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Scientific Evidence: Creating and Evaluating Experimental Instruments and Research Techniques

Published online by Cambridge University Press:  31 January 2023

William Bechtel
William Bechtel*
Affiliation:
Georgia State University
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Extract

The question of how scientific hypotheses and theories should be evaluated in light of evidence has been a central question in philosophy of science. Far less attention has been given to the questions of how evidence is developed and is itself evaluated. From this neglect, one might assume that the processes by which scientists develop and evaluate evidence are unproblematic. An examination of the actual practice of experimental scientists, however, reveals that they are far from unproblematic. Much of the evidence used to assess scientific theories is gathered with elaborate instruments. At a given time many instruments used in a particular science are noncontroversial. The techniques for using them are agreed upon so that, in a fairly routine way, scientists are able to generate evidence to settle empirical or theoretical disputes. To capture the fact that such instruments and techniques are not questioned, Latour (1987) refers to them as black boxes.

Type
Part X. Experiment
Information
PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association , Volume 1990 , Issue 1: Volume One: Contributed Papers 1990 , 1990 , pp. 558 - 572
Copyright
Copyright © Philosophy of Science Association 1990

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Footnotes

1

I gratefully acknowledge the support of a fellowship in the history of cell biology from the American Society for Cell Biology and research grant DIR 89-12106 from the National Science Foundation.

References

Anderson, N.G. ed. (1966), “The Development of Zonal Centrifuges and Ancillary Systems for Tissue Fractionation and Analysis.” National Cancer Institute Monographs 21.Google Scholar
Baker, R. (1951), “Cytological Techniques. C. Microscopy.” In Cytology and Cell Physiology, Bourne, G. (ed.), Oxford: Oxford University Press, pp. 39–81.Google Scholar
Bechtel, W. (1988), Philosophy of Science: An Overview for Cognitive Science. Hillsdale, NJ: Lawrence Erlbaum Associates.Google Scholar
Bechtel, W. (1989), “An Evolutionary Perspective on the Re-emergence of Cell Biology,” in Issues in Evolutionary Epistemology, Halweg, K. and Hooker, C. A. (eds.). Albany, NY: SUNY Press, pp. 433–57.Google Scholar
Bechtel, W. and Abrahamsen, A.A. (1990), Connectionism and the Mind. An Introduction to Parallel Processing in Networks. Oxford: Basil Blackwell.Google Scholar
Bensley, R.R. and Hoerr, N. (1934), “Studies on Cell Structure by the Freeze-Drying Method. VI. The Preparation and Properties of Mitochondria.” Anatomical Record, pp. 449–55.CrossRefGoogle Scholar
Bensley, R.R. (1951), “Facts Versus Artifacts in Cytology: The Golgi Apparatus.” Experimental Cell Research 2: 1–10.CrossRefGoogle Scholar
Bensley, R.R. (1953), “Introduction and Greetings: Symposium on the Structure and Biochemistry of Mitochondria.” Journal of Histochemistry and Cytochemistry 1: 179–82.Google Scholar
Claude, A. (1940), “Particulate Components of Normal and Tumor Cells.” Science 91: 77-8.CrossRefGoogle ScholarPubMed
Claude, A. (1943), “Distribution of Nucleic Acids in the Cell and the Morphological Constitution of Cytoplasm.” in Biological Symposium. Volume X. Frontiers of Cytochemistry, Cattell, Jacques (ed.). Lancaster, PA: Jacques Cattell Press, pp. 111–29.Google Scholar
Claude, A. (1945), “An Electron Microscope Study of Isolated Mitochondria. Method and Preliminary Results.” Journal of Experimental Medicine 81: 51–60.CrossRefGoogle ScholarPubMed
Claude, A. (1946), “Fractionation of Mammalian Liver Cells by Differential Centrifugation. I. Problems, Methods, and Preparation of Extract.” Journal of Experimental Medicine 84: 51-9.CrossRefGoogle ScholarPubMed
Dalton, A.J. (1953), “Electron microscopy of tissue sections.” International Review of Cytology 2: 403-17.CrossRefGoogle Scholar
de Duve, C. (1971), “Tissue Fraction: Past and Present.” Journal of Cell Biology 50: 20d–55d.CrossRefGoogle ScholarPubMed
de Duve, C. (1963-1964), “The Separation and Characterization of Subcellular Particles.” The Harvey Lectures 59: 49–87.Google Scholar
de Duve, C., Pressman, B.C., Gianetto, R., Wattiaux, R. and Appelmans, F. (1955). “Tissue Fractionation Studies. 6. Intracellular Distribution Pattern of Enzymes in Rat Liver Tissue.” Biochemical Journal 60: 604-17.CrossRefGoogle ScholarPubMed
Fullam, E.F. and Gessler, A.E. (1946), “A High Speed Microtome for the Electron Microscope.” Review of Scientific Instruments 17: 23-5.CrossRefGoogle ScholarPubMed
Hacking, I. (1983), Representing and Intervening. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Haguenau, F. (1958), “The Ergastoplasm: Its History, Ultrastructure, and Biochemistry.” International Review of Cytology 7: 425-83.CrossRefGoogle Scholar
Hanson, N.R. (1957), Patterns of Discovery. Cambridge: Cambridge University Press.Google Scholar
Hogeboom, G.H., Claude, A. and Hotchkiss, R. (1946), “The Distribution of Cytochrome Oxidase and Succinoxidase in the Cytoplasm of the Mammalian Liver Cell.” Journal of Biological Chemistry 165: 615-29.CrossRefGoogle ScholarPubMed
Hogeboom, G.H., Schneider, W.C., and Palade, G.E. (1948), “Cytochemical Studies of Mammalian Tissues. I. Isolation of Intact Mitochondria from Rat Liver: Some Biochemical Properties of Mitochondria and Submicroscopic Particulate Material.” Journal of Biological Chemistry 165: 619-35.CrossRefGoogle Scholar
Latour, B. (1987), Science in Action. How to Follow Scientists and Engineers Through Society. Cambridge, Mass.: Harvard University Press.Google Scholar
Lazarow, A. (1943), “The Chemical Structure of Cytoplasm as Investigated in Professor Bensley’s Laboratory During the Past Ten Years.” in Biological Symposium. Volume X. Frontiers of Cytochemistry, Cattell, Jacques (ed.). Lancaster, PA: Jacques Cattell Press, pp. 111–29.Google Scholar
Marton, L (1968), Early History of the Electron Microscope. San Francisco: San Francisco Press.Google Scholar
Palade, G.E. (1952), “A Study of Fixation for Electron Microscopy.” Journal of Experimental Medicine 95: 285-97.CrossRefGoogle ScholarPubMed
Palade, G.E. (1953), “An Electron Microscope Study of Mitochondrial Structure.” Journal of Histochemistry and Cytochemistry 1: 188–211CrossRefGoogle ScholarPubMed
Palade, G.E. (1955), “A Small Paniculate Component of Cytoplasm.” Journal of Biochemical and Biophysical Cytology 1: 59–68.CrossRefGoogle Scholar
Palade, G.E. and Claude, A. (1949), “The Nature of the Golgi Apparatus. II. Identification of the Golgi Apparatus with a Complex of Myelin Figures.” Journal of Morphology 85: 71–105.CrossRefGoogle Scholar
Palade, G.E. and Porter, K.R., (1954), “Studies on the Endoplasmic Reticulum. Its Identification in Cells in Situ.” Journal of Experimental Medicine 100: 641-55.CrossRefGoogle ScholarPubMed
Palade, G.E. and Siekevitz, P. (1955), “Liver Microsomes: An Integrated Morphological and Biochemical Study.” Journal of Biophysical and Biochemical Cytology 2: 171–200.CrossRefGoogle Scholar
Palade, G.E. (1987), “Cell Fractionation,” in The American Association of Anatomists, 1888-1987, Pauly, J. E. (ed.). Baltimore, Williams and Wilkins, pp. 111–22.Google Scholar
Porter, K.R. (1956-57), “The Submicroscopic Morphology of Protoplasm.” The Harvey Lectures 51: 175–228.Google Scholar
Porter, K.R. (1987), “Electron Microscopy of Cultured Cells.” In The American Association of Anatomists, 1888-1987, Pauly, J.E. (ed.). Baltimore: Williams and Wilkins, pp. 59–67.Google Scholar
Porter, K. R. and Blum, J. (1953), “A Study in Microtomy for Electron Microscopy.” Anatomic Record 117: 685–710.CrossRefGoogle ScholarPubMed
Porter, K. R., Claude, A. and Fullam, E. (1945), “A Study of Tissue Culture Cells by Electron Microscopy: Methods and Preliminary Observations.” Journal of Experimental Medicine 81: 233–46.CrossRefGoogle ScholarPubMed
Porter, K. R. and Kallman, F.L. (1952), “Significance of Cell Particulates as Seen by Electron Microscopy.” Annals of the New York Academy of Science 54: 882-91.CrossRefGoogle ScholarPubMed
Sanders, F. K. (1951), “Cytological Techniques. B. Special Methods.” in Cytology and Cell Physiology, Bourne, G. (ed.). Oxford: Oxford University Press, pp. 20–38.Google Scholar
Schmitt, F. O. (1944-45), “Ultrastructure and the Problem of Cellular Organization.” The Harvey Lectures 40: 249–268.Google Scholar
Schneider, W. C. (1948), “The Intracellular Distribution of Enzymes, III. The Oxidation of Octanoic Acid by Rat Liver Fractions.” Journal of Biological Chemistry, 176, 259-66.CrossRefGoogle Scholar
Sjöstrand, F. (1953), “Electron Microscopy of Mitochondria and Cytoplasmic Double Membranes.” Nature 171: 30–2.CrossRefGoogle ScholarPubMed
Sjöstrand, F. (1956), “The Ultrastructure of Cells as Revealed by the Electron Microscope.” International Review of Cytology 5: 453–533.Google Scholar
Svedberg, T. and Pedersen, K. O. (1940), The Ultracentrifuge. Oxford: Clarendon Press.Google Scholar
Warburg, O. (1913), “Über sauerstoffatmende Kornchen aus Leberzellen und Über Sauerstoffatmung in Berkfeld-Filtraten wässeriger Leberextrakte.” Pflüger’s Archiv für die gesamte Physiologie des Menschen und der Tiere 154: 599–617.CrossRefGoogle Scholar
Wyckoff, R. W. G. (1959), “Optical Methods in Cytology.” in The Cell: Biochemistry, Physiology, and Morphology, Brachet, J. and Mirsky, A. E. (eds.). New York: Academic Press, volume 1, pp. 1–20.Google Scholar