Hostname: page-component-848d4c4894-8bljj Total loading time: 0 Render date: 2024-07-06T18:57:10.206Z Has data issue: false hasContentIssue false
  • English
  • Français

Changes in serum tryptophan and albumin binding of tryptophan in chlorpromazine-treated chronic schizophrenics on withdrawal and restoration of drug therapy

Published online by Cambridge University Press:  09 July 2009

D. A. Bender ,
R. M. Pigache ,
J. Gruzelier  and
N. Hammond
D. A. Bender*
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
R. M. Pigache
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
J. Gruzelier
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
N. Hammond
Affiliation:
From the Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London, the Joint Neuropsychology Research Unit, Friern Hospital, London, and the Department of Clinical Pharmacology, University College Hospital Medical School, London
*
1Address for correspondence: Dr. D. A. Bender, Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London Wl P 5PR.
Get access Rights & Permissions [Opens in a new window]

Synopsis

Withdrawal of drug from a group of chlorpromazine-treated chronic male schizophrenics led to a significant rise in the initially low serum tryptophan concentration, and a rise in the fraction freely diffusible. These changes, which would be expected to lead to an increase in tryptophan influx into the brain, and hence to an increase in cerebral serotonin synthesis, could be related to the clinical effects of drug withdrawal.

Type
Original Article
Information
Psychological Medicine , Volume 5 , Issue 4 , November 1975 , pp. 397 - 403
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bender, D. A. (1975). The effect of single and repeated administration of chlorpromazine on serum tryptophan and albumin binding of tryptophan in the rat. Biochemical Society Transactions, 3, 115–117.CrossRefGoogle ScholarPubMed
Bender, D. A., and Bamji, A. N. (1974). Serum tryptophan binding in chlorpromazine-treated chronic schizophrenics. Journal of Neurochemistry, 22, 805–809.CrossRefGoogle ScholarPubMed
Bender, D. A., Boulton, A. P., and Coulson, W. F. (1975). A simple method for the study of tryptophan binding to serum albumin by small-scale equilibrium dialysis: application to animal and human studies. Biochemical Society Transactions, 3 193–194.CrossRefGoogle Scholar
Birkmayer, W., Danielczyk, W., Neumayer, E., and Riederer, P. (1974). Nucleus ruber and L-dopa psychosis: biochemical post-mortem findings. Journal of Neural Transmission, 35, 93–116.CrossRefGoogle ScholarPubMed
Blasberg, R., and Lajtha, A. (1965). Substrate specificity of steady-state amino acid transport in mouse brain slices. Archives of Biochemistry and Biophysics, 112, 361–377.CrossRefGoogle Scholar
Curzon, G., Friedel, J., Katamaneni, B. D., Greenwood, M. H., and Lader, M. H. (1974). Unesterified fatty acids and the binding of tryptophan in human plasma. Clinical Science and Molecular Medicine, 47, 415–424.Google ScholarPubMed
Denckla, W. D., and Dewey, H. K. (1967). The determination of tryptophan in plasma, liver, and urine. Journal of Laboratory and Clinical Medicine, 69, 160–169.Google ScholarPubMed
Few, J. D., and Cashmore, G. C. (1971). The determination of plasma Cortisol concentration by competitive protein binding. Annals of Clinical Biochemistry, 8, 205–209.CrossRefGoogle Scholar
Gilmour, D. G., Manowitz, P., Frosch, W. A., and Shopsin, B. (1973). Association of plasma tryptophan levels with clinical change in female schizophrenic patients. Biological Psychiatry, 6, 119–128.Google ScholarPubMed
Jéquier, E., Lovenberg, W., and Sjoerdsma, A. (1967). Tryptophan hydroxylase inhibition: mechanism by which p-chlorophenylalanine depletes rat brain serotonin. Molecular Pharmacology, 3, 274–278.Google ScholarPubMed
McMenamy, R. H., and Oncley, J. L. (1958). The specific binding of L-tryptophan to serum albumin. Journal of Biological Chemistry, 233, 1436–1447.Google Scholar
Maeda, M., and Tsuji, A. (1973). A fluorophotometric method for the detection of amino acids using pyridoxal and zinc (II) ion. Analytical Biochemistry, 52, 555–562.CrossRefGoogle Scholar
Manowitz, P., Gilmour, D. G., and Racevskis, J. (1973). Low plasma tryptophan levels in recently hospitalized schizophrenics. Biological Psychiatry, 6, 109–118.Google ScholarPubMed
Mikac-Devič, D., Stanković, H., and Bošković, K. (1973). A method for determination of free fatty acids in serum. Clinica Chinica Acta, 45, 55–59.Google Scholar
Prien, R. F., and Klett, C. J. (1972). An appraisal of the longterm use of tranquillizing medication with hospitalized chronic schizophrenics. Schizophrenia Bulletin, No. 5, 64–73.CrossRefGoogle Scholar
Rees, J. R., Allsopp, M. N. E., and Hullin, R. P. (1974). Plasma concentrations of tryptophan and other amino acids in manic-depressive patients. Psychological Medicine, 4, 334–337.Google Scholar