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Acute dystonic reaction following treatment with a non-classic neuroleptic of the dibenzazepine-type

Published online by Cambridge University Press:  28 April 2020

E. Scholz ,
K. Mann ,
H.W. Schied  and
M. Bartels
E. Scholz*
Affiliation:
Department of Neurology, University of Tübingen
K. Mann
Affiliation:
Department of Psychiatry, University of Tübingen
H.W. Schied
Affiliation:
Department of Psychiatry, University of Tübingen
M. Bartels
Affiliation:
Department of Psychiatry, University of Tübingen
*
Reprint requests to: Demande de tirés à part au : Dr. E. Scholz Department of Neurology, University of Tübingen, Liebermeisterstr. 18-20, D-7400 Tübingen
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Summary

Extrapyramidal side-effects with drug-induced parkinsonism have not previously been reported following treatment with the atypical dibenzazepine-type neuroleptics, clozapine and fluperlapine. We have however observed reversible acute dystonia in a patient following high-dose fluperlapine treatment. The clinical signs of a discrete infantile cerebral palsy observed in our patient are probably one of the risk factors. Although the differential diagnosis of acute dystonia as opposed to tardive dyskinesia was difficult, the patient's symptoms fit more closely the former. Pharmacological aspects of the observed movement disorder are discussed.

Résumé

Résumé

Les effets secondaires de type extra-pyramidal pseudo-parkinsonien occasionnés par la clozapine et la fluperlapine, des neuroleptiques atypiques de type dibenzazépine, n’ont jusqu’à maintenant jamais été rapportes. Pourtant nous avons observé une dystonie réversible chez un patient dont le traitement était constitué de fortes doses de fluperlapine. Les signes d’une discrète parésie cérébrale de l’enfance, observés chez notre patient, constituent probablement l'un des facteurs de risque. Bien que le diagnostic différentiel entre la dystonie aiguë et la dyskinésie tardive ait été difficile à établir, les symptômes du patient correspondaient davantage à la première de ces hypothèses. Les implications pharmacologiques du trouble moteur que nous avons observé sont discutés.

Keywords

Acute dystoniaAtypical neurolepticsFluperlapineDystonie aiguëNeuroleptiques atypiquesFluperlapine
Type
Articles Courts/Short Communications
Information
Psychiatry and Psychobiology , Volume 2 , Issue 5 , 1987 , pp. 350 - 353
Copyright
Copyright © European Psychiatric Association 1987

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