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Family history of alcohol dependence modulates functional neurophysiology in mood/anxiety disorders

Published online by Cambridge University Press:  04 October 2012

Z. Sjoerds
Affiliation:
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
M.-J. van Tol
Affiliation:
NeuroImaging Center, University Medical Center Groningen, Groningen, The Netherlands Clinical Affective Neuroimaging Laboratory, Leibniz Institute for Neurobiology, Otto von Guericke University, Magdeburg, Germany
W. van den Brink
Affiliation:
Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
N. J. A. van der Wee
Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands
A. Aleman
Affiliation:
NeuroImaging Center, University Medical Center Groningen, Groningen, The Netherlands
A. T. F. Beekman
Affiliation:
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
B. W. J. H. Penninx
Affiliation:
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands Department of Psychiatry, University Medical Center of Groningen, Groningen, The Netherlands
D. J. Veltman
Affiliation:
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Corresponding
E-mail address:

Abstract

Background

A family history (FH) of alcohol dependence (AD) not only increases the risk for AD, but is also associated with an increased risk for mood and anxiety disorders. However, it is unknown how a FH of AD affects neural substrates in patients with mood and anxiety disorders. In this study we examined the effects of an alcoholic FH on cognitive and emotional functions in these patients using functional magnetic resonance imaging (fMRI).

Method

In a sample of non-alcoholic patients with depressive and/or anxiety disorders from the Netherlands Study of Depression and Anxiety (NESDA) neuroimaging study, patients with a first-degree FH of AD (FH + ; n = 31) were compared with patients without a FH (FH–; n = 77) on performance and brain activation during visuospatial planning and emotional word encoding. Results were compared with those of healthy controls (HCs) without a FH of AD (n = 31).

Results

FH+ patients performed slower during planning with increasing task load, coupled with stronger blood oxygen level-dependent responses in dorsal prefrontal areas compared with FH− patients and HCs. FH was not associated with performance differences during word encoding, but right insula activation during positive word encoding was present in FH+ patients, comparable with HCs, but absent in FH− patients.

Conclusions

This study demonstrates subtle impairments during planning in FH+ compared with FH− patients and HCs, whereas activation during mood-incongruent stimuli in FH+ patients was similar to HCs but not FH− patients, suggesting that the presence of a FH of AD is a useful marker for the neurophysiological profile in mood/anxiety disorders and possible predictor for treatment success.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2012 

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References

Acheson, A, Robinson, JL, Glahn, DC, Lovallo, WR, Fox, PT (2009). Differential activation of the anterior cingulate cortex and caudate nucleus during a gambling simulation in persons with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. Drug and Alcohol Dependence 100, 1723.CrossRefGoogle ScholarPubMed
Andreasen, NC, Endicott, J, Spitzer, RL, Winokur, G (1977). The family history method using diagnostic criteria. Reliability and validity. Archives of General Psychiatry 34, 12291235.CrossRefGoogle ScholarPubMed
Araujo, NP, Monteiro, MG (1995). Family history of alcoholism and psychiatric co-morbidity in Brazilian male alcoholics and controls. Addiction 90, 12051211.CrossRefGoogle ScholarPubMed
Babor, TF, Kranzler, HR, Lauerman, RJ (1989). Early detection of harmful alcohol consumption: comparison of clinical, laboratory, and self-report screening procedures. Addictive Behaviors 14, 139157.CrossRefGoogle ScholarPubMed
Bartova, L, Berger, A, Pezawas, L (2010). Is there a personalized medicine for mood disorders? European Archives of Psychiatry and Clinical Neuroscience 260 (Suppl. 2), S121S126.CrossRefGoogle Scholar
Beck, AT, Epstein, N, Brown, G, Steer, RA (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology 56, 893897.CrossRefGoogle ScholarPubMed
Bjork, JM, Knutson, B, Hommer, DW (2008). Incentive-elirefd striatal activation in adolescent children of alcoholics. Addiction 103, 13081319.CrossRefGoogle ScholarPubMed
Bower, GH (1981). Mood and memory. American Psychologist 36, 129148.CrossRefGoogle ScholarPubMed
Bradley, BP, Mogg, K, Millar, N (1996). Implicit memory bias in clinical and non-clinical depression. Behaviour Research and Therapy 34, 865879.CrossRefGoogle ScholarPubMed
Burt, DB, Zembar, MJ, Niederehe, G (1995). Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity. Psychological Bulletin 117, 285305.CrossRefGoogle ScholarPubMed
Craig, AD (2003). Interoception: the sense of the physiological condition of the body. Current Opinion in Neurobiology 13, 500505.CrossRefGoogle Scholar
Daselaar, SM, Veltman, DJ, Rombouts, SA, Raaijmakers, JG, Jonker, C (2003). Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects. Brain 126, 4356.CrossRefGoogle Scholar
Dawson, DA, Grant, BF (1998). Family history of alcoholism and gender: their combined effects on DSM-IV alcohol dependence and major depression. Journal of Studies on Alcohol 59, 97106.CrossRefGoogle ScholarPubMed
Dolan, SL, Bechara, A, Nathan, PE (2008). Executive dysfunction as a risk marker for substance abuse: the role of impulsive personality traits. Behavioral Sciences and the Law 26, 799822.CrossRefGoogle ScholarPubMed
Drevets, WC, Price, JL, Furey, ML (2008). Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Structure and Function 213, 93118.CrossRefGoogle ScholarPubMed
Drummond, SP, Gillin, JC, Brown, GG (2001). Increased cerebral response during a divided attention task following sleep deprivation. Journal of Sleep Research 10, 8592.CrossRefGoogle ScholarPubMed
Drummond, SP, Meloy, MJ, Yanagi, MA, Orff, HJ, Brown, GG (2005). Compensatory recruitment after sleep deprivation and the relationship with performance. Psychiatry Research 140, 211223.CrossRefGoogle ScholarPubMed
Elliott, R, Rubinsztein, JS, Sahakian, BJ, Dolan, RJ (2002). The neural basis of mood-congruent processing biases in depression. Archives of General Psychiatry 59, 597604.CrossRefGoogle ScholarPubMed
Fitzgerald, PB, Laird, AR, Maller, J, Daskalakis, ZJ (2008). A meta-analytic study of changes in brain activation in depression. Human Brain Mapping 29, 683695.CrossRefGoogle ScholarPubMed
Friston, KJ, Holmes, AP, Poline, JB, Grasby, PJ, Williams, SC, Frackowiak, RS, Turner, R (1995). Analysis of fMRI time-series revisited. Neuroimage 2, 4553.CrossRefGoogle ScholarPubMed
Fyer, AJ, Weissman, MM (1999). Genetic linkage study of panic: clinical methodology and description of pedigrees. American Journal of Medical Genetics 88, 173181.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Glahn, DC, Lovallo, WR, Fox, PT (2007). Reduced amygdala activation in young adults at high risk of alcoholism: studies from the Oklahoma family health patterns project. Biological Psychiatry 61, 13061309.CrossRefGoogle ScholarPubMed
Hasin, D, Van Rossem, R, McCloud, S, Endicott, J (1997). Alcohol dependence and abuse diagnoses: validity in community sample heavy drinkers. Alcoholism, Clinical and Experimental Research 21, 213219.Google ScholarPubMed
Heatherton, TF, Kozlowski, LT, Frecker, RC, Fagerstrom, KO (1991). The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. British Journal of Addiction 86, 11191127.CrossRefGoogle ScholarPubMed
Heitzeg, MM, Nigg, JT, Yau, WY, Zubieta, JK, Zucker, RA (2008). Affective circuitry and risk for alcoholism in late adolescence: differences in frontostriatal responses between vulnerable and resilient children of alcoholic parents. Alcoholism, Clinical and Experimental Research 32, 414426.CrossRefGoogle ScholarPubMed
Hill, SY, De Bellis, MD, Keshavan, MS, Lowers, L, Shen, S, Hall, J, Pitts, T (2001). Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biological Psychiatry 49, 894905.CrossRefGoogle Scholar
Hill, SY, Kostelnik, B, Holmes, B, Goradia, D, McDermott, M, Diwadkar, V, Keshavan, M (2007). fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families. Alcoholism, Clinical and Experimental Research 31, 20282035.CrossRefGoogle ScholarPubMed
Hill, SY, Wang, S, Kostelnik, B, Carter, H, Holmes, B, McDermott, M, Zezza, N, Stiffler, S, Keshavan, MS (2009). Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families. Biological Psychiatry 65, 129136.CrossRefGoogle ScholarPubMed
Kanayama, G, Rogowska, J, Pope, HG, Gruber, SA, Yurgelun-Todd, DA (2004). Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology 176, 239247.CrossRefGoogle ScholarPubMed
Knappe, S, Lieb, R, Beesdo, K, Fehm, L, Low, NCP, Gloster, AT, Wittchen, HU (2009). The role of parental psychopathology and family environment for social phobia in the first three decades of life. Depression and Anxiety 26, 363370.CrossRefGoogle ScholarPubMed
Maldjian, JA, Laurienti, PJ, Kraft, RA, Burdette, JH (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19, 12331239.CrossRefGoogle ScholarPubMed
Menon, V, Uddin, LQ (2010). Saliency, switching, attention and control: a network model of insula function. Brain Structure and Function 214, 655667.CrossRefGoogle ScholarPubMed
Milne, BJ, Caspi, A, Harrington, H, Poulton, R, Rutter, M, Moffitt, TE (2009). Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence. Archives of General Psychiatry 66, 738747.CrossRefGoogle ScholarPubMed
Montgomery, SA, Asberg, M (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry: Journal of Mental Science 134, 382389.CrossRefGoogle ScholarPubMed
Moriyama, Y, Muramatsu, T, Kato, M, Mimura, M, Kashima, H (2006). Family history of alcoholism and cognitive recovery in subacute withdrawal. Psychiatry and Clinical Neurosciences 60, 8589.CrossRefGoogle ScholarPubMed
Nurnberger, JIJ, Wiegand, R, Bucholz, K, O'Connor, S, Meyer, ET, Reich, T, Rice, J, Schuckit, M, King, L, Petti, T, Bierut, L, Hinrichs, AL, Kuperman, S, Hesselbrock, V, Porjesz, B (2004). A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands. Archives of General Psychiatry 61, 12461256.CrossRefGoogle ScholarPubMed
Penick, EC, Powell, BJ, Bingham, SF, Liskow, BI, Miller, NS, Read, MR (1987). A comparative study of familial alcoholism. Journal of Studies on Alcohol 48, 136146.CrossRefGoogle ScholarPubMed
Penninx, BWJH, Beekman, ATF, Smit, JH, Zitman, FG, Nolen, WA, Spinhoven, P, Cuijpers, P, De Jong, PJ, Van Marwijk, HWJ, Assendelft, WJJ, Van Der Meer, K, Verhaak, P, Wensing, M, De Graaf, R, Hoogendijk, WJ, Ormel, J, Van Dyck, R (2008). The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. International Journal of Methods in Psychiatric Research 17, 121140.CrossRefGoogle ScholarPubMed
Peterson, JB, Finn, PR, Pihl, RO (1992). Cognitive dysfunction and the inherited predisposition to alcoholism. Journal of Studies on Alcohol 53, 154160.CrossRefGoogle ScholarPubMed
Petrakis, IL, Limoncelli, D, Gueorguieva, R, Jatlow, P, Boutros, NN, Trevisan, L, Gelernter, J, Krystal, JH (2004). Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. American Journal of Psychiatry 161, 17761782.CrossRefGoogle ScholarPubMed
Phelps, LE, Brutsche, N, Moral, JR, Luckenbaugh, DA, Manji, HK, Zarate, CA Jr. (2009). Family history of alcohol dependence and initial antidepressant response to an N-methyl-d-aspartate antagonist. Biological Psychiatry 65, 181184.CrossRefGoogle Scholar
Phillips, ML, Drevets, WC, Rauch, SL, Lane, R (2003 a). Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biological Psychiatry 54, 504514.CrossRefGoogle ScholarPubMed
Phillips, ML, Drevets, WC, Rauch, SL, Lane, R (2003 b). Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry 54, 515528.CrossRefGoogle ScholarPubMed
Poon, E, Ellis, DA, Fitzgerald, HE, Zucker, RA (2000). Intellectual, cognitive, and academic performance among sons of alcoholics, during the early school years: differences related to subtypes of familial alcoholism. Alcoholism, Clinical and Experimental Research 24, 10201027.CrossRefGoogle ScholarPubMed
Robins, LN, Wing, J, Wittchen, HU, Helzer, JE, Babor, TF, Burke, J, Farmer, A, Jablenski, A, Pickens, R, Regier, DA, Sartorius, N, Towle, LH (1988). The Composite International Diagnostic Interview. An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Archives of General Psychiatry 45, 10691077.CrossRefGoogle ScholarPubMed
Rush, AJ, Gullion, CM, Basco, MR, Jarrett, RB, Trivedi, MH (1996). The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychological Medicine 26, 477486.CrossRefGoogle ScholarPubMed
Schuckit, MA, Hesselbrock, VM, Tipp, J, Nurnberger, JI Jr., Anthenelli, RM, Crowe, RR (1995). The prevalence of major anxiety disorders in relatives of alcohol dependent men and women. Journal of Studies on Alcohol 56, 309317.CrossRefGoogle ScholarPubMed
Schweinsburg, AD, Paulus, MP, Barlett, VC, Killeen, LA, Caldwell, LC, Pulido, C, Brown, SA, Tapert, SF (2004). An FMRI study of response inhibition in youths with a family history of alcoholism. Annals of the New York Academy of Sciences 1021, 391394.CrossRefGoogle ScholarPubMed
Silveri, MM, Rogowska, J, McCaffrey, A, Yurgelun-Todd, DA (2011). Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance. Alcoholism, Clinical and Experimental Research 35, 218228.CrossRefGoogle ScholarPubMed
Sjoerds, Z, Van Tol, MJ, Van den Brink, W, Van der Wee, NJA, Van Buchem, MA, Aleman, A, Penninx, BW, Veltman, DJ (2012). Family history of alcohol dependence and gray matter abnormalities in non-alcoholic adults. World Journal of Biological Psychiatry. Published online 27 January 2012. doi: 10.3109/15622975.2011.640942.Google ScholarPubMed
Spadoni, AD, Norman, AL, Schweinsburg, AD, Tapert, SF (2008). Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. Alcoholism, Clinical and Experimental Research 32, 11351145.CrossRefGoogle ScholarPubMed
Tessner, KD, Hill, SY (2010). Neural circuitry associated with risk for alcohol use disorders. Neuropsychology Review 20, 120.CrossRefGoogle ScholarPubMed
Uher, R (2011). Genes, environment, and individual differences in responding to treatment for depression. Harvard Review of Psychiatry 19, 109124.CrossRefGoogle ScholarPubMed
Van den Heuvel, OA, Groenewegen, HJ, Barkhof, F, Lazeron, RH, Van Dyck, R, Veltman, DJ (2003). Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of Tower of London task. Neuroimage 18, 367374.CrossRefGoogle ScholarPubMed
Van Tol, MJ, Demenescu, LR, Van der Wee, NJA, Kortekaas, R, Nielen, MM, Den Boer, JA, Renken, R, van Buchem, MA, Zitman, FG, Aleman, A, Veltman, DJ (2012). Functional magnetic resonance imaging correlates of emotional word encoding and recognition in depression and anxiety disorders. Biological Psychiatry 71, 593602.CrossRefGoogle ScholarPubMed
Van Tol, MJ, Van der Wee, NJA, Demenescu, LR, Nielen, MM, Aleman, A, Renken, R, Van Buchem, MA, Zitman, FG, Veltman, DJ (2011). Functional MRI correlates of visuospatial planning in out-patient depression and anxiety. Acta Psychiatrica Scandinavica 124, 273284.CrossRefGoogle ScholarPubMed
Van Tol, MJ, Van der Wee, NJA, Van den Heuvel, OA, Nielen, MM, Demenescu, LR, Aleman, A, Renken, R, Van Buchem, MA, Zitman, FG, Veltman, DJ (2010). Regional brain volume in depression and anxiety disorders. Archives of General Psychiatry 67, 10021011.CrossRefGoogle ScholarPubMed
Van Wingen, G, Rijpkema, M, Franke, B, Van Eijndhoven, P, Tendolkar, I, Verkes, RJ, Buitelaar, J, Fernandez, G (2010). The brain-derived neurotrophic factor Val66Met polymorphism affects memory formation and retrieval of biologically salient stimuli. Neuroimage 50, 12121218.CrossRefGoogle ScholarPubMed
Wardenaar, KJ, Giltay, EJ, Van Veen, T, Zitman, FG, Penninx, BW (2012). Symptom dimensions as predictors of the two-year course of depressive and anxiety disorders. Journal of Affective Disorders 136, 11981203.CrossRefGoogle ScholarPubMed
Wetherill, RR, Bava, S, Thompson, WK, Boucquey, V, Pulido, C, Yang, TT, Tapert, SF (2011). Frontoparietal connectivity in substance-naive youth with and without a family history of alcoholism. Brain Research 1432, 6673.CrossRefGoogle ScholarPubMed
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