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Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis

Published online by Cambridge University Press:  28 November 2023

Ana Costas-Carrera
Affiliation:
Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain
Norma Verdolini
Affiliation:
Department of Mental Health, Umbria 1 Mental Health Center, Perugia, Italy
Clemente Garcia-Rizo*
Affiliation:
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Gisela Mezquida
Affiliation:
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Department of Basic Clinical Practice, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Joost Janssen
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
Isabel Valli*
Affiliation:
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Institute of Psychiatry Psychology and Neuroscience, King's College London, UK
Iluminada Corripio
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Department of Psychiatry, Institut d'Investigació Biomèdica Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Ana M. Sanchez-Torres
Affiliation:
Department of Psychiatry, Navarra University Hospital, Spain Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
Miquel Bioque
Affiliation:
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Antonio Lobo
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Department of Medicine and Psychiatry, University of Zaragoza, Zaragoza, Spain Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain
Ana Gonzalez-Pinto
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Department of Psychiatry, Hospital Universitario de Alava, UPV/EHU, BIOARABA, Spain
Marta Rapado-Castro
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia
Eduard Vieta
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Bipolar and Depressive Disorders Unit, Hospital Clinic de Barcelona, Institute of Neurosciences, Barcelona, Spain
Helena De la Serna
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Spain
Anna Mane
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Hospital del Mar Medical Research Institute (IMIM), Pompeu Fabra University, Barcelona, Spain
Alexandra Roldan
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Department of Psychiatry, Institut d'Investigació Biomèdica Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Nicolas Crossley
Affiliation:
Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
Rafael Penades
Affiliation:
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Manuel J. Cuesta
Affiliation:
Department of Psychiatry, Navarra University Hospital, Spain Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
Mara Parellada
Affiliation:
Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
Miquel Bernardo
Affiliation:
Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
PEPs group
Affiliation:
Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain
*
Corresponding author: Clemente Garcia-Rizo; Email: cgarcia3@clinic.cat; Isabel Valli; Email: ivalli@clinic.cat
Corresponding author: Clemente Garcia-Rizo; Email: cgarcia3@clinic.cat; Isabel Valli; Email: ivalli@clinic.cat

Abstract

Background

Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances.

Methods

We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis–Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups.

Results

FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio.

Conclusions

Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.

Type
Original Article
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

*

Both are first authors.

Both are senior authors.

PEPs group: M. Florencia Forte3,16, Jairo M. Gonzalez-Diaz3,22,23, Vito Cavone4,7, Celia Ordas4,7, Iñaki Zorrilla4,14, Saioa Lopez-Zurbano4,14, Concepcion De la Camara4,12,13, David Vaquero Puyuelo4,12,13, Juan Nacher4,24,25, Maria José Escartí Fabra4,25,26, Alba Toll Privat4,18, Laura Martínez Sadurní4,18, Sara Martín-Parra4,16, Derek Clougher4,16, Inmaculada Baeza4,5,17, J. Castro-Fornielles4,5,17, Fernando Contreras4,27, M. Paz García-Portilla4,28, Leticia González-Blanco4,28,29,30, Roberto Rodriguez-Jimenez4,31,32, Ángeles Sánchez-Cabezudo31, Judith Usall4,33, Anna Butjosa4,34, Salvador Sarro4,35, Edith Pomarol-Clotet4,35, Judit Selma4,9, Aina Àvila-Parcet4,9 and María Ribeiro10,11

22

UR Center for Mental Health-CERSAME, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia

23

Clinica Nuestra Señora de la Paz, Bogota, Colombia

24

Neurobiology Unit, Program in Neurosciences and Institute of Biotechnology and Biomedicine (BIOTECMED), Universitat de València, Burjassot, Spain

25

Biomedical Research Institute INCLIVA, Valencia, Spain

26

Department of Psychiatry, Hospital Clínico Universitario de Valencia, Valencia, Spain

27

Department of Psychiatry- Bellvitge University Hospital, Bellvitge Biomedical Research Institute IDIBELL, Hospitalet de Llobregat- Barcelona, Spain

28

Department of Psychiatry, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain

29

Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain

30

Servicio de Salud del Principado de Asturias (SESPA) Oviedo, Spain

31

Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain

32

Universidad Complutense de Madrid (UCM), Madrid, Spain

33

Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona

34

Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu of Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain

35

FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain

References

Amoretti, S., Rabelo-da-Ponte, F. D., Garriga, M., Forte, M. F., Penadés, R., Vieta, E., … Garcia-Rizo, C. (2022). Obstetric complications and cognition in schizophrenia: A systematic review and meta-analysis. Psychological Medicine, 52(14), 28742884. doi: 10.1017/s0033291722002409CrossRefGoogle ScholarPubMed
Baeza, I., De La Serna, E., Amoretti, S., Cuesta, M. J., Díaz-Caneja, C. M., Mezquida, G., … Balanza, V. (2021). Premorbid characteristics as predictors of early onset versus adult onset in patients with a first episode of psychosis. Journal of Clinical Psychiatry, 82(6), 21m13907. doi: 10.4088/JCP.21m13907.Google ScholarPubMed
Benedet, M. J., & Alexandre, M. A. (1998). Test de aprendizaje verbal españa-complutense (TAVEC) (TEA Ediciones). Madrid.Google Scholar
Benito-Cuadrado, M. M., Esteba-Castillo, S., Böhm, P., Cejudo-Bolívar, J., & Peña-Casanova, J. (2002). Semantic verbal fluency of animals: A normative and predictive study in a Spanish population. Journal of Clinical and Experimental Neuropsychology, 24(8), 11171122. doi: 10.1076/jcen.24.8.1117.8376CrossRefGoogle Scholar
Bora, E., & Murray, R. M. (2014). Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: Do the cognitive deficits progress over, or after, the onset of psychosis? Schizophrenia Bulletin, 40(4), 744755. doi: 10.1093/schbul/sbt085CrossRefGoogle ScholarPubMed
Bornstein, R. A., Schwarzkopf, S. B., Olson, S. C., & Nasrallah, H. A. (1992). Third-ventricle enlargement and neuropsychological deficit in schizophrenia. Biol Psychiatry, 31(9), 954961. doi: 10.1016/0006-3223(92)90121-FCrossRefGoogle ScholarPubMed
Borrajo, R. H., Zandio, M., Zarzuela, A., Serrano, J. F., Rosa, A., Fañanás, L., … Cuesta, M. J. (2011). Validity of maternal recall of obstetric complications in mothers of patients with schizophrenia spectrum disorders and their healthy siblings Schizophrenia Research, Vol. 126, pp. 308309. doi: 10.1016/j.schres.2010.09.017CrossRefGoogle Scholar
Bowie, C. R., & Harvey, P. D. (2006). Cognitive deficits and functional outcome in schizophrenia. Neuropsychiatric Disease and Treatment, 2(4), 531536. doi: 10.2147/nedt.2006.2.4.531CrossRefGoogle ScholarPubMed
Cannon, M., Jones, P. B., & Murray, R. M. (2002). Obstetric complications and schizophrenia: Historical and meta-analytic review. American Journal of Psychiatry, 159(7), 10801092. doi: 10.1176/appi.ajp.159.7.1080CrossRefGoogle ScholarPubMed
Collins, K. A., & Popek, E. (2018). Birth injury: Birth asphyxia and birth trauma. Academic Forensic Pathology, 8, 788864. doi: 10.1177/1925362118821468CrossRefGoogle ScholarPubMed
Costas-Carrera, A., Garcia-Rizo, C., Bitanihirwe, B., & Penadés, R. (2020). Obstetric complications and brain imaging in schizophrenia: A systematic review. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5, 10771084. doi: 10.1016/j.bpsc.2020.07.018Google ScholarPubMed
Cuesta, M. J., Lecumberri, P., Cabada, T., Moreno-Izco, L., Ribeiro, M., López-Ilundain, J. M., … Gómez, M. (2017). Basal ganglia and ventricle volume in first-episode psychosis. A family and clinical study. Psychiatry Research – Neuroimaging, 269, 9096. doi: 10.1016/j.pscychresns.2017.09.010CrossRefGoogle ScholarPubMed
Dars, S., Malik, S., Samreen, I., & Kazi, R. A. (2014). Maternal morbidity and perinatal outcome in preterm premature rupture of membranes before 37 weeks gestation. Pakistan Journal of Medical Sciences, 30(3), 626629. doi: 10.12669/pjms.303.4853Google ScholarPubMed
Davies, C., Segre, G., Estradé, A., Radua, J., De Micheli, A., Provenzani, U., … Fusar-Poli, P. (2020). Prenatal and perinatal risk and protective factors for psychosis: A systematic review and meta-analysis. The Lancet Psychiatry, 7(5), 399410. doi: 10.1016/S2215-0366(20)30057-2CrossRefGoogle ScholarPubMed
Dazzan, P., Arango, C., Fleischacker, W., Galderisi, S., Glenthøj, B., Leucht, S., … McGuire, P. (2015). Magnetic resonance imaging and the prediction of outcome in first-episode schizophrenia: A review of current evidence and directions for future research. Schizophrenia Bulletin, 41(3), 574583. doi: 10.1093/schbul/sbv024CrossRefGoogle ScholarPubMed
De Haan, M., Wyatt, J. S., Roth, S., Vargha-Khadem, F., Gadian, D., & Mishkin, M. (2006). Brain and cognitive-behavioural development after asphyxia at term birth. Developmental Science, 9(4), 350358. doi: 10.1111/j.1467-7687.2006.00499.xCrossRefGoogle ScholarPubMed
de Mélo Silva Júnior, M. L., Diniz, P. R. B., de Souza Vilanova, M. V., Basto, G. P. T., & Valença, M. M. (2022). Brain ventricles, CSF and cognition: A narrative review. Psychogeriatrics: The Official Journal of the Japanese Psychogeriatric Society, 22(4), 544552. doi: 10.1111/PSYG.12839CrossRefGoogle ScholarPubMed
Ecevit, A., Anuk-Ince, D., Yapakç, E., Kupana-Ayva, Ş, Kurt, A., Yanik, F. F., & Tarcan, A. (2014). Association of respiratory distress syndrome and perinatal hypoxia with histologic chorioamnionitis in preterm infants. Turkish Journal of Pediatrics, 56(1), 5661.Google ScholarPubMed
Falkai, P., Schneider-Axmann, T., Honer, W. G., Vogeley, K., Schönell, H., Pfeiffer, U., … Tepest, R. (2003). Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: A MRI study. European Archives of Psychiatry and Clinical Neuroscience, 253(2), 9299. doi: 10.1007/s00406-003-0414-9CrossRefGoogle ScholarPubMed
Fannon, D., Tennakoon, L., Sumich, A., O'Ceallaigh, S., Doku, V., Chitnis, X., … Sharma, T. (2000). Third ventricle enlargement and developmental delay in first-episode psychosis: Preliminary findings. The British Journal of Psychiatry: The Journal of Mental Science, 177(OCT.), 354359. doi: 10.1192/BJP.177.4.354CrossRefGoogle ScholarPubMed
García-Rizo, C., Bioque, M., Mezquida, G., Amoretti, S., Cuesta, M. J., Díaz-Caneja, C. M., … Selva-Vera, G. (2020). Birth weight and antipsychotic induced weight gain: A prenatal programming approach in the PEPs study. Schizophrenia Research, 218, 292294. doi: 10.1016/j.schres.2019.12.030CrossRefGoogle ScholarPubMed
Garcia-Rizo, C., Cabrera, B., Bioque, M., Mezquida, G., Lobo, A., Gonzalez-Pinto, A., … GROUP, Pep. (2022). The effect of early life events on glucose levels in first-episode psychosis. Frontiers in Endocrinology, 13, 2696. doi: 10.3389/FENDO.2022.983792CrossRefGoogle ScholarPubMed
Garriga, M., Fernandez-Egea, E., Mallorqui, A., Serrano, L., Oliveira, C., Parellada, E., … Garcia-Rizo, C. (2019). Antipsychotic-induced weight gain and birth weight in psychosis: A fetal programming model. Journal of Psychiatric Research, 115, 2935. doi: 10.1016/j.jpsychires.2019.05.004CrossRefGoogle ScholarPubMed
Gaser, C., Nenadic, I., Buchsbaum, B. R., Hazlett, E. A., & Buchsbaum, M. S. (2004). Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex. American Journal of Psychiatry, 161(1), 154156. doi: 10.1176/APPI.AJP.161.1.154/ASSET/IMAGES/LARGE/M424F1.JPEGCrossRefGoogle ScholarPubMed
Golden, C. J. (1978). Stroop color and word test. A manual for clinical and experimental uses. (Wood Dale, Illinois Stoelting Company). Illinois.Google Scholar
Haijma, S. V., Van Haren, N., Cahn, W., Koolschijn, P. C. M. P. P., Hulshoff Pol, H. E., & Kahn, R. S. (2013). Brain volumes in schizophrenia: A meta-analysis in over 18 000 subjects. Schizophrenia Bulletin, 39(5), 11291138. doi: 10.1093/schbul/sbs118CrossRefGoogle ScholarPubMed
Haukvik, U. K., McNeil, T., Nesvåg, R., Söderman, E., Jönsson, E., & Agartz, I. (2010a). No effect of obstetric complications on basal ganglia volumes in schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(4), 619623. doi: 10.1016/j.pnpbp.2010.02.024CrossRefGoogle ScholarPubMed
Haukvik, U. K., Saetre, P., McNeil, T., Bjerkan, P. S., Andreassen, O. A., Werge, T., … Agartz, I. (2010b). An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(7), 12591265. doi: 10.1016/j.pnpbp.2010.07.001CrossRefGoogle Scholar
Haukvik, U. K., Schaer, M., Nesvåg, R., McNeil, T., Hartberg, C. B., Jönsson, E. G., … Agartz, I. (2012). Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls. Psychological Medicine, 42(6), 13291337. doi: 10.1017/S0033291711002315CrossRefGoogle ScholarPubMed
Heaton, R. (1993). Wisconsin card sorting test manual. Odessa, Florida: Psychological Assessment Resources.Google Scholar
Herrera-Marschitz, M., Neira-Pena, T., Rojas-Mancilla, E., Espina-Marchant, P., Esmar, D., Perez, R., … Gebicke-Haerter, P. J. (2014). Perinatal asphyxia: CNS development and deficits with delayed onset. Frontiers in Cellular Neuroscience, 26(8), 47. doi: 10.3389/fnins.2014.00047Google Scholar
Homack, S., & Riccio, C. A. (2006). Conners’ continuous performance test (2nd ed.; CCPT-II). Journal of Attention Disorders, 9(3), 556558. doi: 10.1177/1087054705283578CrossRefGoogle ScholarPubMed
Jacobi, W., & Winkler, H. (1927). Encephalographische studien an chronisch schizophrenen. Archiv Für Psychiatrie Und Nervenkrankheiten, 81(1), 299332. doi: 10.1007/BF01825649CrossRefGoogle Scholar
Johnstone, E. C., Frith, C. D., Crow, T. J., Husband, J., & Kreel, L. (1976). Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet (London, England), 2(7992), 924926. doi: 10.1016/S0140-6736(76)90890-4CrossRefGoogle ScholarPubMed
Kirkpatrick, B., Miller, B., Garcia-Rizo, C., Fernandez-Egea, E., García-Rizo, C., & Fernandez-Egea, E. (2013). Schizophrenia. Clin Schizophr Relat Psychoses, 8(2), 7379. doi: 10.3371/CSRP.KIMI.0315131626661L777U2665 [pii]CrossRefGoogle Scholar
Konishi, J., del Re, E. C., Bouix, S., Blokland, G. A. M., Mesholam-Gately, R., Woodberry, K., … McCarley, R. W. (2018). Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: A pilot study. Brain Imaging and Behavior, 12(4), 974988. doi: 10.1007/s11682-017-9758-zCrossRefGoogle ScholarPubMed
Kuo, S. S., & Pogue-Geile, M. F. (2019). Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies. Neuroscience & Biobehavioral Reviews, 98, 8594. doi: 10.1016/J.NEUBIOREV.2018.12.030CrossRefGoogle ScholarPubMed
Leung, T. Y., & Lao, T. T. (2013). Timing of caesarean section according to urgency. Best Practice and Research: Clinical Obstetrics and Gynaecology, 27(2), 251267. doi: 10.1016/j.bpobgyn.2012.09.005Google ScholarPubMed
Lewis, S., Owen, M., & Murray, R. (1989). Obstetric complications and schizophrenia: Methodology and mechanisms. In Schulz, S. & Tamminga, C. (Eds.), Schizophrenia: Scientific progress (pp. 5668). New York, NY: Oxford University Press.Google Scholar
Lizano, P., Lutz, O., Ling, G., Lee, A. M., Eum, S., Bishop, J. R., … Keshavan, M. (2019). Association of choroid plexus enlargement with cognitive, inflammatory, and structural phenotypes across the psychosis spectrum. American Journal of Psychiatry, 176(7), 564572. doi: 10.1176/appi.ajp.2019.18070825CrossRefGoogle ScholarPubMed
Manning, V., Betteridge, S., Wanigaratne, S., Best, D., Strang, J., & Gossop, M. (2009). Cognitive impairment in dual diagnosis inpatients with schizophrenia and alcohol use disorder. Schizophrenia Research, 114(1–3), 98104. doi: 10.1016/j.schres.2009.05.020CrossRefGoogle ScholarPubMed
McCarley, R. W., Wible, C. G., Frumin, M., Hirayasu, Y., Levitt, J. J., Fischer, I. A., & Shenton, M. E. (1999). MRI anatomy of schizophrenia. Biological Psychiatry, 45, 10991119. doi: 10.1016/S0006-3223(99)00018-9CrossRefGoogle ScholarPubMed
Mercogliano, C., & Poddar, K. (2021). Long-term comorbid neuropsychiatric sequelae of hypoxia at birth. Cureus, 13(1), e12687. doi: 10.7759/cureus.12687Google ScholarPubMed
Mezquida, G., Amoretti, S., Bioque, M., García-Rizo, C., Sánchez-Torres, A. M., Pina-Camacho, L., … Bernardo, M. (2023). Identifying risk factors for predominant negative symptoms from early stages in schizophrenia: A longitudinal and sex-specific study in first-episode schizophrenia patients. Revista de Psiquiatria y Salud Mental, S1888-9891(23)00005-8. doi: 10.1016/j.rpsm.2023.01.004Google ScholarPubMed
Mezquida, G., Fernández-Egea, E., Treen, D., Mané, A., Bergé, D., Savulich, G., … García-Rizo, C. (2021). Difficulties in delivery and depressive symptomatology in schizophrenia. Revista de Psiquiatria y Salud Mental, 14(1), 6668. doi: 10.1016/j.rpsm.2019.12.002CrossRefGoogle ScholarPubMed
Mezquida, G., Fernandez-Egea, E., Treen, D., Mané, A., Bergé, D., Savulich, G., … Garcia-Rizo, C. (2018). Obstetric phenotypes in the heterogeneity of schizophrenia. Journal of Nervous and Mental Disease, 206(11), 882886. doi: 10.1097/NMD.0000000000000897CrossRefGoogle ScholarPubMed
Mukhopadhyay, S., & Arulkumaran, S. (2002). Breech delivery. Best Practice and Research: Clinical Obstetrics and Gynaecology, 16(1), 3142. doi: 10.1053/beog.2001.0253Google ScholarPubMed
Murray, R. M., Bhavsar, V., Tripoli, G., & Howes, O. (2017). 30 years on: How the neurodevelopmental hypothesis of schizophrenia morphed into the developmental risk factor model of psychosis. Schizophrenia Bulletin, 43(6), 11901196. doi: 10.1093/schbul/sbx121CrossRefGoogle ScholarPubMed
Nakamura, K., Kawasaki, Y., Suzuki, M., Hagino, H., Kurokawa, K., Takahashi, T., … Kurachi, M. (2004). Multiple structural brain measures obtained by three-dimensional magnetic resonance imaging to distinguish between schizophrenia patients and normal subjects. Schizophrenia Bulletin, 30(2), 393404. doi: 10.1093/oxfordjournals.schbul.a007087CrossRefGoogle ScholarPubMed
Nakamura, M., Salisbury, D. F., Hirayasu, Y., Bouix, S., Pohl, K. M., Yoshida, T., … McCarley, R. W. (2007). Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: A cross-sectional and longitudinal MRI study. Biological Psychiatry, 62(7), 773783. doi: 10.1016/j.biopsych.2007.03.030CrossRefGoogle ScholarPubMed
Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., … Marder, S. R. (2008). The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity. The American Journal of Psychiatry, 165, 203213. doi: 10.1176/appi.ajp.2007.07010042CrossRefGoogle ScholarPubMed
Peralta, V., de Jalón, E. G., Campos, M. S., Zandio, M., Sanchez-Torres, A., & Cuesta, M. J. (2011). The meaning of childhood attention-deficit hyperactivity symptoms in patients with a first-episode of schizophrenia-spectrum psychosis. Schizophrenia Research, 126(1–3), 2835. doi: 10.1016/J.SCHRES.2010.09.010CrossRefGoogle ScholarPubMed
Peralta, V., García de Jalón, E., Moreno-Izco, L., Peralta, D., Janda, L., Sánchez-Torres, A. M., … Zandio, M. (2022). Long-term outcomes of first-admission psychosis: A naturalistic 21-year follow-up study of symptomatic, functional and personal recovery and their baseline predictors. Schizophrenia Bulletin, 48(3), 631642. doi: 10.1093/schbul/sbab145CrossRefGoogle ScholarPubMed
Reitan, R. M., & Wolfson, D. (1995). Category test and trail making test as measures of frontal lobe functions. The Clinical Neuropsychologist, 9(1), 5056. doi: 10.1080/13854049508402057CrossRefGoogle Scholar
Reitan, R. M., & Wolfson, D. (2001). The Halstead–Reitan neuropsychological test battery: Research findings and clinical application. In Cambridge Child and Adolescent Psychiatry (Eds.), Specific learning disabilities and difficulties in children and adolescents: Psychological assessment and evaluation (pp. 309346). New York, NY, USA: Cambridge University Press. doi: 10.1017/CBO9780511526794.011CrossRefGoogle Scholar
Rosso, I. M., Cannon, T. D., Huttunen, T., Huttunen, M. O., Lönnqvist, J., & Gasperoni, T. L. (2000). Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. American Journal of Psychiatry, 157(5), 801807. doi: 10.1176/appi.ajp.157.5.801CrossRefGoogle Scholar
Ruff, R. M., Light, R. H., Parker, S. B., & Levin, H. S. (1996). Benton controlled oral word association test: Reliability and updated norms. Archives of Clinical Neuropsychology, 11(4), 329338. doi: 10.1016/0887-6177(95)00033-XCrossRefGoogle ScholarPubMed
Sagué-Vilavella, M., Amoretti, S., Garriga, M., Mezquida, G., Williams, E., Serra-Navarro, M., … Verdolini, N. (2022). Shaped before birth: Obstetric complications identify a more severe clinical phenotype among patients presenting a first affective or non-affective episode of psychosis. Journal of Psychiatric Research, 151, 461468. doi: 10.1016/j.jpsychires.2022.05.005CrossRefGoogle ScholarPubMed
Salagre, E., Arango, C., Artigas, F., Ayuso-Mateos, J. L., Bernardo, M., Castro-Fornieles, J., … Vieta, E. (2019). CIBERSAM: Ten years of collaborative translational research in mental disorders. Revista de Psiquiatria y Salud Mental, 12(1), 18. doi: 10.1016/j.rpsm.2018.10.001CrossRefGoogle ScholarPubMed
Sánchez-Torres, A. M., Peralta, V., Gil-Berrozpe, G. J., Mezquida, G., Ribeiro, M., Molina-García, M., … Balanzá-Martínez, V. (2022). The network structure of cognitive deficits in first episode psychosis patients. Schizophrenia Research, 244, 4654. doi: 10.1016/j.schres.2022.05.005CrossRefGoogle Scholar
Sasabayashi, D., Takayanagi, Y., Takahashi, T., Katagiri, N., Sakuma, A., Obara, C., … Suzuki, M. (2020). Subcortical brain volume abnormalities in individuals with an at-risk mental state. Schizophrenia Bulletin, 46(4), 834845. doi: 10.1093/schbul/sbaa011CrossRefGoogle ScholarPubMed
Smeland, O. B., Wang, Y., Frei, O., Li, W., Hibar, D. P., Franke, B., … Andreassen, O. A. (2018). Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms. Schizophrenia Bulletin, 44(4), 854864. doi: 10.1093/schbul/sbx148CrossRefGoogle ScholarPubMed
Smith, G. N., Thornton, A. E., Lang, D. J., MacEwan, G. W., Kopala, L. C., Su, W., & Honer, W. G. (2015). Cortical morphology and early adverse birth events in men with first-episode psychosis. Psychological Medicine, 45(9), 18251837. doi: 10.1017/S003329171400292XCrossRefGoogle ScholarPubMed
Tate, D. F. (2018). Ventricle-to-Brain (VBR) ratio BT. In Kreutzer, J. S., DeLuca, J. & Caplan, B. (Eds.), Encyclopedia of clinical neuropsychology. Cham: Springer International Publishing, pp 12. doi: 10.1007/978-3-319-57111-9_9075Google Scholar
Ursini, G., Punzi, G., Chen, Q., Marenco, S., Robinson, J. F., Porcelli, A., … Weinberger, D. R. (2018). Convergence of placenta biology and genetic risk for schizophrenia article. Nature Medicine, 24(6), 792801. doi: 10.1038/s41591-018-0021-yCrossRefGoogle Scholar
Valli, I., Segura, A. G., Verdolini, N., Garcia-Rizo, C., Berge, D., Baeza, I., … Zorrilla, I. (2023). Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis. Acta Psychiatrica Scandinavica, 148(1), 8190. doi: 10.1111/acps.13546CrossRefGoogle ScholarPubMed
Valli, I., Tognin, S., Fusar-Poli, P., & Mechelli, A. (2012). Episodic memory dysfunction in individuals at high-risk of psychosis: A systematic review of neuropsychological and neurofunctional studies. Current Pharmaceutical Design, 18(4), 443458. doi: 10.2174/138161212799316271CrossRefGoogle ScholarPubMed
Van Horn, J. D., & McManus, I. C. (1992). Ventricular enlargement in schizophrenia. A meta-analysis of studies of the ventricle:brain ratio (VBR). The British Journal of Psychiatry: The Journal of Mental Science, 160(MAY.), 687697. doi: 10.1192/BJP.160.5.687CrossRefGoogle ScholarPubMed
Vassos, E., Kou, J., Tosato, S., Maxwell, J., Dennison, C. A., Legge, S. E., … Murray, R. M. (2022). Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin, 48(1), 2026. doi: 10.1093/SCHBUL/SBAB052CrossRefGoogle ScholarPubMed
Verdolini, N., Mezquida, G., Valli, I., Garcia-Rizo, C., Cuesta, M., Vieta, E., … Balanzá-Martínez, V. (2023). Obstetric complications and clinical presentation in first episode of psychosis. Acta Neuropsychiatrica, 35(3), 156164. doi: 10.1017/neu.2023.9CrossRefGoogle ScholarPubMed
Wells, R., Jacomb, I., Swaminathan, V., Sundram, S., Weinberg, D., Bruggemann, J., … Weickert, T. W. (2020). The impact of childhood adversity on cognitive development in schizophrenia. Schizophrenia Bulletin, 46(1), 140153. doi: 10.1093/schbul/sbz033CrossRefGoogle ScholarPubMed
Weschler, D. (1997). Wechsler adult intelligence scale-III (WAIS-III). San Antonio, TX: The Psychological Association.Google Scholar
Wortinger, L. A., Barth, C., Nerland, S., Jørgensen, K. N., Shadrin, A. A., Szabo, A., … Agartz, I. (2021). Association of birth asphyxia with regional white matter abnormalities among patients with schizophrenia and bipolar disorders. JAMA Network Open, 4(12), e2139759. doi: 10.1001/jamanetworkopen.2021.39759CrossRefGoogle ScholarPubMed
Wortinger, L. A., Engen, K., Barth, C., Andreassen, O. A., Nordbø Jørgensen, K., & Agartz, I. (2020). Asphyxia at birth affects brain structure in patients on the schizophrenia-bipolar disorder spectrum and healthy participants. Psychological Medicine, 52(6), 10501059. doi: 10.1017/S0033291720002779CrossRefGoogle ScholarPubMed
Wright, I. C., Rabe-Hesketh, S., Woodruff, P. W. R., David, A. S., Murray, R. M., & Bullmore, E. T. (2000). Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry, 157(1), 1625. doi: 10.1176/AJP.157.1.16/FORMAT/EPUBCrossRefGoogle ScholarPubMed
Yasuda, Y., Okada, N., Nemoto, K., Fukunaga, M., Yamamori, H., Ohi, K., … Hashimoto, R. (2020). Brain morphological and functional features in cognitive subgroups of schizophrenia. Psychiatry and Clinical Neurosciences, 74(3), 191203. doi: 10.1111/pcn.12963CrossRefGoogle ScholarPubMed
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