports 49, 969–970.CrossRefGoogle ScholarPubMed
Linn, M. W., Linn, B. S. & Jensen, J. (1984). Stressful events dysphoric mood, and immune responsiveness. Psychological Reports 54, 219–222.CrossRefGoogle ScholarPubMed
Livnat, S., Felten, S., Carlson, S. L., Bellinger, D. L. & Felten, D. L. (1985). Involvement of peripheral and central catecholamine systems in neural-immune interactions. Journal of Neuroimmunology 10, 5–30.CrossRefGoogle ScholarPubMed
Pross, H. F., Baines, M. G., Rubin, P., Shiragge, P. & Patterson, M. S. (1981). Spontaneous human lymphocyte-mediated cytotoxicity against tumour target cells. IX. The quantitation of natural killer cell activity. Journal of Clinical Immunology 1, 51–63.CrossRefGoogle ScholarPubMed
Schleifer, S. J., Keller, S. E., Meyerson, A. T., Raskin, J. J., Davis, K. L. & Stein, M. (1984). Lymphocyte function in major depressive disorders. Archives of General Psychiatry 41, 484–486.CrossRefGoogle Scholar
Schleifer, S. J., Keller, S. E., Siris, S. G., Davis, K. L. & Stein, M. (1985). Depression and immunity: lymphocyte function in ambulatory depressed patients, hospitalized schizophrenic patients, and patients hospitalized for herniorrhaphy. Archives of General Psychiatry 42, 129–133.CrossRefGoogle ScholarPubMed
Schleifer, S. J., Keller, S. E., Bond, R. N., Cohen, J. & Stein, M. (1989). Major depressive disorder and immunity: role of age, sex, severity, and hospitalization. Archives of General Psychiatry 46, 81–87.CrossRefGoogle ScholarPubMed
Schwartz, G. E., Weinberger, D. A. & Singer, J. A. (1981). Cardiovascular differentiation of happiness, sadness, anger and fear following imagery and exercise. Psychosomatic Medicine 43, 343–364.CrossRefGoogle ScholarPubMed
Stone, A. A., Cox, D. S., Valdimarsdottir, H., Jandorf, L. & Neale, J. M. (1987). Evidence that secretory IgA antibody is associated with daily mood. Journal of Personality and Social Psychology 52, 988–993.CrossRefGoogle ScholarPubMed
Watson, D. & Tellegen, A. (1985). Toward a consensual structure of mood. Psychological Bulletin 98, 219–235.CrossRefGoogle Scholar