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ADP and arachidonic acid induced platelet aggregation in schizophrenia and atypical psychoses

Published online by Cambridge University Press:  09 July 2009

L. J. Whalley ,
H. W. Reading  and
R. Rosie
L. J. Whalley*
Affiliation:
MRC Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
H. W. Reading
Affiliation:
MRC Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
R. Rosie
Affiliation:
MRC Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
*
1 Address for correspondence: Dr L. J. Whalley MRC Brain Metabolism Unit, University Department of Pharmacology, I George Square, Edinburgh EH8 9JZ.
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Synopsis

Platelet aggregatory responses to adenosine diphosphate (ADP) and arachidonic acid were examined in 6 drug-free schizophrenics, 5 other drug-free psychotics, 8 ‘acute-on-chronic’ schizophrenics (on long-term neuroleptic therapy) and 38 healthy controls. Platelet aggregation and disaggregation following ADP was significantly lower in ‘acute-on-chronic’ schizophrenics (on drugs) compared with healthy controls, and disaggregation following 1 µM ADP was significantly less in drug-free schizophrenics. The difference between maximum aggregation induced by ADP and that induced by arachidonic acid was significantly greater in schizophrenics (both on drugs and drug-free) than in controls. These findings are related to possible abnormalities of central nervous system function in schizophrenia.

Type
Brief Communication
Information
Psychological Medicine , Volume 14 , Issue 1 , February 1984 , pp. 207 - 211
Copyright
Copyright © Cambridge University Press 1984

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