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Blood barbiturate levels in a patient dependent upon amylobarbitone sodium

Published online by Cambridge University Press:  09 July 2009

J. P. Watson  and
M. D. Radford
J. P. Watson
Affiliation:
Belhlem Royal and Maudsley Hospitals and the Institute of Psychiatry, London
M. D. Radford
Affiliation:
Belhlem Royal and Maudsley Hospitals and the Institute of Psychiatry, London
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Summary

In a barbiturate dependent patient, the blood barbiturate was less than 0·2 mg% two and a half hours after an oral dose of 200 mg amylobarbitone sodium. Amylobarbitone was withdrawn, and the patient was maintained on phenobarbitone, with a blood barbiturate level that remained at about 4·0 mg% over several weeks. Themost likelyexplanation of the findings is that the oxidation of amylobarbitone, but not phenobarbitone, is accelerated in patients dependent on the former drug.

Type
Research Article
Information
Psychological Medicine , Volume 1 , Issue 2 , February 1971 , pp. 178 - 180
Copyright
Copyright © Cambridge University Press 1971

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References

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