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Disappearance of chlorpromazine from plasma following drug withdrawal

Published online by Cambridge University Press:  09 July 2009

Oliver Phillipson ,
Janet Baker ,
Frank Sebastianpillai ,
Graham Sheppard  and
Peter Brook
Oliver Phillipson
Affiliation:
the MRC Neurochemical Pharmacology Unit, University of Cambridge and Warley Hospital, Essex
Janet Baker
Affiliation:
the MRC Neurochemical Pharmacology Unit, University of Cambridge and Warley Hospital, Essex
Frank Sebastianpillai
Affiliation:
the MRC Neurochemical Pharmacology Unit, University of Cambridge and Warley Hospital, Essex
Graham Sheppard*
Affiliation:
the MRC Neurochemical Pharmacology Unit, University of Cambridge and Warley Hospital, Essex
Peter Brook
Affiliation:
the MRC Neurochemical Pharmacology Unit, University of Cambridge and Warley Hospital, Essex
*
3Address for correspondence: Dr Graham Sheppard, MRC Neurochemical Pharmacology Unit, Department of Pharmacology, Medical School, Hills Rd, Cambridge.
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Synopsis

Plasma chlorpromazine measured by a gas chromatographic procedure was found to disappear rapidly during the first week after withdrawal of chlorpromazine treatment in a group of 17 chronically hospitalized patients. The drug or its metabolites were no longer measurable in plasma after 8 days.

Type
Brief Communication
Information
Psychological Medicine , Volume 8 , Issue 2 , May 1978 , pp. 331 - 334
Copyright
Copyright © Cambridge University Press 1978

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