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Oestrogens in the initiation and promotion of breast cancer

Published online by Cambridge University Press:  05 December 2011

R. D. Bulbrook ,
R. E. Leake  and
W. D. George
R. D. Bulbrook
Affiliation:
Imperial Cancer Research Fund Laboratory, Department of Surgery, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
R. E. Leake
Affiliation:
Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.
W. D. George
Affiliation:
Imperial Cancer Research Fund Laboratory, Department of Surgery, Western Infirmary, Glasgow G11 6NT, Scotland, U.K.
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Synopsis

A wide variety of methods has been used to investigate the role of the oestrogens in the aetiology and clinical course of breast cancer. They include measurements of urinary metabolites and the concentrations of oestrogens in blood, saliva, nipple aspirates, cyst fluids, lymph and breast tissues. The function of the oestrogen-binding proteins has also been examined. There is no clear evidence that an excessive oestrogenic stimulus is a determinant of risk of breast cancer and it may be sensible to question this widely-held belief. Variation in the oestrogenic stimulus within the normal range might be responsible for the observed differences in tumour doubling times and for clonal selection. Case/control studies which do not include some measure of tumour growth rates are not an efficient way of investigating these possibilities. Endogenous androgen concentrations show such a strong correlation with the natural history of the disease that it would seem unwise to investigate the role of the oestrogens without taking the androgens into account. Geographical variation in the incidence of breast cancer is probably not due to racial differences in endocrine function.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 95: Oestrogen and the Human Breast , 1989 , pp. 67 - 76
Copyright
Copyright © Royal Society of Edinburgh 1989

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References

Adami, H. O., Johannson, E. D. B., Vegelius, J. & Victor, A. 1979. Serum concentrations of oestrone, androstenedione, testosterone and sex-hormone-binding-globulin in postmenopausal women. Uppsala Journal of Medical Science 84, 259–274.CrossRefGoogle ScholarPubMed
Beex, L. V. A. M. & Koenders, A. J. M. 1984. Is hormonal responsiveness in breast cancer age dependent? Reviews of Endocrine-Related Cancer 19, 5–10.Google Scholar
Brown, J. B. 1955. A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. Biochemical Journal 60, 185–193.CrossRefGoogle ScholarPubMed
Brown, J. B. 1957. The relationship between urinary oestrogens and oestrogens produced in the body. Journal of Endocrinology 16, 202–212.CrossRefGoogle ScholarPubMed
Brown, J. B. 1963. Oestrogens in the human female. Modern Trends in Human Reproductive Physiology 1, 49–66.Google Scholar
Bruning, P. F., Bonfrer, J. M. G. & Hart, A. A. M. 1985. Non-protein-bound estradiol, sex-hormone-binding globulin and breast cancer risk. British Journal of Cancer 51, 479–484.CrossRefGoogle ScholarPubMed
Bulbrook, R. D., Hayward, J. L., Spicer, C. C. & Thomas, B. S. 1962. A comparison between the urinary steroid excretion of normal women and women with advanced breast cancer. Lancet 2, 1235–1237.CrossRefGoogle ScholarPubMed
Bulbrook, R. D., Hayward, J. L., Spicer, C. C. & Thomas, B. S. 1971. Relation between urinary androgen and corticoid excretion and subsequent breast cancer. Lancet 2, 395–398.CrossRefGoogle ScholarPubMed
Bulbrook, R. D., Swain, M. C., Wang, D. Y., Hayward, J. L., Kumaoka, S., Abe, O. & Utsunomiya, J. 1976. Plasma oestradiol-17β, oestrone and progesterone and their urinary metabolites in normal British and Japanese women. European Journal of Cancer and Clinical Oncology 12, 725–728.Google ScholarPubMed
Bulbrook, R. D., Wang, D. Y., Hayward, J. L., Kwa, H. G. & Cleton, F. 1981. Plasma prolactin levels and age in a female population: relation to breast cancer. International Journal of Cancer 28, 43–45.CrossRefGoogle Scholar
Bulbrook, R. D., Moore, J. W., Thomas, B. S., Wang, D. Y., Kwa, H. G., Allen, D. S. & Hayward, J. L. 1985. Tumour and patient variables as indicators of prognosis. The silent period. In Breast Cancer: Origins, detection, and treatment, eds. Rich, M. A., Hager, J. C. & Taylor-Papadimitriou, J., pp. 258–266. Boston: Martinus Nijhoff Publishing.Google Scholar
Bulbrook, R. D., Hayward, J. L., Wang, D. Y., Thomas, B. S., Clark, G. M. G., Allen, D. S. & Moore, J. W. 1986a. Identification of women at high risk of breast cancer. Breast Cancer Research and Treatment 7 (Suppl), 5–10.Google ScholarPubMed
Bulbrook, R. D., Moore, J. W., Clark, G. M. G., Wang, D. Y., Millis, R. R. & Hayward, J. L. 1986b. Relation between risk of breast cancer and bioavailability of estradiol in blood: prospective study in Guernsey. In Endocrinology of the Breast: Basic and Clinical Aspects, eds. Agnelli, A., Bradlow, H. L. & Dogliotto, L. Annals of the New York Academy of Science 464, 373–388.Google Scholar
Bulbrook, R. D., Moore, J. W., Allen, B. S., Gravelle, I. H., Hayward, J. L. & Wang, D. Y. 1988. Sex-hormone-binding globulin and the natural history of breast cancer. Annals of the New York Academy of Science 538, 248–256.CrossRefGoogle ScholarPubMed
Bulbrook, R. D., & Thomas, B. S. 1988. Hormones are ambiguous risk factors for breast cancer. Acta Pathologica Scandinavica (in press).Google Scholar
Cuzick, J., Wang, D. Y. & Bulbrook, R. D. 1986. The prevention of breast cancer. Lancet 1, 83–86.CrossRefGoogle ScholarPubMed
Dansey, R. D., Hessel, P. A., Browde, S., Lange, M., Derman, D., Nissenbaum, M. & Bezwoda, W. R. 1988. Lack of a significant independent effect of race on survival in breast cancer. Cancer 61, 1908–1912.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
England, P., Skinner, L., Cottrell, K. & Sellwood, R. 1974. Serum oestradiol-17β in women with benign and malignant breast disease. British Journal of Cancer 30, 571–576.CrossRefGoogle ScholarPubMed
Feinleib, M. 1968. Breast cancer and artificial menopause; a cohort study. Journal of the National Cancer Institute 41, 315–329.Google ScholarPubMed
Goodman, M. J., Bulbrook, R. D. & Moore, J. W. 1988. The distribution of estradiol in the sera of normal Caucasian, Chinese, Filipina, Hawaiian and Japanese women living in Hawaii. European Journal of Cancer and Clinical Oncology 24, 1855–1860.CrossRefGoogle ScholarPubMed
Harmsen, H. J. & Porsius, A. J. 1988. Endocrine therapy of breast cancer. European Journal of Cancer and Clinical Oncology 24, 1099–1116.CrossRefGoogle ScholarPubMed
Hayward, J. L., Greenwood, F. C., Glober, G., Stemmerman, G., Bulbrook, R. D., Wang, D. Y. & Kumaoka, S. 1978. Endocrine status in normal British, Japanese and Hawaiian-Japanese women. European Journal of Cancer and Clinical Oncology 14, 1221–1228.Google ScholarPubMed
Hayward, J. L., Rubens, R. D., Sexton, S., Tong, D., Bulbrook, R. D., Kumaoka, S., Abe, O., Takatani, O., Yoshida, M., Miura, S., Murai, H. & Ariyoshi, Y. 1982. The response to endocrine therapy in patients with advanced breast cancer in Great Britain and Japan. European Journal of Cancer and Clinical Oncology 18, 1197–1204.CrossRefGoogle ScholarPubMed
Huseby, R. A. & Thomas, L. B. 1954. Histological and histochemical alterations in the normal breast tissues of patients with advanced breast cancer being treated with oestrogenic hormones. Cancer 7, 54–62.3.0.CO;2-5>CrossRefGoogle Scholar
Johannisson, E., Parker, R. A., Landgren, B.-M. & Diczfalusy, E. 1982. Morphometric analysis of the human endometrium in relation to peripheral hormone levels. Fertility and Sterility 38, 564–571.CrossRefGoogle ScholarPubMed
Jull, J. W., Shucksmith, H. S. & Bonser, G. M. 1963. A study of urinary estrogen excretion in relation to breast cancer. Journal of Clinical Endocrinology and Metabolism 23, 433–444.CrossRefGoogle ScholarPubMed
Langley, M. S., Hammond, G. L., Bardsley, A., Sellwood, R. A. & Anderson, D. C. 1985. Serum steroid binding proteins and the bioavailability of estradiol in relation to breast diseases. Journal of the National Cancer Institute 75, 823–829.CrossRefGoogle ScholarPubMed
LeMarchand, L., Kolonel, L. N. & Nomura, A. M. 1985. Breast cancer survival among Hawaii Japanese and Caucasian women. Ten year rates and survival by place of birth. American Journal of Epidemiology 122, 571–578.CrossRefGoogle ScholarPubMed
Lilienfeld, A. 1956. The relationship of cancer of the female breast to artificial menopause and marital status. Cancer 9, 927–934.3.0.CO;2-3>CrossRefGoogle Scholar
Meyer, F., Brown, J. B., Morrison, A. S. & MacMahon, B. 1986. Endogenous sex hormones, prolactin and breast cancer in premenopausal women. Journal of the National Cancer Institute 77, 613–616.CrossRefGoogle ScholarPubMed
Miller, A. B. & Bulbrook, R. D. 1986. UICC Multidisciplinary Project on Breast Cancer: the epidemiology, aetiology and prevention of breast cancer. International Journal of Cancer 37, 173–177.CrossRefGoogle ScholarPubMed
Moolgavkar, S. H. 1986. Hormones and multistage carcinogenesis. Cancer Surveys 5, 635–648.Google ScholarPubMed
Moore, J. W., Clark, G. M. G., Bulbrook, R. D., Hayward, J. L., Murai, J. T., Hammond, G. L. & Siiteri, P. K. 1982. Serum concentrations of total oestradiol and non-protein-bound oestradiol in patients with breast cancer and controls. International Journal of Cancer 29, 17–21.CrossRefGoogle Scholar
Moore, J. W., Clark, G. M. G., Takatani, O., Wakabayashi, Y., Hayward, J. L. & Bulbrook, R. D. 1983. Distribution of 17β-estradiol in the sera of normal British and Japanese women. Journal of the National Cancer Institute 71, 749–754.Google ScholarPubMed
Moore, J. W., Clark, G. M. G., Hoare, S. A., Millis, R. R., Hayward, J. L., Quinlan, M. K., Wang, D. Y. & Bulbrook, R. D. 1986a. The binding of oestradiol to blood proteins and the aetiology of breast cancer. International Journal of Cancer 38, 625–630.CrossRefGoogle ScholarPubMed
Moore, J. W., Thomas, B. S. & Wang, D. Y. 1986b. Endocrine status and the epidemiology and clinical course of breast cancer. Cancer Surveys 5, 537–559.Google ScholarPubMed
Moore, J. W., Thomas, B. S. & Bulbrook, R. D. 1988. The epidemiology and function of sex-hormone-binding globulin. Oxford Reviews of Reproductive Biology 10, 180–236.Google ScholarPubMed
Ota, D. M., Jones, L. A., Jackson, G. L., Jackson, P. M., Kemp, K. & Bauman, D. 1986. Obesity, non-protein-bound oestradiol levels and distribution of oestradiol in the sera of breast cancer patients. Cancer 57, 558–562.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Petrakis, N. L., Wrensch, M. R., Ernster, V. L., Miike, R., Murai, N. & Siiteri, P. K. 1987. Influence of pregnancy and lactation on serum and breast fluid estrogen levels: implications for breast cancer risk. International Journal of Cancer 40, 587–591.CrossRefGoogle ScholarPubMed
Reed, M. J., Cheng, R. W., Noel, C. T., Dudley, H. A. F. & James, V. H. T. 1983. Plasma levels of estrone, estrone sulphate, and estradiol and the percentage of unbound estradiol in postmenopausal women with and without breast disease. Cancer Research 43, 3940–3943.Google ScholarPubMed
Rose, P. R., Lahti, H., Laakso, K., Kettunen, K. & Wynder, E. L. 1986. Serum and breast duct fluid prolactin and estrogen levels in healthy Finnish and American women and patients with fibrocystic disease. Cancer 57, 1155–1554.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Santen, R. J. 1986. Determinants of tissue oestradiol levels in human breast cancer. Cancer Surveys 5, 597–616.Google ScholarPubMed
Schwartz, A. G., Pashko, L. L., Henderson, E. E., Tannen, R. H., Cleary, M. P., Abou-Ghabria, M. & Swern, D. 1983. Dehydroepiandrosterone: An anti-obesity and anticarcinogenic agent. In Commentaries on Research in Breast Disease 3, eds. Bulbrook, R. D. & Taylor, D. J., pp. 113–130. New York: Alan Liss Inc.Google Scholar
Shore, R. E., Pasternack, B. S., Bulbrook, R. D., Moseson, M., Kwa, H. G., Wang, D. Y., Moore, J. W. & Strax, P. 1983. Endocrine and environmental factors in breast cancer: the case for prospective studies. In Commentaries on Research in Breast Disease 3, eds. Bulbrook, R. D. & Taylor, D. J., pp. 1–31. New York: Alan Liss Inc.Google Scholar
Siiteri, P. K., Hammond, G. L. & Nisker, J. A. 1981. Increased availability of serum estrogens in breast cancer: a new hypothesis. In Hormones and Breast Cancer, eds. Pike, M. C., Siiteri, P. K. & Welsch, C. W., Banbury Report 8. New York: Cold Spring Harbour Laboratory.Google Scholar
Siiteri, P. K., Simberg, N. & Murai, J. 1986. Estrogens and breast cancer. Annals of the New York Academy of Science 464, 100–105.CrossRefGoogle ScholarPubMed
Sulkes, A., Fuks, Z., Gordon, A. & Gross, J. 1984. Sex-hormone binding globulin (SHBG) in breast cancer: a correlation with obesity but not with estrogen receptor status. European Journal of Cancer and Clinical Oncology 20, 19–23.CrossRefGoogle Scholar
Takatani, O., Kosano, H., Okumoto, T., Akamatsu, K., Tamakuma, S. & Hiraide, H. 1987. Distribution of estradiol and percentage of free testosterone in sera of Japanese patients: preoperative breast cancer patients and normal controls. Journal of the National Cancer Institute 79, 1199–1204.Google ScholarPubMed
Thomas, B. S., Bulbrook, R. D., Russell, M. J., Hayward, J. L. & Millis, R. R. 1984. Urinary and 17-hydroxylated corticosteroid metabolites and their relation to recurrence rates in early breast cancer. Breast Cancer Research and Treatment 4, 27–35.CrossRefGoogle ScholarPubMed
Vermeulen, A. 1986. Human mammary cancer as a site of sex steroid metabolism. Cancer Surveys 5, 585–595.Google ScholarPubMed
Wang, D. Y., Fantl, V. E., Hahibollahi, F., Clark, G. M. G., Fentiman, I. S., Hayward, J. L. & Bulbrook, R. D. 1986. Salivary oestradiol and progesterone levels in premenopausal women with breast cancer. European Journal of Cancer and Clinical Oncology 22, 427–433.CrossRefGoogle ScholarPubMed
Young, J. S., Bulbrook, R. D. & Greenwood, F. C. 1957. The correlation between urinary oestrogens and vaginal cytology. Lancet 1, 350–353.CrossRefGoogle Scholar
Zumoff, B., Levlin, J., Strain, G. W., Rosenfeld, R. S., O'Connor, J., Freed, S. Z., Kream, J., Whitmore, W. S., Fukushima, D. K. & Hellman, L. 1982. Abnormal levels of plasma hormones in men with prostatic cancer: evidence for a “two-disease” theory. The Prostate 3, 579–588.CrossRefGoogle ScholarPubMed